ARAF

Summary: This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2012].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameA-Raf proto-oncogene, serine/threonine kinase
OMIM IDMIM:311010
Ensembl IDEnsembl:ENSG00000078061
HGNC IDHGNC:HGNC:646
PHARMGKB IDPA24928
Map LocationXp11.3

GO terms in ARAF


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IBA GO:0000165 MAPK cascade
BP TAS GO:0000165 MAPK cascade
BP IEA GO:0000186 activation of MAPKK activity
BP TAS GO:0006464 cellular protein modification process
BP IMP GO:0032006 regulation of TOR signaling
BP IMP GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process
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Gene expression in normal tissue: ARAF

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined35ERK MAPK signaling4Apoptosis regulation2DNA replication1PI3K/MTOR signaling1Mitosis1Protein stability and degradation1Purine metabolism1VEGF signaling pathway1Ferroptosis1

Pathways in ARAF


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Database
Pathway ID
Pathway Des.
wikipathways WP185 Integrin-mediated Cell Adhesion
wikipathways WP2261 Signaling Pathways in Glioblastoma
wikipathways WP2636 Common Pathways Underlying Drug Addiction
wikipathways WP3931 ESC Pluripotency Pathways
wikipathways WP4155 Endometrial cancer
wikipathways WP4205 MET in type 1 papillary renal cell carcinoma
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD425 ERASTIN 2
iGMDRD579 PF750 2
iGMDRD126 Tipifarnib 5
iGMDRD554 CHEMBL1434137 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ARAF

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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