ARAF
Summary: This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| A-Raf proto-oncogene, serine/threonine kinase | MIM:311010 | Ensembl:ENSG00000078061 | HGNC:HGNC:646 | PA24928 | Xp11.3 |
GO terms in ARAF
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0000165 | MAPK cascade |
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | IEA | GO:0000186 | activation of MAPKK activity |
| BP | TAS | GO:0006464 | cellular protein modification process |
| BP | IMP | GO:0032006 | regulation of TOR signaling |
| BP | IMP | GO:0032434 | regulation of proteasomal ubiquitin-dependent protein catabolic process |
| BP | IDA | GO:0033138 | positive regulation of peptidyl-serine phosphorylation |
| BP | IDA | GO:0043066 | negative regulation of apoptotic process |
| CC | ND | GO:0005575 | cellular_component |
| CC | IBA | GO:0005739 | mitochondrion |
| CC | IBA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| MF | TAS | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: ARAF
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ARAF
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP185 | Integrin-mediated Cell Adhesion |
| wikipathways | WP2261 | Signaling Pathways in Glioblastoma |
| wikipathways | WP2636 | Common Pathways Underlying Drug Addiction |
| wikipathways | WP3931 | ESC Pluripotency Pathways |
| wikipathways | WP4155 | Endometrial cancer |
| wikipathways | WP4205 | MET in type 1 papillary renal cell carcinoma |
| wikipathways | WP4216 | Chromosomal and microsatellite instability in colorectal cancer |
| wikipathways | WP422 | MAPK Cascade |
| wikipathways | WP673 | ErbB Signaling Pathway |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04012 | ErbB signaling pathway - Homo sapiens (human) |
| kegg | hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| kegg | hsa04270 | Vascular smooth muscle contraction - Homo sapiens (human) |
| kegg | hsa04650 | Natural killer cell mediated cytotoxicity - Homo sapiens (human) |
| kegg | hsa04720 | Long-term potentiation - Homo sapiens (human) |
| kegg | hsa04726 | Serotonergic synapse - Homo sapiens (human) |
| kegg | hsa04730 | Long-term depression - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| kegg | hsa04910 | Insulin signaling pathway - Homo sapiens (human) |
| kegg | hsa04914 | Progesterone-mediated oocyte maturation - Homo sapiens (human) |
| kegg | hsa05034 | Alcoholism - Homo sapiens (human) |
| kegg | hsa05160 | Hepatitis C - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| kegg | hsa05210 | Colorectal cancer - Homo sapiens (human) |
| kegg | hsa05211 | Renal cell carcinoma - Homo sapiens (human) |
| kegg | hsa05212 | Pancreatic cancer - Homo sapiens (human) |
| kegg | hsa05213 | Endometrial cancer - Homo sapiens (human) |
| kegg | hsa05214 | Glioma - Homo sapiens (human) |
| kegg | hsa05215 | Prostate cancer - Homo sapiens (human) |
| kegg | hsa05218 | Melanoma - Homo sapiens (human) |
| kegg | hsa05219 | Bladder cancer - Homo sapiens (human) |
| kegg | hsa05220 | Chronic myeloid leukemia - Homo sapiens (human) |
| kegg | hsa05221 | Acute myeloid leukemia - Homo sapiens (human) |
| kegg | hsa05223 | Non-small cell lung cancer - Homo sapiens (human) |
| kegg | hsa05224 | Breast cancer - Homo sapiens (human) |
| kegg | hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| kegg | hsa05226 | Gastric cancer - Homo sapiens (human) |
| pharmgkb | PA165980050 | Vemurafenib Pathway, Pharmacodynamics |
| pharmgkb | PA165980050 | update your name in edit mode |
| netpath | Pathway_EGFR1 | EGFR1 |
| biocarta | mapkpathway | mapkinase signaling pathway |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5673000 | RAF activation |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5674135 | MAP2K and MAPK activation |
| reactome | R-HSA-5675221 | Negative regulation of MAPK pathway |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants |
| reactome | R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants |
| reactome | R-HSA-6802949 | Signaling by RAS mutants |
| reactome | R-HSA-6802952 | Signaling by BRAF and RAF fusions |
| reactome | R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF |
| reactome | R-HSA-6802957 | Oncogenic MAPK signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD425 | ERASTIN | 2 |
| iGMDRD579 | PF750 | 2 |
| iGMDRD126 | Tipifarnib | 5 |
| iGMDRD554 | CHEMBL1434137 | 3 |
| iGMDRD781 | Sirolimus | 6 |
| iGMDRD2 | PK-11195 | 2 |
| iGMDRD358 | Semagacestat | 1 |
| iGMDRD634 | SCHEMBL2608041 | 5 |
| iGMDRD470 | Trametinib | 1 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD255 | SB225002 | 1 |
| iGMDRD134 | Sorafenib | 8 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD885 | Compound 110 | 2 |
| iGMDRD226 | ML006 | 2 |
| iGMDRD870 | BRD63610 | 1 |
| iGMDRD187 | BRD9876 | 2 |
| iGMDRD888 | Compound 44 | 2 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD898 | EGFR mAb inhibitor | 1 |
| iGMDRD404 | PD318088 | 1 |
| iGMDRD84 | Lovastatin acid | 1 |
| iGMDRD79 | Gemcitabine | 2 |
| iGMDRD701 | NVP-AUY922 | 1 |
| iGMDRD424 | Tamatinib | 2 |
| iGMDRD57 | Chloropentafluorobenzene | 3 |
| iGMDRD154 | NSC23766 | 2 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 1 |
| iGMDRD873 | BRD8899 | 1 |
| iGMDRD336 | MEK Inhibitor/anti-EGFR mAb | 1 |
| iGMDRD177 | Teniposide | 2 |
| iGMDRD271 | Brefeldin A | 2 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD158 | NSC141540 | 1 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD333 | MEK Inhibitor | 1 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD366 | PI-103 | 4 |
| iGMDRD367 | Ro 28-1675 | 5 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD839 | BRAF inhibitor | 2 |
| iGMDRD882 | CIL41 | 2 |
| iGMDRD82 | Quiflapon | 2 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD147 | Prima-1 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ARAF
CLASSFICATION
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