Summary: The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008].

mitogen-activated protein kinase kinase 1MIM:176872Ensembl:ENSG00000169032HGNC:HGNC:6840PA3058415q22.31

GO terms in MAP2K1

Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0000165MAPK cascade
BPIBAGO:0000187activation of MAPK activity
BPIDAGO:0000187activation of MAPK activity
BPTASGO:0000187activation of MAPK activity
BPIDAGO:0006468protein phosphorylation
BPIMPGO:0007050cell cycle arrest
BPTASGO:0007165signal transduction
BPIBAGO:0007346regulation of mitotic cell cycle
BPIEAGO:0007507heart development
BPIDAGO:0008285negative regulation of cell proliferation
BPIMPGO:0010628positive regulation of gene expression
BPIGIGO:0010629negative regulation of gene expression
BPIMPGO:0018107peptidyl-threonine phosphorylation
BPIEAGO:0018108peptidyl-tyrosine phosphorylation
BPIEAGO:0021697cerebellar cortex formation
BPIBAGO:0023014signal transduction by protein phosphorylation
BPIBAGO:0030182neuron differentiation
BPIEAGO:0030182neuron differentiation
BPIEAGO:0030216keratinocyte differentiation
BPIEAGO:0030878thyroid gland development
BPIBAGO:0032147activation of protein kinase activity
BPTASGO:0032872regulation of stress-activated MAPK cascade
BPIMPGO:0045893positive regulation of transcription, DNA-templated
BPIEAGO:0048538thymus development
BPIEAGO:0048679regulation of axon regeneration
BPIEAGO:0048870cell motility
BPIEAGO:0050772positive regulation of axonogenesis
BPIEAGO:0060020Bergmann glial cell differentiation
BPIEAGO:0060324face development
BPIEAGO:0060440trachea formation
BPIEAGO:0060502epithelial cell proliferation involved in lung morphogenesis
BPIEAGO:0060674placenta blood vessel development
BPIEAGO:0060711labyrinthine layer development
BPIMPGO:0070371ERK1 and ERK2 cascade
BPIMPGO:0070374positive regulation of ERK1 and ERK2 cascade
BPIDAGO:0071902positive regulation of protein serine/threonine kinase activity
BPTASGO:0090170regulation of Golgi inheritance
BPIMPGO:0090398cellular senescence
BPIMPGO:1903800positive regulation of production of miRNAs involved in gene silencing by miRNA
BPTASGO:2000641regulation of early endosome to late endosome transport
CCTASGO:0005769early endosome
CCTASGO:0005770late endosome
CCIDAGO:0005783endoplasmic reticulum
CCTASGO:0005794Golgi apparatus
CCIEAGO:0005815microtubule organizing center
CCIDAGO:0005886plasma membrane
CCTASGO:0005925focal adhesion
MFIDAGO:0004672protein kinase activity
MFIBAGO:0004674protein serine/threonine kinase activity
MFIMPGO:0004674protein serine/threonine kinase activity
MFTASGO:0004674protein serine/threonine kinase activity
MFIBAGO:0004708MAP kinase kinase activity
MFIDAGO:0004708MAP kinase kinase activity
MFTASGO:0004712protein serine/threonine/tyrosine kinase activity
MFIEAGO:0004713protein tyrosine kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIDAGO:0008022protein C-terminus binding
MFIDAGO:0043539protein serine/threonine kinase activator activity
MFIDAGO:0047485protein N-terminus binding
MFIPIGO:0097110scaffold protein binding

Gene expression in normal tissue: MAP2K1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MAP2K1

DatabasePathway IDPathway Des.
humancycPWY66-14MAP kinase cascade
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04012ErbB signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04022cGMP-PKG signaling pathway - Homo sapiens (human)
kegghsa04024cAMP signaling pathway - Homo sapiens (human)
kegghsa04062Chemokine signaling pathway - Homo sapiens (human)
kegghsa04066HIF-1 signaling pathway - Homo sapiens (human)
kegghsa04068FoxO signaling pathway - Homo sapiens (human)
kegghsa04071Sphingolipid signaling pathway - Homo sapiens (human)
kegghsa04072Phospholipase D signaling pathway - Homo sapiens (human)
kegghsa04114Oocyte meiosis - Homo sapiens (human)
kegghsa04140Autophagy - animal - Homo sapiens (human)
kegghsa04150mTOR signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04210Apoptosis - Homo sapiens (human)
kegghsa04218Cellular senescence - Homo sapiens (human)
kegghsa04270Vascular smooth muscle contraction - Homo sapiens (human)
kegghsa04370VEGF signaling pathway - Homo sapiens (human)
kegghsa04371Apelin signaling pathway - Homo sapiens (human)
kegghsa04380Osteoclast differentiation - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa04540Gap junction - Homo sapiens (human)
kegghsa04550Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
kegghsa04620Toll-like receptor signaling pathway - Homo sapiens (human)
kegghsa04650Natural killer cell mediated cytotoxicity - Homo sapiens (human)
kegghsa04660T cell receptor signaling pathway - Homo sapiens (human)
kegghsa04662B cell receptor signaling pathway - Homo sapiens (human)
kegghsa04664Fc epsilon RI signaling pathway - Homo sapiens (human)
kegghsa04666Fc gamma R-mediated phagocytosis - Homo sapiens (human)
kegghsa04668TNF signaling pathway - Homo sapiens (human)
kegghsa04720Long-term potentiation - Homo sapiens (human)
kegghsa04722Neurotrophin signaling pathway - Homo sapiens (human)
kegghsa04725Cholinergic synapse - Homo sapiens (human)
kegghsa04726Serotonergic synapse - Homo sapiens (human)
kegghsa04730Long-term depression - Homo sapiens (human)
kegghsa04810Regulation of actin cytoskeleton - Homo sapiens (human)
kegghsa04910Insulin signaling pathway - Homo sapiens (human)
kegghsa04912GnRH signaling pathway - Homo sapiens (human)
kegghsa04914Progesterone-mediated oocyte maturation - Homo sapiens (human)
kegghsa04915Estrogen signaling pathway - Homo sapiens (human)
kegghsa04916Melanogenesis - Homo sapiens (human)
kegghsa04917Prolactin signaling pathway - Homo sapiens (human)
kegghsa04919Thyroid hormone signaling pathway - Homo sapiens (human)
kegghsa04921Oxytocin signaling pathway - Homo sapiens (human)
kegghsa04926Relaxin signaling pathway - Homo sapiens (human)
kegghsa04934Cushing,s syndrome - Homo sapiens (human)
kegghsa05020Prion diseases - Homo sapiens (human)
kegghsa05034Alcoholism - Homo sapiens (human)
kegghsa05161Hepatitis B - Homo sapiens (human)
kegghsa05164Influenza A - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05205Proteoglycans in cancer - Homo sapiens (human)
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)
kegghsa05210Colorectal cancer - Homo sapiens (human)
kegghsa05211Renal cell carcinoma - Homo sapiens (human)
kegghsa05212Pancreatic cancer - Homo sapiens (human)
kegghsa05213Endometrial cancer - Homo sapiens (human)
kegghsa05214Glioma - Homo sapiens (human)
kegghsa05215Prostate cancer - Homo sapiens (human)
kegghsa05216Thyroid cancer - Homo sapiens (human)
kegghsa05218Melanoma - Homo sapiens (human)
kegghsa05219Bladder cancer - Homo sapiens (human)
kegghsa05220Chronic myeloid leukemia - Homo sapiens (human)
kegghsa05221Acute myeloid leukemia - Homo sapiens (human)
kegghsa05223Non-small cell lung cancer - Homo sapiens (human)
kegghsa05224Breast cancer - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
kegghsa05226Gastric cancer - Homo sapiens (human)
kegghsa05230Central carbon metabolism in cancer - Homo sapiens (human)
kegghsa05231Choline metabolism in cancer - Homo sapiens (human)
netpathPathway_Fibroblast__growth__factor-1Fibroblast growth factor-1
biocartaanthraxpathwayanthrax toxin mechanism of action
biocartaat1rpathwayangiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling
biocartabarrestinsrcpathwayroles of arrestin dependent recruitment of src kinases in gpcr signaling
biocartabarrmapkpathwayrole of -arrestins in the activation and targeting of map kinases
biocartabcrpathwaybcr signaling pathway
biocartacardiacegfpathwayrole of egf receptor transactivation by gpcrs in cardiac hypertrophy
biocartaccr3pathwayccr3 signaling in eosinophils
biocartacdk5pathwayphosphorylation of mek1 by cdk5/p35 down regulates the map kinase pathway
biocartacdmacpathwaycadmium induces dna synthesis and proliferation in macrophages
biocartaceramidepathwayceramide signaling pathway
biocartaecmpathwayerk and pi-3 kinase are necessary for collagen binding in corneal epithelia
biocartaedg1pathwayphospholipids as signalling intermediaries
biocartaegfpathwayegf signaling pathway
biocartaerk5pathwayrole of erk5 in neuronal survival pathway
biocartaerkpathwayerk1/erk2 mapk signaling pathway
biocartafcer1pathwayfc epsilon receptor i signaling in mast cells
biocartafmlppathwayfmlp induced chemokine gene expression in hmc-1 cells
biocartagleevecpathwayinhibition of cellular proliferation by gleevec
biocartagpcrpathwaysignaling pathway from g-protein families
biocartahbxpathwaycalcium signaling by hbx of hepatitis b virus
biocartahcmvpathwayhuman cytomegalovirus and map kinase pathways
biocartaher2pathwayrole of erbb2 in signal transduction and oncology
biocartaigf1pathwayigf-1 signaling pathway
biocartail2rbpathwayil-2 receptor beta chain in t cell activation
biocartakeratinocytepathwaykeratinocyte differentiation
biocartamalpathwayrole of mal in rho-mediated activation of srf
biocartamapkpathwaymapkinase signaling pathway
biocartamcalpainpathwaymcalpain and friends in cell motility
biocartamelanocytepathwaymelanocyte development and pigmentation pathway
biocartangfpathwaynerve growth factor pathway (ngf)
biocartankcellspathwayras-independent pathway in nk cell-mediated cytotoxicity
biocartapdgfpathwaypdgf signaling pathway
biocartapyk2pathwaylinks between pyk2 and map kinases
biocartaraccycdpathwayinfluence of ras and rho proteins on g1 to s transition
biocartasam68pathwayregulation of splicing through sam68
biocartasmrtepathwaymap kinase inactivation of smrt corepressor
biocartasppapathwayaspirin blocks signaling pathway involved in platelet activation
biocartasprypathwaysprouty regulation of tyrosine kinase signals
biocartatcrpathwayt cell receptor signaling pathway
biocartatffpathwaytrefoil factors initiate mucosal healing
biocartatgfbpathwaytgf beta signaling pathway
biocartatpopathwaytpo signaling pathway
reactomeR-HSA-110056MAPK3 (ERK1) activation
reactomeR-HSA-112409RAF-independent MAPK1/3 activation
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-166016Toll Like Receptor 4 (TLR4) Cascade
reactomeR-HSA-166058MyD88:Mal cascade initiated on plasma membrane
reactomeR-HSA-166166MyD88-independent TLR4 cascade
reactomeR-HSA-168138Toll Like Receptor 9 (TLR9) Cascade
reactomeR-HSA-168142Toll Like Receptor 10 (TLR10) Cascade
reactomeR-HSA-168164Toll Like Receptor 3 (TLR3) Cascade
reactomeR-HSA-168176Toll Like Receptor 5 (TLR5) Cascade
reactomeR-HSA-168179Toll Like Receptor TLR1:TLR2 Cascade
reactomeR-HSA-168181Toll Like Receptor 7/8 (TLR7/8) Cascade
reactomeR-HSA-168188Toll Like Receptor TLR6:TLR2 Cascade
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168898Toll-Like Receptors Cascades
reactomeR-HSA-181438Toll Like Receptor 2 (TLR2) Cascade
reactomeR-HSA-373760L1CAM interactions
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-445144Signal transduction by L1
reactomeR-HSA-446652Interleukin-1 family signaling
reactomeR-HSA-448424Interleukin-17 signaling
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-450294MAP kinase activation
reactomeR-HSA-5210891Uptake and function of anthrax toxins
reactomeR-HSA-5339562Uptake and actions of bacterial toxins
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5663205Infectious disease
reactomeR-HSA-5673000RAF activation
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5674135MAP2K and MAPK activation
reactomeR-HSA-5674499Negative feedback regulation of MAPK pathway
reactomeR-HSA-5675221Negative regulation of MAPK pathway
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684264MAP3K8 (TPL2)-dependent MAPK1/3 activation
reactomeR-HSA-5684996MAPK1/MAPK3 signaling
reactomeR-HSA-6802946Signaling by moderate kinase activity BRAF mutants
reactomeR-HSA-6802948Signaling by high-kinase activity BRAF mutants
reactomeR-HSA-6802949Signaling by RAS mutants
reactomeR-HSA-6802952Signaling by BRAF and RAF fusions
reactomeR-HSA-6802955Paradoxical activation of RAF signaling by kinase inactive BRAF
reactomeR-HSA-6802957Oncogenic MAPK signaling
reactomeR-HSA-9020702Interleukin-1 signaling
reactomeR-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling
reactomeR-HSA-975138TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
reactomeR-HSA-975155MyD88 dependent cascade initiated on endosome
reactomeR-HSA-975871MyD88 cascade initiated on plasma membrane
smpdbSMP00358Fc Epsilon Receptor I Signaling in Mast Cells
smpdbSMP00391Insulin Signalling
wikipathwaysWP127IL-5 Signaling Pathway
wikipathwaysWP1434Osteopontin Signaling
wikipathwaysWP1449Regulation of toll-like receptor signaling pathway
wikipathwaysWP1544MicroRNAs in cardiomyocyte hypertrophy
wikipathwaysWP185Integrin-mediated Cell Adhesion
wikipathwaysWP195IL-1 signaling pathway
wikipathwaysWP1993Angiogenesis overview
wikipathwaysWP2018RANKL-RANK (Receptor activator of NFKB (ligand)) Signaling Pathway
wikipathwaysWP2032Human Thyroid Stimulating Hormone (TSH) signaling pathway
wikipathwaysWP2034Leptin signaling pathway
wikipathwaysWP2037Prolactin Signaling Pathway
wikipathwaysWP205IL-7 Signaling Pathway
wikipathwaysWP2197Endothelin Pathways
wikipathwaysWP22IL-9 Signaling Pathway
wikipathwaysWP2203Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway
wikipathwaysWP2261Signaling Pathways in Glioblastoma
wikipathwaysWP2263Androgen Receptor Network in Prostate Cancer
wikipathwaysWP23B Cell Receptor Signaling Pathway
wikipathwaysWP2324AGE-RAGE pathway
wikipathwaysWP2332Interleukin-11 Signaling Pathway
wikipathwaysWP2355Corticotropin-releasing hormone signaling pathway
wikipathwaysWP2374Oncostatin M Signaling Pathway
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathwaysWP2586Aryl Hydrocarbon Receptor
wikipathwaysWP259Nifedipine Activity
wikipathwaysWP2636Common Pathways Underlying Drug Addiction
wikipathwaysWP2637Structural Pathway of Interleukin 1 (IL-1)
wikipathwaysWP2795Cardiac Hypertrophic Response
wikipathwaysWP2828Bladder Cancer
wikipathwaysWP286IL-3 Signaling Pathway
wikipathwaysWP304Kit receptor signaling pathway
wikipathwaysWP306Focal Adhesion
wikipathwaysWP313Signaling of Hepatocyte Growth Factor Receptor
wikipathwaysWP364IL-6 signaling pathway
wikipathwaysWP366TGF-beta Signaling Pathway
wikipathwaysWP3676BDNF-TrkB Signaling
wikipathwaysWP3680Association Between Physico-Chemical Features and Toxicity Associated Pathways
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3863T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection
wikipathwaysWP38794-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP3915Angiopoietin Like Protein 8 Regulatory Pathway
wikipathwaysWP3929Chemokine signaling pathway
wikipathwaysWP3931ESC Pluripotency Pathways
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP3972PDGFR-beta pathway
wikipathwaysWP3981miRNA regulation of prostate cancer signaling pathways
wikipathwaysWP4155Endometrial cancer
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP4205MET in type 1 papillary renal cell carcinoma
wikipathwaysWP4216Chromosomal and microsatellite instability in colorectal cancer
wikipathwaysWP422MAPK Cascade
wikipathwaysWP4223Ras Signaling
wikipathwaysWP4239EMT transition in Colorectal Cancer
wikipathwaysWP437EGF-EGFR Signaling Pathway
wikipathwaysWP481Insulin Signaling
wikipathwaysWP49IL-2 Signaling Pathway
wikipathwaysWP51Regulation of Actin Cytoskeleton
wikipathwaysWP581EPO Receptor Signaling
wikipathwaysWP615Senescence and Autophagy in Cancer
wikipathwaysWP673ErbB Signaling Pathway
wikipathwaysWP69T-Cell antigen Receptor (TCR) Signaling Pathway
wikipathwaysWP712Estrogen signaling pathway
wikipathwaysWP722Serotonin HTR1 Group and FOS Pathway
wikipathwaysWP732Serotonin Receptor 2 and ELK-SRF-GATA4 signaling
wikipathwaysWP734Serotonin Receptor 4-6-7 and NR3C Signaling
wikipathwaysWP75Toll-like Receptor Signaling Pathway
pidanthraxpathwayCellular roles of Anthrax toxin
pidar_nongenomic_pathwayNongenotropic Androgen signaling
pidbcr_5pathwayBCR signaling pathway
pidcd8tcrdownstreampathwayDownstream signaling in naïve CD8+ T cells
pidceramide_pathwayCeramide signaling pathway
pidcxcr3pathwayCXCR3-mediated signaling events
pidephbfwdpathwayEPHB forward signaling
piderbb1_downstream_pathwayErbB1 downstream signaling
piderbb2erbb3pathwayErbB2/ErbB3 signaling events
pidfak_pathwaySignaling events mediated by focal adhesion kinase
pidfcer1pathwayFc-epsilon receptor I signaling in mast cells
pidfoxm1pathwayFOXM1 transcription factor network
pidgmcsf_pathwayGMCSF-mediated signaling events
pidhedgehog_glipathwayHedgehog signaling events mediated by Gli proteins
pidifngpathwayIFN-gamma pathway
pidil2_1pathwayIL2-mediated signaling events
pidkitpathwaySignaling events mediated by Stem cell factor receptor (c-Kit)
pidmapktrkpathwayTrk receptor signaling mediated by the MAPK pathway
pidmet_pathwaySignaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
pidmtor_4pathwaymTOR signaling pathway
pidnetrin_pathwayNetrin-mediated signaling events
pidpdgfrbpathwayPDGFR-beta signaling pathway
pidpi3kcibpathwayClass IB PI3K non-lipid kinase events
pidshp2_pathwaySHP2 signaling
pidtcrraspathwayRas signaling in the CD4+ TCR pathway
pidtrkrpathwayNeurotrophic factor-mediated Trk receptor signaling
pidvegfr1_2_pathwaySignaling events mediated by VEGFR1 and VEGFR2
pharmgkbPA162356267EGFR Inhibitor Pathway, Pharmacodynamics
pharmgkbPA165959584Sorafenib Pharmacodynamics
pharmgkbPA165980050Vemurafenib Pathway, Pharmacodynamics
pharmgkbPA165980050update your name in edit mode
pharmgkbPA2032VEGF Signaling Pathway

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD5Tyrphostin AG 14786
iGMDRD514ERK inhibitor10
iGMDRD962novel MEK inhibitor2
iGMDRD333MEK Inhibitor45
iGMDRD840BRAF inhibitors in BRAF mutant tumor2
iGMDRD839BRAF inhibitor15
iGMDRD898EGFR mAb inhibitor1
iGMDRD523Cyanoquinoline, 113
iGMDRD816anti-EGFR mAbs1
iGMDRD887Compound 23 citrate3
iGMDRD61Kinetin riboside6
iGMDRD446LY 21832403

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAP2K1