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MAP2K1

Summary: The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Namemitogen-activated protein kinase kinase 1 OMIM IDMIM:176872 Ensembl IDEnsembl:ENSG00000169032 HGNC IDHGNC:HGNC:6840 PHARMGKB IDPA30584 Map Location15q22.31

Gene Categories:

DRUGGABLE GENOME TYROSINE KINASE PROTEIN PHOSPHATASE TUMOR SUPPRESSOR SERINE THREONINE KINASE KINASE CLINICALLY ACTIONABLE

GO terms in MAP2K1

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Term Type	Evidence Type	GO Term ID	GO Des.
BP	TAS	GO:0000165	MAPK cascade
BP	IBA	GO:0000187	activation of MAPK activity
BP	IDA	GO:0000187	activation of MAPK activity
BP	TAS	GO:0000187	activation of MAPK activity
BP	IDA	GO:0006468	protein phosphorylation
BP	TAS	GO:0006935	chemotaxis

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Gene expression in normal tissue: MAP2K1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MAP2K1

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Database	Pathway ID	Pathway Des.
humancyc	PWY66-14	MAP kinase cascade
kegg	hsa04010	MAPK signaling pathway - Homo sapiens (human)
kegg	hsa04012	ErbB signaling pathway - Homo sapiens (human)
kegg	hsa04014	Ras signaling pathway - Homo sapiens (human)
kegg	hsa04015	Rap1 signaling pathway - Homo sapiens (human)
kegg	hsa04022	cGMP-PKG signaling pathway - Homo sapiens (human)

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD5	Tyrphostin AG 1478	6
iGMDRD514	ERK inhibitor	10
iGMDRD202	Curcumin	3
iGMDRD962	novel MEK inhibitor	2

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAP2K1

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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