Summary: This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, cognitive disability, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq, Jul 2008].

HRas proto-oncogene, GTPaseMIM:190020Ensembl:ENSG00000174775HGNC:HGNC:5173PA2944411p15.5

GO terms in HRAS

Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0003924GTPase activity
MFIMPGO:0003924GTPase activity
MFIPIGO:0005515protein binding
MFIDAGO:0005525GTP binding
MFIMPGO:0005525GTP binding
MFIPIGO:0008022protein C-terminus binding
MFIMPGO:0019003GDP binding
CCIEAGO:0000139Golgi membrane
CCIDAGO:0005794Golgi apparatus
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIEAGO:0048471perinuclear region of cytoplasm
BPTASGO:0000165MAPK cascade
BPIDAGO:0001934positive regulation of protein phosphorylation
BPTASGO:0002223stimulatory C-type lectin receptor signaling pathway
BPIDAGO:0007050cell cycle arrest
BPIMPGO:0007050cell cycle arrest
BPIDAGO:0007093mitotic cell cycle checkpoint
BPNASGO:0007165signal transduction
BPTASGO:0007166cell surface receptor signaling pathway
BPIDAGO:0007265Ras protein signal transduction
BPTASGO:0007265Ras protein signal transduction
BPIEAGO:0008283cell proliferation
BPIDAGO:0008284positive regulation of cell proliferation
BPIDAGO:0008285negative regulation of cell proliferation
BPTASGO:0009887animal organ morphogenesis
BPIDAGO:0010629negative regulation of gene expression
BPIDAGO:0010863positive regulation of phospholipase C activity
BPIDAGO:0030335positive regulation of cell migration
BPIEAGO:0032729positive regulation of interferon-gamma production
BPIDAGO:0034260negative regulation of GTPase activity
BPIEAGO:0035900response to isolation stress
BPIEAGO:0042088T-helper 1 type immune response
BPIEAGO:0042832defense response to protozoan
BPIDAGO:0043406positive regulation of MAP kinase activity
BPIDAGO:0043410positive regulation of MAPK cascade
BPIEAGO:0043524negative regulation of neuron apoptotic process
BPIDAGO:0043547positive regulation of GTPase activity
BPIEAGO:0045740positive regulation of DNA replication
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0046330positive regulation of JNK cascade
BPIEAGO:0046579positive regulation of Ras protein signal transduction
BPTASGO:0048013ephrin receptor signaling pathway
BPIEAGO:0048169regulation of long-term neuronal synaptic plasticity
BPIMPGO:0050679positive regulation of epithelial cell proliferation
BPIEAGO:0050852T cell receptor signaling pathway
BPIEAGO:0051291protein heterooligomerization
BPIDAGO:0070374positive regulation of ERK1 and ERK2 cascade
BPIDAGO:0071480cellular response to gamma radiation
BPIDAGO:0090303positive regulation of wound healing
BPIMPGO:0090314positive regulation of protein targeting to membrane
BPIDAGO:0090398cellular senescence
BPIEAGO:0097193intrinsic apoptotic signaling pathway
BPIDAGO:1900029positive regulation of ruffle assembly
BPIDAGO:2000251positive regulation of actin cytoskeleton reorganization
BPIDAGO:2000630positive regulation of miRNA metabolic process

Gene expression in normal tissue: HRAS

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in HRAS

DatabasePathway IDPathway Des.
biocartaat1rpathwayangiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling
biocartabarrestinsrcpathwayroles of arrestin dependent recruitment of src kinases in gpcr signaling
biocartabcrpathwaybcr signaling pathway
biocartabiopeptidespathwaybioactive peptide induced signaling pathway
biocartacardiacegfpathwayrole of egf receptor transactivation by gpcrs in cardiac hypertrophy
biocartaccr3pathwayccr3 signaling in eosinophils
biocartacdk5pathwayphosphorylation of mek1 by cdk5/p35 down regulates the map kinase pathway
biocartacdmacpathwaycadmium induces dna synthesis and proliferation in macrophages
biocartacrebpathwaytranscription factor creb and its extracellular signals
biocartacxcr4pathwaycxcr4 signaling pathway
biocartaedg1pathwayphospholipids as signalling intermediaries
biocartaegfpathwayegf signaling pathway
biocartaepopathwayepo signaling pathway
biocartaerk5pathwayrole of erk5 in neuronal survival pathway
biocartaerkpathwayerk1/erk2 mapk signaling pathway
biocartaetspathwaymets affect on macrophage differentiation
biocartafcer1pathwayfc epsilon receptor i signaling in mast cells
biocartafmlppathwayfmlp induced chemokine gene expression in hmc-1 cells
biocartagleevecpathwayinhibition of cellular proliferation by gleevec
biocartagpcrpathwaysignaling pathway from g-protein families
biocartahbxpathwaycalcium signaling by hbx of hepatitis b virus
biocartaher2pathwayrole of erbb2 in signal transduction and oncology
biocartaigf1pathwayigf-1 signaling pathway
biocartaigf1rpathwaymultiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation
biocartail2pathwayil 2 signaling pathway
biocartail2rbpathwayil-2 receptor beta chain in t cell activation
biocartail3pathwayil 3 signaling pathway
biocartail6pathwayil 6 signaling pathway
biocartainsulinpathwayinsulin signaling pathway
biocartaintegrinpathwayintegrin signaling pathway
biocartakeratinocytepathwaykeratinocyte differentiation
biocartalongevitypathwaythe igf-1 receptor and longevity
biocartamalpathwayrole of mal in rho-mediated activation of srf
biocartamapkpathwaymapkinase signaling pathway
biocartamcalpainpathwaymcalpain and friends in cell motility
biocartamelanocytepathwaymelanocyte development and pigmentation pathway
biocartamprpathwayhow progesterone initiates the oocyte maturation
biocartanfatpathwaynfat and hypertrophy of the heart
biocartangfpathwaynerve growth factor pathway (ngf)
biocartap38mapkpathwayp38 mapk signaling pathway
biocartapdgfpathwaypdgf signaling pathway
biocartapyk2pathwaylinks between pyk2 and map kinases
biocartaraccycdpathwayinfluence of ras and rho proteins on g1 to s transition
biocartaraspathwayras signaling pathway
biocartasam68pathwayregulation of splicing through sam68
biocartasmrtepathwaymap kinase inactivation of smrt corepressor
biocartasppapathwayaspirin blocks signaling pathway involved in platelet activation
biocartasprypathwaysprouty regulation of tyrosine kinase signals
biocartatcrpathwayt cell receptor signaling pathway
biocartatffpathwaytrefoil factors initiate mucosal healing
biocartatpopathwaytpo signaling pathway
biocartatrkapathwaytrka receptor signaling pathway
biocartavegfpathwayvegf hypoxia and angiogenesis
reactomeR-HSA-112314Neurotransmitter receptors and postsynaptic signal transmission
reactomeR-HSA-112315Transmission across Chemical Synapses
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-112399IRS-mediated signalling
reactomeR-HSA-112412SOS-mediated signalling
reactomeR-HSA-1168372Downstream signaling events of B Cell Receptor (BCR)
reactomeR-HSA-1169092Activation of RAS in B cells
reactomeR-HSA-1226099Signaling by FGFR in disease
reactomeR-HSA-1227986Signaling by ERBB2
reactomeR-HSA-1227986Signaling by ERBB2
reactomeR-HSA-1236382Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
reactomeR-HSA-1236394Signaling by ERBB4
reactomeR-HSA-1250196SHC1 events in ERBB2 signaling
reactomeR-HSA-1250347SHC1 events in ERBB4 signaling
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-1433557Signaling by SCF-KIT
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643713Signaling by EGFR in Cancer
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-167044Signalling to RAS
reactomeR-HSA-167044Signalling to RAS
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-171007p38MAPK events
reactomeR-HSA-171007p38MAPK events
reactomeR-HSA-177929Signaling by EGFR
reactomeR-HSA-179812GRB2 events in EGFR signaling
reactomeR-HSA-180336SHC1 events in EGFR signaling
reactomeR-HSA-186763Downstream signal transduction
reactomeR-HSA-186797Signaling by PDGF
reactomeR-HSA-187037Signaling by NTRK1 (TRKA)
reactomeR-HSA-187037Signaling by NTRK1 (TRKA)
reactomeR-HSA-187687Signalling to ERKs
reactomeR-HSA-187687Signalling to ERKs
reactomeR-HSA-190236Signaling by FGFR
reactomeR-HSA-194138Signaling by VEGF
reactomeR-HSA-1963640GRB2 events in ERBB2 signaling
reactomeR-HSA-1963640GRB2 events in ERBB2 signaling
reactomeR-HSA-202733Cell surface interactions at the vascular wall
reactomeR-HSA-210993Tie2 Signaling
reactomeR-HSA-2172127DAP12 interactions
reactomeR-HSA-2179392EGFR Transactivation by Gastrin
reactomeR-HSA-2404192Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
reactomeR-HSA-2424491DAP12 signaling
reactomeR-HSA-2428924IGF1R signaling cascade
reactomeR-HSA-2428928IRS-related events triggered by IGF1R
reactomeR-HSA-2428933SHC-related events triggered by IGF1R
reactomeR-HSA-2454202Fc epsilon receptor (FCERI) signaling
reactomeR-HSA-2682334EPH-Ephrin signaling
reactomeR-HSA-2871796FCERI mediated MAPK activation
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-375165NCAM signaling for neurite out-growth
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-3928662EPHB-mediated forward signaling
reactomeR-HSA-416476G alpha (q) signalling events
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-438064Post NMDA receptor activation events
reactomeR-HSA-4420097VEGFA-VEGFR2 Pathway
reactomeR-HSA-442742CREB phosphorylation through the activation of Ras
reactomeR-HSA-442755Activation of NMDA receptor and postsynaptic events
reactomeR-HSA-442982Ras activation upon Ca2+ influx through NMDA receptor
reactomeR-HSA-5218921VEGFR2 mediated cell proliferation
reactomeR-HSA-5621481C-type lectin receptors (CLRs)
reactomeR-HSA-5621575CD209 (DC-SIGN) signaling
reactomeR-HSA-5637810Constitutive Signaling by EGFRvIII
reactomeR-HSA-5637812Signaling by EGFRvIII in Cancer
reactomeR-HSA-5637815Signaling by Ligand-Responsive EGFR Variants in Cancer
reactomeR-HSA-5654687Downstream signaling of activated FGFR1
reactomeR-HSA-5654688SHC-mediated cascade:FGFR1
reactomeR-HSA-5654693FRS-mediated FGFR1 signaling
reactomeR-HSA-5654696Downstream signaling of activated FGFR2
reactomeR-HSA-5654699SHC-mediated cascade:FGFR2
reactomeR-HSA-5654700FRS-mediated FGFR2 signaling
reactomeR-HSA-5654704SHC-mediated cascade:FGFR3
reactomeR-HSA-5654706FRS-mediated FGFR3 signaling
reactomeR-HSA-5654708Downstream signaling of activated FGFR3
reactomeR-HSA-5654712FRS-mediated FGFR4 signaling
reactomeR-HSA-5654716Downstream signaling of activated FGFR4
reactomeR-HSA-5654719SHC-mediated cascade:FGFR4
reactomeR-HSA-5654736Signaling by FGFR1
reactomeR-HSA-5654738Signaling by FGFR2
reactomeR-HSA-5654741Signaling by FGFR3
reactomeR-HSA-5654743Signaling by FGFR4
reactomeR-HSA-5655253Signaling by FGFR2 in disease
reactomeR-HSA-5655291Signaling by FGFR4 in disease
reactomeR-HSA-5655302Signaling by FGFR1 in disease
reactomeR-HSA-5655332Signaling by FGFR3 in disease
reactomeR-HSA-5658442Regulation of RAS by GAPs
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5673000RAF activation
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5674135MAP2K and MAPK activation
reactomeR-HSA-5675221Negative regulation of MAPK pathway
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684996MAPK1/MAPK3 signaling
reactomeR-HSA-6802946Signaling by moderate kinase activity BRAF mutants
reactomeR-HSA-6802948Signaling by high-kinase activity BRAF mutants
reactomeR-HSA-6802949Signaling by RAS mutants
reactomeR-HSA-6802952Signaling by BRAF and RAF fusions
reactomeR-HSA-6802953RAS signaling downstream of NF1 loss-of-function variants
reactomeR-HSA-6802955Paradoxical activation of RAF signaling by kinase inactive BRAF
reactomeR-HSA-6802957Oncogenic MAPK signaling
reactomeR-HSA-6806834Signaling by MET
reactomeR-HSA-74751Insulin receptor signalling cascade
reactomeR-HSA-74752Signaling by Insulin receptor
reactomeR-HSA-881907Gastrin-CREB signalling pathway via PKC and MAPK
reactomeR-HSA-8848021Signaling by PTK6
reactomeR-HSA-8849471PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
reactomeR-HSA-8851805MET activates RAS signaling
reactomeR-HSA-8853334Signaling by FGFR3 fusions in cancer
reactomeR-HSA-8853338Signaling by FGFR3 point mutants in cancer
reactomeR-HSA-9006115Signaling by NTRK2 (TRKB)
reactomeR-HSA-9006927Signaling by Non-Receptor Tyrosine Kinases
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9026519Activated NTRK2 signals through RAS
reactomeR-HSA-9028731Activated NTRK2 signals through FRS2 and FRS3
reactomeR-HSA-9034015Signaling by NTRK3 (TRKC)
reactomeR-HSA-9034864Activated NTRK3 signals through RAS
reactomeR-HSA-983705Signaling by the B Cell Receptor (BCR)
humancycPWY66-14MAP kinase cascade
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04012ErbB signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04062Chemokine signaling pathway - Homo sapiens (human)
kegghsa04068FoxO signaling pathway - Homo sapiens (human)
kegghsa04071Sphingolipid signaling pathway - Homo sapiens (human)
kegghsa04072Phospholipase D signaling pathway - Homo sapiens (human)
kegghsa04137Mitophagy - animal - Homo sapiens (human)
kegghsa04140Autophagy - animal - Homo sapiens (human)
kegghsa04144Endocytosis - Homo sapiens (human)
kegghsa04150mTOR signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04210Apoptosis - Homo sapiens (human)
kegghsa04211Longevity regulating pathway - Homo sapiens (human)
kegghsa04213Longevity regulating pathway - multiple species - Homo sapiens (human)
kegghsa04218Cellular senescence - Homo sapiens (human)
kegghsa04360Axon guidance - Homo sapiens (human)
kegghsa04370VEGF signaling pathway - Homo sapiens (human)
kegghsa04371Apelin signaling pathway - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa04540Gap junction - Homo sapiens (human)
kegghsa04550Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
kegghsa04625C-type lectin receptor signaling pathway - Homo sapiens (human)
kegghsa04630Jak-STAT signaling pathway - Homo sapiens (human)
kegghsa04650Natural killer cell mediated cytotoxicity - Homo sapiens (human)
kegghsa04660T cell receptor signaling pathway - Homo sapiens (human)
kegghsa04662B cell receptor signaling pathway - Homo sapiens (human)
kegghsa04664Fc epsilon RI signaling pathway - Homo sapiens (human)
kegghsa04714Thermogenesis - Homo sapiens (human)
kegghsa04720Long-term potentiation - Homo sapiens (human)
kegghsa04722Neurotrophin signaling pathway - Homo sapiens (human)
kegghsa04725Cholinergic synapse - Homo sapiens (human)
kegghsa04726Serotonergic synapse - Homo sapiens (human)
kegghsa04730Long-term depression - Homo sapiens (human)
kegghsa04810Regulation of actin cytoskeleton - Homo sapiens (human)
kegghsa04910Insulin signaling pathway - Homo sapiens (human)
kegghsa04912GnRH signaling pathway - Homo sapiens (human)
kegghsa04915Estrogen signaling pathway - Homo sapiens (human)
kegghsa04916Melanogenesis - Homo sapiens (human)
kegghsa04917Prolactin signaling pathway - Homo sapiens (human)
kegghsa04919Thyroid hormone signaling pathway - Homo sapiens (human)
kegghsa04921Oxytocin signaling pathway - Homo sapiens (human)
kegghsa04926Relaxin signaling pathway - Homo sapiens (human)
kegghsa04933AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
kegghsa05034Alcoholism - Homo sapiens (human)
kegghsa05160Hepatitis C - Homo sapiens (human)
kegghsa05161Hepatitis B - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05203Viral carcinogenesis - Homo sapiens (human)
kegghsa05205Proteoglycans in cancer - Homo sapiens (human)
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)
kegghsa05210Colorectal cancer - Homo sapiens (human)
kegghsa05211Renal cell carcinoma - Homo sapiens (human)
kegghsa05213Endometrial cancer - Homo sapiens (human)
kegghsa05214Glioma - Homo sapiens (human)
kegghsa05215Prostate cancer - Homo sapiens (human)
kegghsa05216Thyroid cancer - Homo sapiens (human)
kegghsa05218Melanoma - Homo sapiens (human)
kegghsa05219Bladder cancer - Homo sapiens (human)
kegghsa05220Chronic myeloid leukemia - Homo sapiens (human)
kegghsa05221Acute myeloid leukemia - Homo sapiens (human)
kegghsa05223Non-small cell lung cancer - Homo sapiens (human)
kegghsa05224Breast cancer - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
kegghsa05226Gastric cancer - Homo sapiens (human)
kegghsa05230Central carbon metabolism in cancer - Homo sapiens (human)
kegghsa05231Choline metabolism in cancer - Homo sapiens (human)
wikipathwaysWP185Integrin-mediated Cell Adhesion
wikipathwaysWP2032Human Thyroid Stimulating Hormone (TSH) signaling pathway
wikipathwaysWP2034Leptin signaling pathway
wikipathwaysWP2037Prolactin Signaling Pathway
wikipathwaysWP2261Signaling Pathways in Glioblastoma
wikipathwaysWP2263Androgen Receptor Network in Prostate Cancer
wikipathwaysWP2290RalA downstream regulated genes
wikipathwaysWP23B Cell Receptor Signaling Pathway
wikipathwaysWP231TNF alpha Signaling Pathway
wikipathwaysWP2332Interleukin-11 Signaling Pathway
wikipathwaysWP2374Oncostatin M Signaling Pathway
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathwaysWP244Alpha 6 Beta 4 signaling pathway
wikipathwaysWP2526PDGF Pathway
wikipathwaysWP2586Aryl Hydrocarbon Receptor
wikipathwaysWP2828Bladder Cancer
wikipathwaysWP286IL-3 Signaling Pathway
wikipathwaysWP2870Extracellular vesicle-mediated signaling in recipient cells
wikipathwaysWP304Kit receptor signaling pathway
wikipathwaysWP306Focal Adhesion
wikipathwaysWP313Signaling of Hepatocyte Growth Factor Receptor
wikipathwaysWP3303Rac1-Pak1-p38-MMP-2 pathway
wikipathwaysWP35G Protein Signaling Pathways
wikipathwaysWP3651Pathways Affected in Adenoid Cystic Carcinoma
wikipathwaysWP3676BDNF-TrkB Signaling
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3844PI3K-AKT-mTOR signaling pathway and therapeutic opportunities
wikipathwaysWP3853ERK Pathway in Huntington,s Disease
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP3915Angiopoietin Like Protein 8 Regulatory Pathway
wikipathwaysWP3929Chemokine signaling pathway
wikipathwaysWP3931ESC Pluripotency Pathways
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP3972PDGFR-beta pathway
wikipathwaysWP400p38 MAPK Signaling Pathway
wikipathwaysWP4155Endometrial cancer
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP4205MET in type 1 papillary renal cell carcinoma
wikipathwaysWP422MAPK Cascade
wikipathwaysWP4223Ras Signaling
wikipathwaysWP4239EMT transition in Colorectal Cancer
wikipathwaysWP437EGF-EGFR Signaling Pathway
wikipathwaysWP481Insulin Signaling
wikipathwaysWP49IL-2 Signaling Pathway
wikipathwaysWP560TGF-beta Receptor Signaling
wikipathwaysWP615Senescence and Autophagy in Cancer
wikipathwaysWP673ErbB Signaling Pathway
wikipathwaysWP69T-Cell antigen Receptor (TCR) Signaling Pathway
wikipathwaysWP710DNA Damage Response (only ATM dependent)
wikipathwaysWP732Serotonin Receptor 2 and ELK-SRF-GATA4 signaling
smpdbSMP00320Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
smpdbSMP00321Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
smpdbSMP00358Fc Epsilon Receptor I Signaling in Mast Cells
smpdbSMP00391Insulin Signalling
pida6b1_a6b4_integrin_pathwaya6b1 and a6b4 Integrin signaling
pidajdiss_2pathwayPosttranslational regulation of adherens junction stability and dissassembly
pidar_nongenomic_pathwayNongenotropic Androgen signaling
pidbcr_5pathwayBCR signaling pathway
pidcd8tcrdownstreampathwayDownstream signaling in naïve CD8+ T cells
pidcd8tcrpathwayTCR signaling in naïve CD8+ T cells
pidcdc42_pathwayCDC42 signaling events
pidcmyb_pathwayC-MYB transcription factor network
pidcxcr3pathwayCXCR3-mediated signaling events
pidephbfwdpathwayEPHB forward signaling
pidepopathwayEPO signaling pathway
pider_nongenomic_pathwayPlasma membrane estrogen receptor signaling
piderbb1_downstream_pathwayErbB1 downstream signaling
piderbb1_internalization_pathwayInternalization of ErbB1
piderbb2erbb3pathwayErbB2/ErbB3 signaling events
pidet_egfrpathwayEGFR-dependent Endothelin signaling events
pidfcer1pathwayFc-epsilon receptor I signaling in mast cells
pidgmcsf_pathwayGMCSF-mediated signaling events
pidigf1_pathwayIGF1 pathway
pidil2_1pathwayIL2-mediated signaling events
pidinsulin_pathwayInsulin Pathway
pidkitpathwaySignaling events mediated by Stem cell factor receptor (c-Kit)
pidlysophospholipid_pathwayLPA receptor mediated events
pidmapktrkpathwayTrk receptor signaling mediated by the MAPK pathway
pidmet_pathwaySignaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
pidmtor_4pathwaymTOR signaling pathway
pidpdgfrbpathwayPDGFR-beta signaling pathway
pidpi3kcipathwayClass I PI3K signaling events
pidpi3kplctrkpathwayTrk receptor signaling mediated by PI3K and PLC-gamma
pidras_pathwayRegulation of Ras family activation
pidret_pathwaySignaling events regulated by Ret tyrosine kinase
pidshp2_pathwaySHP2 signaling
pidsyndecan_2_pathwaySyndecan-2-mediated signaling events
pidtcr_pathwayTCR signaling in naïve CD4+ T cells
pidtcrraspathwayRas signaling in the CD4+ TCR pathway
pidtrkrpathwayNeurotrophic factor-mediated Trk receptor signaling
pharmgkbPA154423660Bisphosphonate Pathway, Pharmacodynamics
pharmgkbPA162356267EGFR Inhibitor Pathway, Pharmacodynamics
pharmgkbPA165959584Sorafenib Pharmacodynamics
pharmgkbPA165980050Vemurafenib Pathway, Pharmacodynamics
pharmgkbPA165980050update your name in edit mode
pharmgkbPA2032VEGF Signaling Pathway

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD372TGX 2211
iGMDRD267Oligomycin A3
iGMDRD333MEK Inhibitor6
iGMDRD983PI3K pathway inhibitor2
iGMDRD949mTOR inhibitor6
iGMDRD894EGFR inhibitor1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HRAS