TTYH2


Summary: This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion channels. The encoded protein functions as a calcium(2+)-activated large conductance chloride(-) channel, and may play a role in kidney tumorigenesis. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
tweety family member 2MIM:608855Ensembl:ENSG00000141540HGNC:HGNC:13877PA3782317q25.1

Gene Categories:

ION CHANNELTRANSPORTER

GO terms in TTYH2


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0005229intracellular calcium activated chloride channel activity
MFIEAGO:0005254chloride channel activity
MFIPIGO:0005515protein binding
MFIBAGO:0072320volume-sensitive chloride channel activity
CCIBAGO:0005886plasma membrane
CCIEAGO:0005886plasma membrane
CCIEAGO:0034707chloride channel complex
BPIEAGO:1902476chloride transmembrane transport

Gene expression in normal tissue: TTYH2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TTYH2


DatabasePathway IDPathway Des.
reactomeR-HSA-2672351Stimuli-sensing channels
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-983712Ion channel transport

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD284Palbociclib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TTYH2

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