TTYH2
Summary: This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion channels. The encoded protein functions as a calcium(2+)-activated large conductance chloride(-) channel, and may play a role in kidney tumorigenesis. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:608855 Ensembl IDEnsembl:ENSG00000141540 HGNC IDHGNC:HGNC:13877 PHARMGKB IDPA37823 Map Location17q25.1 | |||||
GO terms in TTYH2
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0005229 | intracellular calcium activated chloride channel activity |
| MF | IEA | GO:0005254 | chloride channel activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0072320 | volume-sensitive chloride channel activity |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | IEA | GO:0005886 | plasma membrane |
Gene expression in normal tissue: TTYH2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TTYH2
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-2672351 | Stimuli-sensing channels |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-983712 | Ion channel transport |
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Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD284 | Palbociclib | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TTYH2
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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