HSD17B12
Summary: This gene encodes a very important 17beta-hydroxysteroid dehydrogenase (17beta-HSD) that converts estrone into estradiol in ovarian tissue. This enzyme is also involved in fatty acid elongation. [provided by RefSeq, Oct 2011].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:609574 Ensembl IDEnsembl:ENSG00000149084 HGNC IDHGNC:HGNC:18646 PHARMGKB IDPA38618 Map Location11p11.2 | |||||
GO terms in HSD17B12
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0001968 | fibronectin binding |
| MF | IEA | GO:0004303 | estradiol 17-beta-dehydrogenase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005518 | collagen binding |
| MF | IEA | GO:0008201 | heparin binding |
| MF | EXP | GO:0016509 | long-chain-3-hydroxyacyl-CoA dehydrogenase activity |
Gene expression in normal tissue: HSD17B12
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HSD17B12
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2006 | miR-targeted genes in squamous cell - TarBase |
| kegg | hsa00062 | Fatty acid elongation - Homo sapiens (human) |
| kegg | hsa00140 | Steroid hormone biosynthesis - Homo sapiens (human) |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD284 | Palbociclib | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HSD17B12
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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