HSD17B12


Summary: This gene encodes a very important 17beta-hydroxysteroid dehydrogenase (17beta-HSD) that converts estrone into estradiol in ovarian tissue. This enzyme is also involved in fatty acid elongation. [provided by RefSeq, Oct 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
hydroxysteroid 17-beta dehydrogenase 12MIM:609574Ensembl:ENSG00000149084HGNC:HGNC:18646PA3861811p11.2

GO terms in HSD17B12


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0001968fibronectin binding
MFIEAGO:0004303estradiol 17-beta-dehydrogenase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005518collagen binding
MFIEAGO:0008201heparin binding
MFEXPGO:0016509long-chain-3-hydroxyacyl-CoA dehydrogenase activity
MFIBAGO:0016509long-chain-3-hydroxyacyl-CoA dehydrogenase activity
MFIEAGO:01023393-oxo-arachidoyl-CoA reductase activity
MFIEAGO:01023403-oxo-behenoyl-CoA reductase activity
MFIEAGO:01023413-oxo-lignoceroyl-CoA reductase activity
MFIEAGO:01023423-oxo-cerotoyl-CoA reductase activity
BPIEAGO:0006633fatty acid biosynthetic process
BPIEAGO:0006703estrogen biosynthetic process
BPIEAGO:0010811positive regulation of cell-substrate adhesion
BPIEAGO:0030198extracellular matrix organization
BPTASGO:0035338long-chain fatty-acyl-CoA biosynthetic process
BPIEAGO:0055114oxidation-reduction process
CCTASGO:0005789endoplasmic reticulum membrane
CCIEAGO:0016021integral component of membrane

Gene expression in normal tissue: HSD17B12

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in HSD17B12


DatabasePathway IDPathway Des.
wikipathwaysWP2002miR-targeted genes in epithelium - TarBase
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase
wikipathwaysWP2005miR-targeted genes in muscle cell - TarBase
wikipathwaysWP2006miR-targeted genes in squamous cell - TarBase
kegghsa00062Fatty acid elongation - Homo sapiens (human)
kegghsa00140Steroid hormone biosynthesis - Homo sapiens (human)
kegghsa01040Biosynthesis of unsaturated fatty acids - Homo sapiens (human)
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-193048Androgen biosynthesis
reactomeR-HSA-196071Metabolism of steroid hormones
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-75105Fatty acyl-CoA biosynthesis
reactomeR-HSA-75876Synthesis of very long-chain fatty acyl-CoAs
reactomeR-HSA-8957322Metabolism of steroids
reactomeR-HSA-8978868Fatty acid metabolism

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD284Palbociclib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HSD17B12

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