SEARCH

HOME / SEARCH / RAB11FIP4

RAB11FIP4

Summary: The protein encoded by this gene interacts with RAB11 and is thought to be involved in bringing recycling endosome membranes to the cleavage furrow in late cytokinesis. Hypoxic conditions can lead to an upregulation of the encoded protein and enhance the metastatic potential of hepatocellular carcinoma. [provided by RefSeq, Oct 2016].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
RAB11 family interacting protein 4	MIM:611999	Ensembl:ENSG00000131242	HGNC:HGNC:30267	PA134978007	17q11.2

Gene Categories:

CELL SURFACE TUMOR SUPPRESSOR

GO terms in RAB11FIP4

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IEA	GO:0005509	calcium ion binding
MF	IPI	GO:0005515	protein binding
MF	IBA	GO:0017137	Rab GTPase binding
MF	IPI	GO:0017137	Rab GTPase binding
MF	IBA	GO:0030306	ADP-ribosylation factor binding
MF	IPI	GO:0030306	ADP-ribosylation factor binding
MF	IDA	GO:0042803	protein homodimerization activity
CC	HDA	GO:0005615	extracellular space
CC	IDA	GO:0005768	endosome
CC	IBA	GO:0005813	centrosome
CC	IEA	GO:0005815	microtubule organizing center
CC	IEA	GO:0005819	spindle
CC	IBA	GO:0030139	endocytic vesicle
CC	IDA	GO:0030139	endocytic vesicle
CC	IBA	GO:0030496	midbody
CC	IDA	GO:0030496	midbody
CC	IBA	GO:0032154	cleavage furrow
CC	IDA	GO:0032154	cleavage furrow
CC	IEA	GO:0048471	perinuclear region of cytoplasm
CC	IBA	GO:0055038	recycling endosome membrane
CC	IDA	GO:0055038	recycling endosome membrane
BP	IEA	GO:0003407	neural retina development
BP	IEA	GO:0016032	viral process
BP	IBA	GO:0032456	endocytic recycling
BP	IMP	GO:0032465	regulation of cytokinesis
BP	IEA	GO:1903452	positive regulation of G1 to G0 transition

Gene expression in normal tissue: RAB11FIP4

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RAB11FIP4

Database	Pathway ID	Pathway Des.
kegg	hsa04144	Endocytosis - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD284	Palbociclib	1
iGMDRD309	17AAG	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RAB11FIP4

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.