SPTBN4


Summary: Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein localizes to the nuclear matrix, PML nuclear bodies, and cytoplasmic vesicles. A highly similar gene in the mouse is required for localization of specific membrane proteins in polarized regions of neurons. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
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GO terms in SPTBN4


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IDA GO:0005737 cytoplasm
CC ISS GO:0005737 cytoplasm
CC TAS GO:0005829 cytosol
CC ISS GO:0005886 plasma membrane
CC ISS GO:0005912 adherens junction
CC IDA GO:0008091 spectrin
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Gene expression in normal tissue: SPTBN4

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

Cell cycle1

Pathways in SPTBN4


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1266738 Developmental Biology
reactome R-HSA-1266738 Developmental Biology
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-199977 ER to Golgi Anterograde Transport
reactome R-HSA-199991 Membrane Trafficking
reactome R-HSA-373760 L1CAM interactions
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD284 Palbociclib 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SPTBN4

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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