SLC20A1

Summary: The protein encoded by this gene is a sodium-phosphate symporter that absorbs phosphate from interstitial fluid for use in cellular functions such as metabolism, signal transduction, and nucleic acid and lipid synthesis. The encoded protein is also a retroviral receptor, causing human cells to be susceptible to infection by gibbon ape leukemia virus, simian sarcoma-associated virus, feline leukemia virus subgroup B, and 10A1 murine leukemia virus.[provided by RefSeq, Mar 2011].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namesolute carrier family 20 member 1
OMIM IDMIM:137570
Ensembl IDEnsembl:ENSG00000144136
HGNC IDHGNC:HGNC:10946
PHARMGKB IDPA35833
Map Location2q14.1

Gene Categories:

TRANSPORTER

GO terms in SLC20A1


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Term Type
Evidence Type
GO Term ID
GO Des.
BP TAS GO:0006796 phosphate-containing compound metabolic process
BP TAS GO:0006811 ion transport
BP IEA GO:0007165 signal transduction
BP IBA GO:0035435 phosphate ion transmembrane transport
BP IEA GO:0035725 sodium ion transmembrane transport
BP HMP GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
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Gene expression in normal tissue: SLC20A1

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 2

Gene-drug pathway distribution

Cell cycle1ERK MAPK signaling1

Pathways in SLC20A1


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Database
Pathway ID
Pathway Des.
reactome R-HSA-382551 Transport of small molecules
reactome R-HSA-425393 Transport of inorganic cations/anions and amino acids/oligopeptides
reactome R-HSA-425407 SLC-mediated transmembrane transport
reactome R-HSA-427652 Sodium-coupled phosphate cotransporters
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 1
iGMDRD284 Palbociclib 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SLC20A1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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