FARP1
Summary: This gene encodes a protein containing a FERM (4.2, exrin, radixin, moesin) domain, a Dbl homology domain, and two pleckstrin homology domains. These domains are found in guanine nucleotide exchange factors and proteins that link the cytoskeleton to the cell membrane. The encoded protein functions in neurons to promote dendritic growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
FERM, ARH/RhoGEF and pleckstrin domain protein 1 | MIM:602654 | Ensembl:ENSG00000152767 | HGNC:HGNC:3591 | PA28004 | 13q32.2 |
GO terms in FARP1
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
BP | ISS | GO:0007416 | synapse assembly |
BP | IDA | GO:0010923 | negative regulation of phosphatase activity |
BP | IEA | GO:0035023 | regulation of Rho protein signal transduction |
BP | ISS | GO:0048813 | dendrite morphogenesis |
CC | ISS | GO:0005829 | cytosol |
CC | IEA | GO:0005856 | cytoskeleton |
CC | IEA | GO:0030054 | cell junction |
CC | IEA | GO:0030175 | filopodium |
CC | ISS | GO:0030425 | dendrite |
CC | ISS | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane |
CC | IEA | GO:0043197 | dendritic spine |
MF | TAS | GO:0005089 | Rho guanyl-nucleotide exchange factor activity |
MF | IEA | GO:0008092 | cytoskeletal protein binding |
MF | ISS | GO:0030676 | Rac guanyl-nucleotide exchange factor activity |
Gene expression in normal tissue: FARP1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Gene in drug-gene network: Network Plot
![](image/gene_network_legends.png)
Gene-drug targets distribution
Gene Structure: PDB
Models in FARP1