FARP1

Summary: This gene encodes a protein containing a FERM (4.2, exrin, radixin, moesin) domain, a Dbl homology domain, and two pleckstrin homology domains. These domains are found in guanine nucleotide exchange factors and proteins that link the cytoskeleton to the cell membrane. The encoded protein functions in neurons to promote dendritic growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameFERM, ARH/RhoGEF and pleckstrin domain protein 1
OMIM IDMIM:602654
Ensembl IDEnsembl:ENSG00000152767
HGNC IDHGNC:HGNC:3591
PHARMGKB IDPA28004
Map Location13q32.2

GO terms in FARP1


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Term Type
Evidence Type
GO Term ID
GO Des.
BP ISS GO:0007416 synapse assembly
BP IDA GO:0010923 negative regulation of phosphatase activity
BP IEA GO:0035023 regulation of Rho protein signal transduction
BP ISS GO:0048813 dendrite morphogenesis
CC ISS GO:0005829 cytosol
CC IEA GO:0005856 cytoskeleton
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Gene expression in normal tissue: FARP1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FARP1


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Database
Pathway ID
Pathway Des.
pid rhoa_reg_pathway Regulation of RhoA activity
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD284 Palbociclib 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FARP1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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