SLN
Summary: Sarcoplasmic reticulum Ca(2+)-ATPases are transmembrane proteins that catalyze the ATP-dependent transport of Ca(2+) from the cytosol into the lumen of the sarcoplasmic reticulum in muscle cells. This gene encodes a small proteolipid that regulates several sarcoplasmic reticulum Ca(2+)-ATPases. The transmembrane protein interacts with Ca(2+)-ATPases and reduces the accumulation of Ca(2+) in the sarcoplasmic reticulum without affecting the rate of ATP hydrolysis. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| sarcolipin | MIM:602203 | Ensembl:ENSG00000170290 | HGNC:HGNC:11089 | PA35942 | 11q22.3 |
GO terms in SLN
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISS | GO:0004857 | enzyme inhibitor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | ISS | GO:0051117 | ATPase binding |
| BP | NAS | GO:0006816 | calcium ion transport |
| BP | ISS | GO:0043086 | negative regulation of catalytic activity |
| BP | ISS | GO:0043242 | negative regulation of protein complex disassembly |
| BP | ISS | GO:0051924 | regulation of calcium ion transport |
| BP | ISS | GO:0070296 | sarcoplasmic reticulum calcium ion transport |
| BP | ISS | GO:0090281 | negative regulation of calcium ion import |
| BP | ISS | GO:1901020 | negative regulation of calcium ion transmembrane transporter activity |
| BP | ISS | GO:1901077 | regulation of relaxation of muscle |
| BP | ISS | GO:1901877 | negative regulation of calcium ion binding |
| BP | ISS | GO:1901881 | positive regulation of protein depolymerization |
| BP | IDA | GO:1901894 | regulation of calcium-transporting ATPase activity |
| CC | NAS | GO:0016021 | integral component of membrane |
| CC | IDA | GO:0016529 | sarcoplasmic reticulum |
| CC | ISS | GO:0033017 | sarcoplasmic reticulum membrane |
Gene expression in normal tissue: SLN
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SLN
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-397014 | Muscle contraction |
| reactome | R-HSA-5576891 | Cardiac conduction |
| reactome | R-HSA-5578775 | Ion homeostasis |
| reactome | R-HSA-936837 | Ion transport by P-type ATPases |
| reactome | R-HSA-983712 | Ion channel transport |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SLN
CLASSFICATION
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