SLC2A4
Summary: This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM). [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:138190 Ensembl IDEnsembl:ENSG00000181856 HGNC IDHGNC:HGNC:11009 PHARMGKB IDPA35879 Map Location17p13.1 | |||||
GO terms in SLC2A4
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0005771 | multivesicular body |
| CC | IEA | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0005887 | integral component of plasma membrane |
| CC | IEA | GO:0005905 | clathrin-coated pit |
Gene expression in normal tissue: SLC2A4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SLC2A4
Database | Pathway ID | Pathway Des. |
|---|---|---|
| pharmgkb | PA165948566 | Metformin Pathway, Pharmacodynamic |
| pid | arf6_traffickingpathway | Arf6 trafficking events |
| pid | insulin_glucose_pathway | Insulin-mediated glucose transport |
| pid | pi3kciaktpathway | Class I PI3K signaling events mediated by Akt |
| netpath | Pathway_Leptin | Leptin |
| kegg | hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD284 | Palbociclib | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SLC2A4
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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