WNK3
Summary: This gene encodes a protein belonging to the 'with no lysine' family of serine-threonine protein kinases. These family members lack the catalytic lysine in subdomain II, and instead have a conserved lysine in subdomain I. This family member functions as a positive regulator of the transcellular Ca2+ transport pathway, and it plays a role in the increase of cell survival in a caspase-3-dependent pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| WNK lysine deficient protein kinase 3 | MIM:300358 | Ensembl:ENSG00000196632 | HGNC:HGNC:14543 | PA33784 | Xp11.22 |
GO terms in WNK3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | ISS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | ISS | GO:0005524 | ATP binding |
| MF | IDA | GO:0019869 | chloride channel inhibitor activity |
| BP | IBA | GO:0006468 | protein phosphorylation |
| BP | ISS | GO:0006468 | protein phosphorylation |
| BP | IDA | GO:0010765 | positive regulation of sodium ion transport |
| BP | IDA | GO:0010800 | positive regulation of peptidyl-threonine phosphorylation |
| BP | IBA | GO:0032414 | positive regulation of ion transmembrane transporter activity |
| BP | IDA | GO:0032414 | positive regulation of ion transmembrane transporter activity |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| BP | ISS | GO:0035556 | intracellular signal transduction |
| BP | IMP | GO:0043066 | negative regulation of apoptotic process |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | IMP | GO:0050801 | ion homeostasis |
| BP | IBA | GO:0051928 | positive regulation of calcium ion transport |
| BP | IMP | GO:0051928 | positive regulation of calcium ion transport |
| BP | IMP | GO:0072659 | protein localization to plasma membrane |
| BP | IEA | GO:0090188 | negative regulation of pancreatic juice secretion |
| BP | IMP | GO:0090279 | regulation of calcium ion import |
| BP | IDA | GO:1903078 | positive regulation of protein localization to plasma membrane |
| BP | IDA | GO:2000651 | positive regulation of sodium ion transmembrane transporter activity |
| BP | IMP | GO:2000651 | positive regulation of sodium ion transmembrane transporter activity |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IBA | GO:0005829 | cytosol |
| CC | ISS | GO:0005912 | adherens junction |
| CC | ISS | GO:0005923 | bicellular tight junction |
Gene expression in normal tissue: WNK3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in WNK3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-2672351 | Stimuli-sensing channels |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-983712 | Ion channel transport |
| pharmgkb | PA165984799 | Diuretics Pathway, Pharmacodynamics |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD341 | Triacsin c | 2 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD307 | Manumycin A | 3 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD286 | Nsc 632839 | 1 |
| iGMDRD872 | BRD7137 | 1 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD552 | AZD-1775 | 2 |
| iGMDRD353 | PD0325901 | 2 |
| iGMDRD137 | Indisulam | 6 |
| iGMDRD202 | Curcumin | 6 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD705 | Nakiterpiosin | 4 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD434 | BMS-536924 | 4 |
| iGMDRD280 | CYTOCHALASIN B | 4 |
| iGMDRD599 | Salermide | 3 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD188 | Piperlongumine | 4 |
| iGMDRD100 | Zebularine | 5 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD562 | Navitoclax | 8 |
| iGMDRD513 | BML-259 | 1 |
| iGMDRD802 | 4-methylfasudil | 3 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD284 | Palbociclib | 1 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD187 | BRD9876 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in WNK3
CLASSFICATION
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