SEARCH

HOME / SEARCH / MDM2

MDM2

Summary: This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013].

Loading, please wait...

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
NameMDM2 proto-oncogene OMIM IDMIM:164785 Ensembl IDEnsembl:ENSG00000135679 HGNC IDHGNC:HGNC:6973 PHARMGKB IDPA30718 Map Location12q15

Gene Categories:

CLINICALLY ACTIONABLE TUMOR SUPPRESSOR PROTEASE DRUG RESISTANCE DRUGGABLE GENOME

GO terms in MDM2

Loading, please wait...

Term Type	Evidence Type	GO Term ID	GO Des.
BP	IDA	GO:0000122	negative regulation of transcription by RNA polymerase II
BP	IEA	GO:0001568	blood vessel development
BP	IEA	GO:0001974	blood vessel remodeling
BP	IEA	GO:0002027	regulation of heart rate
BP	IEA	GO:0003181	atrioventricular valve morphogenesis
BP	IEA	GO:0003203	endocardial cushion morphogenesis

Showing 1 to 6 of 102 rows rows per page

Gene expression in normal tissue: MDM2

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MDM2

Loading, please wait...

Database	Pathway ID	Pathway Des.
reactome	R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission
reactome	R-HSA-112315	Transmission across Chemical Synapses
reactome	R-HSA-112316	Neuronal System
reactome	R-HSA-1257604	PIP3 activates AKT signaling
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-1640170	Cell Cycle

Showing 1 to 6 of 109 rows rows per page

Gene-Drug: Aster Plot

Loading, please wait...

Drug ID	Drug Name	Model Num.
iGMDRD499	PDMP	1
iGMDRD352	PD-0325901	1
iGMDRD536	PLX-4720	1
iGMDRD85	Ursolic acid	1

Showing 1 to 4 of 48 rows rows per page

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MDM2

Loading, please wait...

	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
No matching records found

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.