STON2
Summary: This gene encodes a protein which is a membrane protein involved in regulating endocytotic complexes. The protein product is described as one of the clathrin-associated sorting proteins, adaptor molecules which ensure specific proteins are internalized. The encoded protein has also been shown to participate in synaptic vesicle recycling through interaction with synaptotagmin 1 required for neurotransmission. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| stonin 2 | MIM:608467 | Ensembl:ENSG00000140022 | HGNC:HGNC:30652 | PA143485624 | 14q31.1 |
GO terms in STON2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0002244 | hematopoietic progenitor cell differentiation |
| BP | IBA | GO:0030100 | regulation of endocytosis |
| BP | ISS | GO:0030100 | regulation of endocytosis |
| BP | IGI | GO:0048488 | synaptic vesicle endocytosis |
| BP | TAS | GO:0061024 | membrane organization |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0008021 | synaptic vesicle |
| CC | IEA | GO:0016020 | membrane |
| CC | IEA | GO:0030054 | cell junction |
| CC | IEA | GO:0030136 | clathrin-coated vesicle |
| CC | IEA | GO:0043005 | neuron projection |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: STON2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in STON2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis |
| reactome | R-HSA-8856828 | Clathrin-mediated endocytosis |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in STON2
CLASSFICATION
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