STON2


Summary: This gene encodes a protein which is a membrane protein involved in regulating endocytotic complexes. The protein product is described as one of the clathrin-associated sorting proteins, adaptor molecules which ensure specific proteins are internalized. The encoded protein has also been shown to participate in synaptic vesicle recycling through interaction with synaptotagmin 1 required for neurotransmission. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
stonin 2MIM:608467Ensembl:ENSG00000140022HGNC:HGNC:30652PA14348562414q31.1

GO terms in STON2


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0002244hematopoietic progenitor cell differentiation
BPIBAGO:0030100regulation of endocytosis
BPISSGO:0030100regulation of endocytosis
BPIGIGO:0048488synaptic vesicle endocytosis
BPTASGO:0061024membrane organization
CCIDAGO:0005730nucleolus
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIEAGO:0008021synaptic vesicle
CCIEAGO:0016020membrane
CCIEAGO:0030054cell junction
CCIEAGO:0030136clathrin-coated vesicle
CCIEAGO:0043005neuron projection
MFIPIGO:0005515protein binding

Gene expression in normal tissue: STON2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in STON2


DatabasePathway IDPathway Des.
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-8856825Cargo recognition for clathrin-mediated endocytosis
reactomeR-HSA-8856828Clathrin-mediated endocytosis

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD284Palbociclib1
iGMDRD409Saracatinib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in STON2

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