ANOS1
Summary: Mutations in this gene cause the X-linked Kallmann syndrome. The encoded protein is similar in sequence to proteins known to function in neural cell adhesion and axonal migration. In addition, this cell surface protein is N-glycosylated and may have anti-protease activity. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| anosmin 1 | MIM:300836 | Ensembl:ENSG00000011201 | HGNC:HGNC:6211 | PA30012 | Xp22.31 |
GO terms in ANOS1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0006935 | chemotaxis |
| BP | IEA | GO:0007155 | cell adhesion |
| BP | TAS | GO:0007411 | axon guidance |
| BP | TAS | GO:0008543 | fibroblast growth factor receptor signaling pathway |
| BP | IEA | GO:0010951 | negative regulation of endopeptidase activity |
| CC | TAS | GO:0005576 | extracellular region |
| CC | TAS | GO:0005615 | extracellular space |
| CC | IEA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0031012 | extracellular matrix |
| MF | IEA | GO:0004867 | serine-type endopeptidase inhibitor activity |
| MF | TAS | GO:0005201 | extracellular matrix structural constituent |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008201 | heparin binding |
Gene expression in normal tissue: ANOS1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ANOS1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-190236 | Signaling by FGFR |
| reactome | R-HSA-190242 | FGFR1 ligand binding and activation |
| reactome | R-HSA-190373 | FGFR1c ligand binding and activation |
| reactome | R-HSA-5654726 | Negative regulation of FGFR1 signaling |
| reactome | R-HSA-5654736 | Signaling by FGFR1 |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ANOS1
CLASSFICATION
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