PPME1


Summary: This gene encodes a protein phosphatase methylesterase localized to the nucleus. The encoded protein acts on the protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory proteins. It plays a role in malignant glioma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012].

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OMIM ID
Ensembl ID
HGNC ID
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GO terms in PPME1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF TAS GO:0004864 protein phosphatase inhibitor activity
MF TAS GO:0019888 protein phosphatase regulator activity
MF IEA GO:0019901 protein kinase binding
MF IDA GO:0019903 protein phosphatase binding
MF HDA GO:0045296 cadherin binding
MF IDA GO:0051721 protein phosphatase 2A binding
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Gene expression in normal tissue: PPME1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PPME1


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1640170 Cell Cycle
reactome R-HSA-453274 Mitotic G2-G2/M phases
reactome R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition
reactome R-HSA-69275 G2/M Transition
reactome R-HSA-69278 Cell Cycle, Mitotic
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD284 Palbociclib 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PPME1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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