PPME1
Summary: This gene encodes a protein phosphatase methylesterase localized to the nucleus. The encoded protein acts on the protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory proteins. It plays a role in malignant glioma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein phosphatase methylesterase 1 | MIM:611117 | Ensembl:ENSG00000214517 | HGNC:HGNC:30178 | PA142671152 | 11q13.4 |
GO terms in PPME1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004864 | protein phosphatase inhibitor activity |
| MF | TAS | GO:0019888 | protein phosphatase regulator activity |
| MF | IEA | GO:0019901 | protein kinase binding |
| MF | IDA | GO:0019903 | protein phosphatase binding |
| MF | HDA | GO:0045296 | cadherin binding |
| MF | IDA | GO:0051721 | protein phosphatase 2A binding |
| MF | IDA | GO:0051722 | protein C-terminal methylesterase activity |
| MF | TAS | GO:0051722 | protein C-terminal methylesterase activity |
| MF | IBA | GO:0051723 | protein methylesterase activity |
| BP | TAS | GO:0000086 | G2/M transition of mitotic cell cycle |
| BP | IBA | GO:0006482 | protein demethylation |
| BP | IDA | GO:0006482 | protein demethylation |
| BP | IEA | GO:0032515 | negative regulation of phosphoprotein phosphatase activity |
| CC | TAS | GO:0005654 | nucleoplasm |
Gene expression in normal tissue: PPME1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PPME1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-453274 | Mitotic G2-G2/M phases |
| reactome | R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition |
| reactome | R-HSA-69275 | G2/M Transition |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PPME1
CLASSFICATION
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