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Summary: This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
protein C, inactivator of coagulation factors Va and VIIIa	MIM:612283	Ensembl:ENSG00000115718	HGNC:HGNC:9451	PA33799	2q14.3

Gene Categories:

PROTEASE DRUGGABLE GENOME

GO terms in PROC

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IBA	GO:0004252	serine-type endopeptidase activity
MF	IMP	GO:0004252	serine-type endopeptidase activity
MF	TAS	GO:0004252	serine-type endopeptidase activity
MF	IEA	GO:0005509	calcium ion binding
MF	IPI	GO:0005515	protein binding
BP	IEA	GO:0001889	liver development
BP	NAS	GO:0006508	proteolysis
BP	TAS	GO:0006888	ER to Golgi vesicle-mediated transport
BP	TAS	GO:0007596	blood coagulation
BP	IBA	GO:0030195	negative regulation of blood coagulation
BP	TAS	GO:0030195	negative regulation of blood coagulation
BP	IMP	GO:0043066	negative regulation of apoptotic process
BP	TAS	GO:0043687	post-translational protein modification
BP	TAS	GO:0044267	cellular protein metabolic process
BP	IEA	GO:0044537	regulation of circulating fibrinogen levels
BP	IMP	GO:0050728	negative regulation of inflammatory response
BP	IMP	GO:0050819	negative regulation of coagulation
BP	IMP	GO:1903142	positive regulation of establishment of endothelial barrier
CC	NAS	GO:0005576	extracellular region
CC	TAS	GO:0005576	extracellular region
CC	IBA	GO:0005615	extracellular space
CC	IDA	GO:0005783	endoplasmic reticulum
CC	TAS	GO:0005788	endoplasmic reticulum lumen
CC	IDA	GO:0005794	Golgi apparatus
CC	TAS	GO:0005796	Golgi lumen

Gene expression in normal tissue: PROC

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PROC

Database	Pathway ID	Pathway Des.
pid	integrin2_pathway	Beta2 integrin cell surface interactions
pharmgkb	PA145011114	Warfarin Pathway, Pharmacodynamics
kegg	hsa04610	Complement and coagulation cascades - Homo sapiens (human)
wikipathways	WP3896	Dengue-2 Interactions with Complement and Coagulation Cascades
wikipathways	WP558	Complement and Coagulation Cascades
reactome	R-HSA-109582	Hemostasis
reactome	R-HSA-140837	Intrinsic Pathway of Fibrin Clot Formation
reactome	R-HSA-140875	Common Pathway of Fibrin Clot Formation
reactome	R-HSA-140877	Formation of Fibrin Clot (Clotting Cascade)
reactome	R-HSA-159740	Gamma-carboxylation of protein precursors
reactome	R-HSA-159763	Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
reactome	R-HSA-159782	Removal of aminoterminal propeptides from gamma-carboxylated proteins
reactome	R-HSA-159854	Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
reactome	R-HSA-163841	Gamma carboxylation, hypusine formation and arylsulfatase activation
reactome	R-HSA-202733	Cell surface interactions at the vascular wall
reactome	R-HSA-381426	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
reactome	R-HSA-392499	Metabolism of proteins
reactome	R-HSA-597592	Post-translational protein modification
reactome	R-HSA-8957275	Post-translational protein phosphorylation
biocarta	extrinsicpathway	extrinsic prothrombin activation pathway
biocarta	gsk3pathway	inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages
biocarta	hespathway	segmentation clock
biocarta	intrinsicpathway	intrinsic prothrombin activation pathway
biocarta	pitx2pathway	multi-step regulation of transcription by pitx2
biocarta	tgfbpathway	tgf beta signaling pathway
biocarta	wntpathway	wnt signaling pathway

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD347	Y-39983	1
iGMDRD512	nutlin 3	1
iGMDRD307	Manumycin A	3
iGMDRD262	KU-55933	1
iGMDRD84	Lovastatin acid	2
iGMDRD382	CEP-701	1
iGMDRD497	16beta-Bromoandrosterone	3
iGMDRD652	UNC0638	3
iGMDRD345	Compound 10b [PMID: 11504634]	1
iGMDRD160	Cis-Platin	1
iGMDRD456	Crizotinib	1
iGMDRD536	PLX-4720	2
iGMDRD753	G007-LK	1
iGMDRD351	GW843682X	4
iGMDRD85	Ursolic acid	1
iGMDRD132	(-)-gallocatechin-3-O-gallate	2
iGMDRD177	Teniposide	2
iGMDRD1014	Tankyrase inhibitor	4
iGMDRD901	ELCPK	2
iGMDRD227	Fatostatin A	1
iGMDRD271	Brefeldin A	3
iGMDRD68	Paclitaxel	1
iGMDRD459	RO-3306	1
iGMDRD481	Dactolisib	1
iGMDRD565	BI-D1870	1
iGMDRD882	CIL41	3
iGMDRD414	MST-312	2
iGMDRD42	Vorinostat	2
iGMDRD353	PD0325901	1
iGMDRD82	Quiflapon	1
iGMDRD246	NPC26	6
iGMDRD300	Tozasertib	5
iGMDRD387	CHIR-99021	1
iGMDRD136	Nutlin-3	1
iGMDRD494	Neopeltolide	2
iGMDRD63	Camptothecin	1
iGMDRD163	all trans Retinoic Acid	1
iGMDRD201	SKI II	2
iGMDRD253	Vincaleukoblastine	1
iGMDRD230	JW 55	1
iGMDRD608	Refametinib	1
iGMDRD519	GDC-0941	1
iGMDRD378	ZM-447439	1
iGMDRD401	Afatinib	1
iGMDRD297	Austocystin D	5
iGMDRD134	Sorafenib	1
iGMDRD255	SB225002	5
iGMDRD613	CHEMBL258148	2
iGMDRD491	TAE-684	1
iGMDRD509	NVP-BHG712	1
iGMDRD870	BRD63610	5
iGMDRD574	Ruxolitinib	1
iGMDRD309	17AAG	1
iGMDRD782	DC-45-A2	2
iGMDRD398	Sepantronium	5
iGMDRD562	Navitoclax	8
iGMDRD185	DMOG	1
iGMDRD312	Pelitinib	1
iGMDRD131	Erlotinib	1
iGMDRD48	Dexamethasone	2
iGMDRD79	Gemcitabine	3
iGMDRD522	ML-030	3
iGMDRD594	AZD-8055	1
iGMDRD237	ABT-751	3
iGMDRD352	PD-0325901	1
iGMDRD341	Triacsin c	4
iGMDRD154	NSC23766	3
iGMDRD511	CHEMBL399379	2
iGMDRD605	AZD6482	2
iGMDRD251	ML162	2
iGMDRD121	GMX1778	1
iGMDRD202	Curcumin	2
iGMDRD158	NSC141540	3
iGMDRD77	Itraconazole	4
iGMDRD105	Triptolide	3
iGMDRD329	Merck60	2
iGMDRD119	Temsirolimus	1
iGMDRD871	BRD6368	2
iGMDRD286	Nsc 632839	3
iGMDRD322	FK 866	1
iGMDRD654	SL 0101-1	1
iGMDRD420	Leucascandrolide A	3
iGMDRD409	Saracatinib	1
iGMDRD151	CHM-1	2
iGMDRD76	Simvastatin	3
iGMDRD126	Tipifarnib	2
iGMDRD781	Sirolimus	3
iGMDRD779	PRL-3 Inhibitor I	2
iGMDRD546	BMS-754807	3
iGMDRD670	ML 210	2
iGMDRD427	ABT737	1
iGMDRD61	Kinetin riboside	1
iGMDRD748	PHA-665752	1
iGMDRD639	YK 4-279	1
iGMDRD394	BX-795	1
iGMDRD679	Bistramide A	2
iGMDRD474	Avrainvillamide	3
iGMDRD226	ML006	3
iGMDRD284	Palbociclib	2
iGMDRD117	Docetaxel	1
iGMDRD207	Capsaicin	3
iGMDRD146	Elesclomol	1
iGMDRD780	PP-30	2
iGMDRD888	Compound 44	3
iGMDRD730	Kahalalide F	4
iGMDRD399	Selumetinib	6
iGMDRD133	Lapatinib	2
iGMDRD874	BRD8958	2
iGMDRD64	Parbendazole	2
iGMDRD190	Nilotinib	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PROC

SITE

DATATYPES

CLASSFICATION

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