PROC


Summary: This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
protein C, inactivator of coagulation factors Va and VIIIaMIM:612283Ensembl:ENSG00000115718HGNC:HGNC:9451PA337992q14.3

Gene Categories:

PROTEASEDRUGGABLE GENOME

GO terms in PROC


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0004252serine-type endopeptidase activity
MFIMPGO:0004252serine-type endopeptidase activity
MFTASGO:0004252serine-type endopeptidase activity
MFIEAGO:0005509calcium ion binding
MFIPIGO:0005515protein binding
BPIEAGO:0001889liver development
BPNASGO:0006508proteolysis
BPTASGO:0006888ER to Golgi vesicle-mediated transport
BPTASGO:0007596blood coagulation
BPIBAGO:0030195negative regulation of blood coagulation
BPTASGO:0030195negative regulation of blood coagulation
BPIMPGO:0043066negative regulation of apoptotic process
BPTASGO:0043687post-translational protein modification
BPTASGO:0044267cellular protein metabolic process
BPIEAGO:0044537regulation of circulating fibrinogen levels
BPIMPGO:0050728negative regulation of inflammatory response
BPIMPGO:0050819negative regulation of coagulation
BPIMPGO:1903142positive regulation of establishment of endothelial barrier
CCNASGO:0005576extracellular region
CCTASGO:0005576extracellular region
CCIBAGO:0005615extracellular space
CCIDAGO:0005783endoplasmic reticulum
CCTASGO:0005788endoplasmic reticulum lumen
CCIDAGO:0005794Golgi apparatus
CCTASGO:0005796Golgi lumen

Gene expression in normal tissue: PROC

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PROC


DatabasePathway IDPathway Des.
pidintegrin2_pathwayBeta2 integrin cell surface interactions
pharmgkbPA145011114Warfarin Pathway, Pharmacodynamics
kegghsa04610Complement and coagulation cascades - Homo sapiens (human)
wikipathwaysWP3896Dengue-2 Interactions with Complement and Coagulation Cascades
wikipathwaysWP558Complement and Coagulation Cascades
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-140837Intrinsic Pathway of Fibrin Clot Formation
reactomeR-HSA-140875Common Pathway of Fibrin Clot Formation
reactomeR-HSA-140877Formation of Fibrin Clot (Clotting Cascade)
reactomeR-HSA-159740Gamma-carboxylation of protein precursors
reactomeR-HSA-159763Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
reactomeR-HSA-159782Removal of aminoterminal propeptides from gamma-carboxylated proteins
reactomeR-HSA-159854Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
reactomeR-HSA-163841Gamma carboxylation, hypusine formation and arylsulfatase activation
reactomeR-HSA-202733Cell surface interactions at the vascular wall
reactomeR-HSA-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-8957275Post-translational protein phosphorylation
biocartaextrinsicpathwayextrinsic prothrombin activation pathway
biocartagsk3pathwayinactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages
biocartahespathwaysegmentation clock
biocartaintrinsicpathwayintrinsic prothrombin activation pathway
biocartapitx2pathwaymulti-step regulation of transcription by pitx2
biocartatgfbpathwaytgf beta signaling pathway
biocartawntpathwaywnt signaling pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD347Y-399831
iGMDRD512nutlin 31
iGMDRD307Manumycin A3
iGMDRD262KU-559331
iGMDRD84Lovastatin acid2
iGMDRD382CEP-7011
iGMDRD49716beta-Bromoandrosterone3
iGMDRD652UNC06383
iGMDRD345Compound 10b [PMID: 11504634]1
iGMDRD160Cis-Platin1
iGMDRD456Crizotinib1
iGMDRD536PLX-47202
iGMDRD753G007-LK1
iGMDRD351GW843682X4
iGMDRD85Ursolic acid1
iGMDRD132(-)-gallocatechin-3-O-gallate2
iGMDRD177Teniposide2
iGMDRD1014Tankyrase inhibitor4
iGMDRD901ELCPK2
iGMDRD227Fatostatin A1
iGMDRD271Brefeldin A3
iGMDRD68Paclitaxel1
iGMDRD459RO-33061
iGMDRD481Dactolisib1
iGMDRD565BI-D18701
iGMDRD882CIL413
iGMDRD414MST-3122
iGMDRD42Vorinostat2
iGMDRD353PD03259011
iGMDRD82Quiflapon1
iGMDRD246NPC266
iGMDRD300Tozasertib5
iGMDRD387CHIR-990211
iGMDRD136Nutlin-31
iGMDRD494Neopeltolide2
iGMDRD63Camptothecin1
iGMDRD163all trans Retinoic Acid1
iGMDRD201SKI II2
iGMDRD253Vincaleukoblastine1
iGMDRD230JW 551
iGMDRD608Refametinib1
iGMDRD519GDC-09411
iGMDRD378ZM-4474391
iGMDRD401Afatinib1
iGMDRD297Austocystin D5
iGMDRD134Sorafenib1
iGMDRD255SB2250025
iGMDRD613CHEMBL2581482
iGMDRD491TAE-6841
iGMDRD509NVP-BHG7121
iGMDRD870BRD636105
iGMDRD574Ruxolitinib1
iGMDRD30917AAG1
iGMDRD782DC-45-A22
iGMDRD398Sepantronium5
iGMDRD562Navitoclax8
iGMDRD185DMOG1
iGMDRD312Pelitinib1
iGMDRD131Erlotinib1
iGMDRD48Dexamethasone2
iGMDRD79Gemcitabine3
iGMDRD522ML-0303
iGMDRD594AZD-80551
iGMDRD237ABT-7513
iGMDRD352PD-03259011
iGMDRD341Triacsin c4
iGMDRD154NSC237663
iGMDRD511CHEMBL3993792
iGMDRD605AZD64822
iGMDRD251ML1622
iGMDRD121GMX17781
iGMDRD202Curcumin2
iGMDRD158NSC1415403
iGMDRD77Itraconazole4
iGMDRD105Triptolide3
iGMDRD329Merck602
iGMDRD119Temsirolimus1
iGMDRD871BRD63682
iGMDRD286Nsc 6328393
iGMDRD322FK 8661
iGMDRD654SL 0101-11
iGMDRD420Leucascandrolide A3
iGMDRD409Saracatinib1
iGMDRD151CHM-12
iGMDRD76Simvastatin3
iGMDRD126Tipifarnib2
iGMDRD781Sirolimus3
iGMDRD779PRL-3 Inhibitor I2
iGMDRD546BMS-7548073
iGMDRD670ML 2102
iGMDRD427ABT7371
iGMDRD61Kinetin riboside1
iGMDRD748PHA-6657521
iGMDRD639YK 4-2791
iGMDRD394BX-7951
iGMDRD679Bistramide A2
iGMDRD474Avrainvillamide3
iGMDRD226ML0063
iGMDRD284Palbociclib2
iGMDRD117Docetaxel1
iGMDRD207Capsaicin3
iGMDRD146Elesclomol1
iGMDRD780PP-302
iGMDRD888Compound 443
iGMDRD730Kahalalide F4
iGMDRD399Selumetinib6
iGMDRD133Lapatinib2
iGMDRD874BRD89582
iGMDRD64Parbendazole2
iGMDRD190Nilotinib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PROC

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