PROC
Summary: This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:612283 Ensembl IDEnsembl:ENSG00000115718 HGNC IDHGNC:HGNC:9451 PHARMGKB IDPA33799 Map Location2q14.3 | |||||
GO terms in PROC
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004252 | serine-type endopeptidase activity |
| MF | IMP | GO:0004252 | serine-type endopeptidase activity |
| MF | TAS | GO:0004252 | serine-type endopeptidase activity |
| MF | IEA | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| BP | IEA | GO:0001889 | liver development |
Gene expression in normal tissue: PROC
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PROC
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | integrin2_pathway | Beta2 integrin cell surface interactions |
| pharmgkb | PA145011114 | Warfarin Pathway, Pharmacodynamics |
| kegg | hsa04610 | Complement and coagulation cascades - Homo sapiens (human) |
| wikipathways | WP3896 | Dengue-2 Interactions with Complement and Coagulation Cascades |
| wikipathways | WP558 | Complement and Coagulation Cascades |
| reactome | R-HSA-109582 | Hemostasis |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PROC
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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