iGMDRD565


Canonical SMILES: CC1C(=O)N(C2=CN=C(N=C2N1CCC(C)C)NC3=CC(=C(C(=C3)F)O)F)C

InChI: InChI=1S/C19H23F2N5O2/c1-10(2)5-6-26-11(3)18(28)25(4)15-9-22-19(24-17(15)26)23-12-7-13(20)16(27)14(21)8-12/h7-11,27H,5-6H2,1-4H3,(H,22,23,24)

InChI Key: DTEKTGDVSARYDS-UHFFFAOYSA-N

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Standard Name
CHEMBL
Pubchem CID
Drug Status
Drug Type
Standard NameBI-D1870
Pubchem CID25023700
Drug StatusAlone
Drug TypeSmall Molecule

Drug-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 4

Drug-gene pathway enrichments

5reactome: Signal Transduction4wikipathways: Notch Signaling Pathway4reactome: Generic Transcription Pathway4reactome: RNA Polymerase II Transcription4reactome: Transcriptional regulation by RUNX34reactome: Gene expression (Transcription)3reactome: Signaling by NOTCH13reactome: NOTCH1 Intracellular Domain Regulates Transcription3kegg: Pathways in cancer - Homo sapiens (human)3kegg: Breast cancer - Homo sapiens (human)

Drug-gene GO enrichments

5BP: positive regulation of transcription by RNA polymerase II4BP: positive regulation of cell proliferation4BP: positive regulation of gene expression4BP: Notch signaling pathway4MF: protein binding4MF: RNA polymerase II transcription factor activity, sequence-specific DNA binding3BP: aortic valve morphogenesis3CC: extracellular region3MF: serine-type endopeptidase activity3CC: nucleoplasm

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
3845 KRAS 1
4851 NOTCH1 1
4609 MYC 1
5624 PROC 1
Showing 1 to 4 of 4 rows

Gene in drug-gene network: Network Plot

PI-103PI-103BMS-754807BMS-754807Compound 44Compound 44ciclosporinciclosporintipifarnib-P2tipifarnib-P2itraconazoleitraconazoleCompound 110Compound 110Merck60Merck60SB225002SB225002bistramide Abistramide AnakiterpiosinnakiterpiosinYK.4.279YK.4.279VX-680VX-680(-)-gallocatechin-3-O-gallate(-)-gallocatechin-3-O-gallateBET inhibitorsBET inhibitorserastinerastinCD437CD437kahalalide Fkahalalide FMYCMYCPP-30PP-30selumetinib in BRAF mutant tumorsselumetinib in BRAF mutant tumorskinetin ribosidekinetin ribosideMEK inhibitorsMEK inhibitorsGefitnibGefitnibCHEMBL399379CHEMBL399379cetuximabcetuximabBMS-536924BMS-536924ErlotinibErlotinibPanitumumabPanitumumabPD0325901PD0325901NSC141540NSC141540PI3K pathway inhibitorsPI3K pathway inhibitorsSarcolysinSarcolysinRefametinibRefametinibRegorafenibRegorafenibTrametinibTrametinibKRASKRASsteroids in early settingsteroids in early settingRo4929097Ro4929097GW-843682XGW-843682Xlovastatin acidlovastatin acidPf-03084014Pf-03084014Gamma secretase inhibitorsGamma secretase inhibitorsMk-0752Mk-0752NOTCH1NOTCH1navitoclaxnavitoclaxBRD63610BRD63610triacsin Ctriacsin Ctankyrase inhibitorstankyrase inhibitorsaustocystin.Daustocystin.DSepantroniumSepantroniumNPC26NPC26PROCPROCBI-D1870BI-D1870

Models in BI-D1870

Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
MUT(APC)|AMP(APC) mix 22460902 undefined PANCAN BI-D1870 resistance in vitro
MUT(KRAS)|AMP(KRAS) mix 22460902 undefined PANCAN BI-D1870 resistance in vitro
AMP(MYC) gene 22460902 undefined PANCAN BI-D1870 sensitivity in vitro
MUT(NOTCH1) gene 22460902 undefined PANCAN BI-D1870 sensitivity in vitro
Showing 1 to 4 of 4 rows

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