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iGMDRD519

Canonical SMILES: CS(=O)(=O)N1CCN(CC1)CC2=CC3=C(S2)C(=NC(=N3)C4=C5C=NNC5=CC=C4)N6CCOCC6

InChI: InChI=1S/C23H27N7O3S2/c1-35(31,32)30-7-5-28(6-8-30)15-16-13-20-21(34-16)23(29-9-11-33-12-10-29)26-22(25-20)17-3-2-4-19-18(17)14-24-27-19/h2-4,13-14H,5-12,15H2,1H3,(H,24,27)

InChI Key: LHNIIDJUOCFXAP-UHFFFAOYSA-N

Standard Name	CHEMBL	Pubchem CID	DRUGBANK ID	Drug Status	Drug Type
GDC-0941	CHEMBL521851	17755100	DB11663	Alone	Small Molecule

Drug Class:

Amides Azoles Heterocyclic Compounds Heterocyclic Compounds, 1-Ring Heterocyclic Compounds, 2-Ring Phosphatidylinositol 3-Kinases, antagonists & inhibitors Pyrazoles Sulfones Sulfur Compounds

Drug Targets:

PI3K (class 1)

Drug Pathways:

PI3K/MTOR signaling

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
3845	KRAS	1
9757	KMT2B	1
25937	WWTR1	1
6850	SYK	1
10413	YAP1	1
1029	CDKN2A	1
4089	SMAD4	1
5290	PIK3CA	1
54206	ERRFI1	1
2113	ETS1	1
3575	IL7R	1
5291	PIK3CB	1
100862685	ERVK-19	1
5624	PROC	1

Gene in drug-gene network: Network Plot

Models in GDC-0941

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DATATYPES

CLASSFICATION

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