PIK3CB
Summary: This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:602925 Ensembl IDEnsembl:ENSG00000051382 HGNC IDHGNC:HGNC:8976 PHARMGKB IDPA33309 Map Location3q22.3 |
GO terms in PIK3CB
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
CC | IDA | GO:0005634 | nucleus |
CC | IDA | GO:0005730 | nucleolus |
CC | IBA | GO:0005737 | cytoplasm |
CC | TAS | GO:0005829 | cytosol |
CC | IBA | GO:0005886 | plasma membrane |
CC | IBA | GO:0005942 | phosphatidylinositol 3-kinase complex |
Gene expression in normal tissue: PIK3CB
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PIK3CB
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Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-109582 | Hemostasis |
reactome | R-HSA-109704 | PI3K Cascade |
reactome | R-HSA-112399 | IRS-mediated signalling |
reactome | R-HSA-114604 | GPVI-mediated activation cascade |
reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
reactome | R-HSA-1266738 | Developmental Biology |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in PIK3CB
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |