PIK3CB


Summary: This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011].

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GO terms in PIK3CB


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IDA GO:0005634 nucleus
CC IDA GO:0005730 nucleolus
CC IBA GO:0005737 cytoplasm
CC TAS GO:0005829 cytosol
CC IBA GO:0005886 plasma membrane
CC IBA GO:0005942 phosphatidylinositol 3-kinase complex
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Gene expression in normal tissue: PIK3CB

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined37PI3K/MTOR signaling3Apoptosis regulation2ERK MAPK signaling2Biosynthesis of secondary metabolites1WNT signaling1Longevity regulating pathway1Other, kinases1Th17 cell differentiation1Chromatin histone acetylation1

Pathways in PIK3CB


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Database
Pathway ID
Pathway Des.
reactome R-HSA-109582 Hemostasis
reactome R-HSA-109704 PI3K Cascade
reactome R-HSA-112399 IRS-mediated signalling
reactome R-HSA-114604 GPVI-mediated activation cascade
reactome R-HSA-1257604 PIP3 activates AKT signaling
reactome R-HSA-1266738 Developmental Biology
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD366 PI-103 1
iGMDRD329 Merck60 2
iGMDRD882 CIL41 2
iGMDRD872 BRD7137 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PIK3CB

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Level
Reference ID
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Cancer
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Clinical Response
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No matching records found

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