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PIK3CB

Summary: This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Namephosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta OMIM IDMIM:602925 Ensembl IDEnsembl:ENSG00000051382 HGNC IDHGNC:HGNC:8976 PHARMGKB IDPA33309 Map Location3q22.3

Gene Categories:

DRUGGABLE GENOME SERINE THREONINE KINASE PHOSPHATIDYLINOSITOL 3 KINASE KINASE CLINICALLY ACTIONABLE

GO terms in PIK3CB

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Term Type	Evidence Type	GO Term ID	GO Des.
CC	IDA	GO:0005634	nucleus
CC	IDA	GO:0005730	nucleolus
CC	IBA	GO:0005737	cytoplasm
CC	TAS	GO:0005829	cytosol
CC	IBA	GO:0005886	plasma membrane
CC	IBA	GO:0005942	phosphatidylinositol 3-kinase complex

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Gene expression in normal tissue: PIK3CB

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PIK3CB

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Database	Pathway ID	Pathway Des.
reactome	R-HSA-109582	Hemostasis
reactome	R-HSA-109704	PI3K Cascade
reactome	R-HSA-112399	IRS-mediated signalling
reactome	R-HSA-114604	GPVI-mediated activation cascade
reactome	R-HSA-1257604	PIP3 activates AKT signaling
reactome	R-HSA-1266738	Developmental Biology

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD366	PI-103	1
iGMDRD329	Merck60	2
iGMDRD882	CIL41	2
iGMDRD872	BRD7137	3

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PIK3CB

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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