PIK3CB


Summary: This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit betaMIM:602925Ensembl:ENSG00000051382HGNC:HGNC:8976PA333093q22.3

GO terms in PIK3CB


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005634nucleus
CCIDAGO:0005730nucleolus
CCIBAGO:0005737cytoplasm
CCTASGO:0005829cytosol
CCIBAGO:0005886plasma membrane
CCIBAGO:0005942phosphatidylinositol 3-kinase complex
CCIBAGO:0016020membrane
CCIDAGO:0030496midbody
BPTASGO:0000187activation of MAPK activity
BPIEAGO:0001935endothelial cell proliferation
BPIMPGO:0001952regulation of cell-matrix adhesion
BPIBAGO:0006468protein phosphorylation
BPIEAGO:0006874cellular calcium ion homeostasis
BPIEAGO:0006914autophagy
BPTASGO:0006935chemotaxis
BPIEAGO:0007156homophilic cell adhesion via plasma membrane adhesion molecules
BPNASGO:0007165signal transduction
BPTASGO:0007169transmembrane receptor protein tyrosine kinase signaling pathway
BPTASGO:0007186G-protein coupled receptor signaling pathway
BPTASGO:0007411axon guidance
BPTASGO:0010508positive regulation of autophagy
BPIMPGO:0010628positive regulation of gene expression
BPIBAGO:0014065phosphatidylinositol 3-kinase signaling
BPIMPGO:0014065phosphatidylinositol 3-kinase signaling
BPTASGO:0014065phosphatidylinositol 3-kinase signaling
BPIDAGO:0016310phosphorylation
BPIBAGO:0016477cell migration
BPTASGO:0016477cell migration
BPTASGO:0019221cytokine-mediated signaling pathway
BPIBAGO:0030168platelet activation
BPTASGO:0030168platelet activation
BPIMPGO:0033031positive regulation of neutrophil apoptotic process
BPIBAGO:0036092phosphatidylinositol-3-phosphate biosynthetic process
BPIEAGO:0036092phosphatidylinositol-3-phosphate biosynthetic process
BPTASGO:0038095Fc-epsilon receptor signaling pathway
BPTASGO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis
BPIEAGO:0040016embryonic cleavage
BPIBAGO:0046854phosphatidylinositol phosphorylation
BPIEAGO:0046854phosphatidylinositol phosphorylation
BPTASGO:0048010vascular endothelial growth factor receptor signaling pathway
BPIBAGO:0048015phosphatidylinositol-mediated signaling
BPTASGO:0048015phosphatidylinositol-mediated signaling
BPTASGO:0050852T cell receptor signaling pathway
BPTASGO:0050900leukocyte migration
BPTASGO:0051897positive regulation of protein kinase B signaling
BPIEAGO:0060055angiogenesis involved in wound healing
BPTASGO:0070527platelet aggregation
BPTASGO:2000369regulation of clathrin-dependent endocytosis
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIDAGO:0016301kinase activity
MFIBAGO:00163031-phosphatidylinositol-3-kinase activity
MFTASGO:00163031-phosphatidylinositol-3-kinase activity
MFTASGO:0035004phosphatidylinositol 3-kinase activity
MFIBAGO:00350051-phosphatidylinositol-4-phosphate 3-kinase activity
MFIEAGO:0043560insulin receptor substrate binding
MFTASGO:0046934phosphatidylinositol-4,5-bisphosphate 3-kinase activity
MFIBAGO:0052742phosphatidylinositol kinase activity

Gene expression in normal tissue: PIK3CB

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PIK3CB


DatabasePathway IDPathway Des.
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-109704PI3K Cascade
reactomeR-HSA-112399IRS-mediated signalling
reactomeR-HSA-114604GPVI-mediated activation cascade
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1483255PI Metabolism
reactomeR-HSA-1483257Phospholipid metabolism
reactomeR-HSA-1500931Cell-Cell communication
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-1660499Synthesis of PIPs at the plasma membrane
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-186763Downstream signal transduction
reactomeR-HSA-186797Signaling by PDGF
reactomeR-HSA-187037Signaling by NTRK1 (TRKA)
reactomeR-HSA-194138Signaling by VEGF
reactomeR-HSA-194138Signaling by VEGF
reactomeR-HSA-198203PI3K/AKT activation
reactomeR-HSA-199418Negative regulation of the PI3K/AKT network
reactomeR-HSA-202403TCR signaling
reactomeR-HSA-202424Downstream TCR signaling
reactomeR-HSA-202733Cell surface interactions at the vascular wall
reactomeR-HSA-2029480Fcgamma receptor (FCGR) dependent phagocytosis
reactomeR-HSA-2029485Role of phospholipids in phagocytosis
reactomeR-HSA-210993Tie2 Signaling
reactomeR-HSA-2172127DAP12 interactions
reactomeR-HSA-2219528PI3K/AKT Signaling in Cancer
reactomeR-HSA-2219530Constitutive Signaling by Aberrant PI3K in Cancer
reactomeR-HSA-2404192Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
reactomeR-HSA-2424491DAP12 signaling
reactomeR-HSA-2428924IGF1R signaling cascade
reactomeR-HSA-2428928IRS-related events triggered by IGF1R
reactomeR-HSA-2454202Fc epsilon receptor (FCERI) signaling
reactomeR-HSA-2730905Role of LAT2/NTAL/LAB on calcium mobilization
reactomeR-HSA-373753Nephrin family interactions
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-4420097VEGFA-VEGFR2 Pathway
reactomeR-HSA-4420097VEGFA-VEGFR2 Pathway
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-451927Interleukin-2 family signaling
reactomeR-HSA-512988Interleukin-3, Interleukin-5 and GM-CSF signaling
reactomeR-HSA-512988Interleukin-3, Interleukin-5 and GM-CSF signaling
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
reactomeR-HSA-74751Insulin receptor signalling cascade
reactomeR-HSA-74752Signaling by Insulin receptor
reactomeR-HSA-76002Platelet activation, signaling and aggregation
reactomeR-HSA-8853659RET signaling
reactomeR-HSA-9006925Intracellular signaling by second messengers
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-912526Interleukin receptor SHC signaling
reactomeR-HSA-912631Regulation of signaling by CBL
reactomeR-HSA-912631Regulation of signaling by CBL
wikipathwaysWP1403AMP-activated Protein Kinase (AMPK) Signaling
wikipathwaysWP1449Regulation of toll-like receptor signaling pathway
wikipathwaysWP1544MicroRNAs in cardiomyocyte hypertrophy
wikipathwaysWP2037Prolactin Signaling Pathway
wikipathwaysWP2261Signaling Pathways in Glioblastoma
wikipathwaysWP2593JAK-STAT
wikipathwaysWP306Focal Adhesion
wikipathwaysWP3844PI3K-AKT-mTOR signaling pathway and therapeutic opportunities
wikipathwaysWP3915Angiopoietin Like Protein 8 Regulatory Pathway
wikipathwaysWP3929Chemokine signaling pathway
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP3937Microglia Pathogen Phagocytosis Pathway
wikipathwaysWP4155Endometrial cancer
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP4205MET in type 1 papillary renal cell carcinoma
wikipathwaysWP4223Ras Signaling
wikipathwaysWP4239EMT transition in Colorectal Cancer
wikipathwaysWP481Insulin Signaling
wikipathwaysWP51Regulation of Actin Cytoskeleton
wikipathwaysWP524G13 Signaling Pathway
wikipathwaysWP710DNA Damage Response (only ATM dependent)
wikipathwaysWP75Toll-like Receptor Signaling Pathway
pidcd40_pathwayCD40/CD40L signaling
pidcxcr3pathwayCXCR3-mediated signaling events
pidcxcr4_pathwayCXCR4-mediated signaling events
piderbb1_downstream_pathwayErbB1 downstream signaling
piderbb1_internalization_pathwayInternalization of ErbB1
piderbb2erbb3pathwayErbB2/ErbB3 signaling events
piderbb4_pathwayErbB4 signaling events
pidfaspathwayFAS (CD95) signaling pathway
pidlysophospholipid_pathwayLPA receptor mediated events
pidnephrin_neph1_pathwayNephrin/Neph1 signaling in the kidney podocyte
pidpdgfrbpathwayPDGFR-beta signaling pathway
pidpi3kcipathwayClass I PI3K signaling events
pidtcptp_pathwaySignaling events mediated by TCPTP
pidtrail_pathwayTRAIL signaling pathway
netpathPathway_Alpha6Beta4IntegrinAlpha6Beta4Integrin
netpathPathway_EGFR1EGFR1
netpathPathway_IL2IL2
pharmgkbPA153627758Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics
pharmgkbPA162356267EGFR Inhibitor Pathway, Pharmacodynamics
pharmgkbPA165959584Sorafenib Pharmacodynamics
kegghsa00562Inositol phosphate metabolism - Homo sapiens (human)
kegghsa04012ErbB signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04024cAMP signaling pathway - Homo sapiens (human)
kegghsa04062Chemokine signaling pathway - Homo sapiens (human)
kegghsa04066HIF-1 signaling pathway - Homo sapiens (human)
kegghsa04068FoxO signaling pathway - Homo sapiens (human)
kegghsa04070Phosphatidylinositol signaling system - Homo sapiens (human)
kegghsa04071Sphingolipid signaling pathway - Homo sapiens (human)
kegghsa04072Phospholipase D signaling pathway - Homo sapiens (human)
kegghsa04140Autophagy - animal - Homo sapiens (human)
kegghsa04150mTOR signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04152AMPK signaling pathway - Homo sapiens (human)
kegghsa04210Apoptosis - Homo sapiens (human)
kegghsa04211Longevity regulating pathway - Homo sapiens (human)
kegghsa04213Longevity regulating pathway - multiple species - Homo sapiens (human)
kegghsa04218Cellular senescence - Homo sapiens (human)
kegghsa04360Axon guidance - Homo sapiens (human)
kegghsa04370VEGF signaling pathway - Homo sapiens (human)
kegghsa04380Osteoclast differentiation - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa04550Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
kegghsa04611Platelet activation - Homo sapiens (human)
kegghsa04620Toll-like receptor signaling pathway - Homo sapiens (human)
kegghsa04625C-type lectin receptor signaling pathway - Homo sapiens (human)
kegghsa04630Jak-STAT signaling pathway - Homo sapiens (human)
kegghsa04650Natural killer cell mediated cytotoxicity - Homo sapiens (human)
kegghsa04660T cell receptor signaling pathway - Homo sapiens (human)
kegghsa04662B cell receptor signaling pathway - Homo sapiens (human)
kegghsa04664Fc epsilon RI signaling pathway - Homo sapiens (human)
kegghsa04666Fc gamma R-mediated phagocytosis - Homo sapiens (human)
kegghsa04668TNF signaling pathway - Homo sapiens (human)
kegghsa04670Leukocyte transendothelial migration - Homo sapiens (human)
kegghsa04722Neurotrophin signaling pathway - Homo sapiens (human)
kegghsa04725Cholinergic synapse - Homo sapiens (human)
kegghsa04750Inflammatory mediator regulation of TRP channels - Homo sapiens (human)
kegghsa04810Regulation of actin cytoskeleton - Homo sapiens (human)
kegghsa04910Insulin signaling pathway - Homo sapiens (human)
kegghsa04914Progesterone-mediated oocyte maturation - Homo sapiens (human)
kegghsa04915Estrogen signaling pathway - Homo sapiens (human)
kegghsa04917Prolactin signaling pathway - Homo sapiens (human)
kegghsa04919Thyroid hormone signaling pathway - Homo sapiens (human)
kegghsa04923Regulation of lipolysis in adipocytes - Homo sapiens (human)
kegghsa04926Relaxin signaling pathway - Homo sapiens (human)
kegghsa04930Type II diabetes mellitus - Homo sapiens (human)
kegghsa04931Insulin resistance - Homo sapiens (human)
kegghsa04932Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)
kegghsa04933AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
kegghsa04960Aldosterone-regulated sodium reabsorption - Homo sapiens (human)
kegghsa04973Carbohydrate digestion and absorption - Homo sapiens (human)
kegghsa05100Bacterial invasion of epithelial cells - Homo sapiens (human)
kegghsa05142Chagas disease (American trypanosomiasis) - Homo sapiens (human)
kegghsa05146Amoebiasis - Homo sapiens (human)
kegghsa05160Hepatitis C - Homo sapiens (human)
kegghsa05161Hepatitis B - Homo sapiens (human)
kegghsa05162Measles - Homo sapiens (human)
kegghsa05164Influenza A - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegghsa05169Epstein-Barr virus infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05203Viral carcinogenesis - Homo sapiens (human)
kegghsa05205Proteoglycans in cancer - Homo sapiens (human)
kegghsa05210Colorectal cancer - Homo sapiens (human)
kegghsa05211Renal cell carcinoma - Homo sapiens (human)
kegghsa05212Pancreatic cancer - Homo sapiens (human)
kegghsa05213Endometrial cancer - Homo sapiens (human)
kegghsa05214Glioma - Homo sapiens (human)
kegghsa05215Prostate cancer - Homo sapiens (human)
kegghsa05218Melanoma - Homo sapiens (human)
kegghsa05220Chronic myeloid leukemia - Homo sapiens (human)
kegghsa05221Acute myeloid leukemia - Homo sapiens (human)
kegghsa05222Small cell lung cancer - Homo sapiens (human)
kegghsa05223Non-small cell lung cancer - Homo sapiens (human)
kegghsa05224Breast cancer - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
kegghsa05226Gastric cancer - Homo sapiens (human)
kegghsa05230Central carbon metabolism in cancer - Homo sapiens (human)
kegghsa05231Choline metabolism in cancer - Homo sapiens (human)
kegghsa05418Fluid shear stress and atherosclerosis - Homo sapiens (human)
humancycPWY-63523-phosphoinositide biosynthesis
humancycPWY-6371superpathway of inositol phosphate compounds

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD366PI-1031
iGMDRD329Merck602
iGMDRD882CIL412
iGMDRD872BRD71373
iGMDRD871BRD63684
iGMDRD353PD03259011
iGMDRD82Quiflapon4
iGMDRD402AKT Inhibitor VIII4
iGMDRD5Tyrphostin AG 14782
iGMDRD202Curcumin6
iGMDRD137Indisulam2
iGMDRD271Brefeldin A2
iGMDRD158NSC1415404
iGMDRD77Itraconazole1
iGMDRD213SMR0000686502
iGMDRD415LE-1352
iGMDRD434BMS-5369242
iGMDRD221Tamoxifen2
iGMDRD289Parthenolide2
iGMDRD219Bax channel blocker2
iGMDRD314Tanespimycin3
iGMDRD499PDMP1
iGMDRD341Triacsin c3
iGMDRD132(-)-gallocatechin-3-O-gallate3
iGMDRD177Teniposide2
iGMDRD584VER 1550082
iGMDRD307Manumycin A4
iGMDRD299ICL 6702
iGMDRD562Navitoclax7
iGMDRD780PP-305
iGMDRD506Fedratinib4
iGMDRD577BIX012947
iGMDRD399Selumetinib7
iGMDRD188Piperlongumine3
iGMDRD524ISX-94
iGMDRD23Gossypol4
iGMDRD60Quinoclamine2
iGMDRD952mTORC1/2 inhibitor4
iGMDRD474Avrainvillamide2
iGMDRD138PX 122
iGMDRD270Ciclosporin3
iGMDRD187BRD98762
iGMDRD318PAC-15
iGMDRD885Compound 1105
iGMDRD983PI3K pathway inhibitor3
iGMDRD519GDC-09411
iGMDRD394BX-7952
iGMDRD679Bistramide A5
iGMDRD772BRD47704
iGMDRD387CHIR-990212
iGMDRD889Compound 7d-cis5
iGMDRD126Tipifarnib2
iGMDRD781Sirolimus3
iGMDRD427ABT7371

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PIK3CB

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