IL7R

Summary: The protein encoded by this gene is a receptor for interleukin 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukins 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in V(D)J recombination during lymphocyte development. Defects in this gene may be associated with severe combined immunodeficiency (SCID). Alternatively spliced transcript variants have been found. [provided by RefSeq, Dec 2015].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameinterleukin 7 receptor
OMIM IDMIM:146661
Ensembl IDEnsembl:ENSG00000168685
HGNC IDHGNC:HGNC:6024
PHARMGKB IDPA29840
Map Location5p13.2

GO terms in IL7R


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Term Type
Evidence Type
GO Term ID
GO Des.
MF TAS GO:0003823 antigen binding
MF IDA GO:0004896 cytokine receptor activity
MF TAS GO:0004917 interleukin-7 receptor activity
MF IPI GO:0005515 protein binding
CC IEA GO:0005576 extracellular region
CC TAS GO:0005886 plasma membrane
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Gene expression in normal tissue: IL7R

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 4BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: Acute Lymphoid Leukemia (ALL) model num: 12

Gene-drug pathway distribution

undefined2Protein stability and degradation1WNT signaling1PI3K/MTOR signaling1Other, kinases1JNK and p38 signaling1

Pathways in IL7R


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1266695 Interleukin-7 signaling
reactome R-HSA-1266695 Interleukin-7 signaling
reactome R-HSA-1280215 Cytokine Signaling in Immune system
reactome R-HSA-1280215 Cytokine Signaling in Immune system
reactome R-HSA-168256 Immune System
reactome R-HSA-168256 Immune System
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD454 JNK Inhibitor VIII 1
iGMDRD574 Ruxolitinib 8
iGMDRD519 GDC-0941 1
iGMDRD949 mTOR inhibitor 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IL7R

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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