IL7R
Summary: The protein encoded by this gene is a receptor for interleukin 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukins 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in V(D)J recombination during lymphocyte development. Defects in this gene may be associated with severe combined immunodeficiency (SCID). Alternatively spliced transcript variants have been found. [provided by RefSeq, Dec 2015].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:146661 Ensembl IDEnsembl:ENSG00000168685 HGNC IDHGNC:HGNC:6024 PHARMGKB IDPA29840 Map Location5p13.2 |
GO terms in IL7R
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | TAS | GO:0003823 | antigen binding |
MF | IDA | GO:0004896 | cytokine receptor activity |
MF | TAS | GO:0004917 | interleukin-7 receptor activity |
MF | IPI | GO:0005515 | protein binding |
CC | IEA | GO:0005576 | extracellular region |
CC | TAS | GO:0005886 | plasma membrane |
Gene expression in normal tissue: IL7R
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IL7R
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Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-1266695 | Interleukin-7 signaling |
reactome | R-HSA-1266695 | Interleukin-7 signaling |
reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
reactome | R-HSA-168256 | Immune System |
reactome | R-HSA-168256 | Immune System |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in IL7R
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |