Summary: The protein encoded by this gene is a receptor for interleukin 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukins 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in V(D)J recombination during lymphocyte development. Defects in this gene may be associated with severe combined immunodeficiency (SCID). Alternatively spliced transcript variants have been found. [provided by RefSeq, Dec 2015].

interleukin 7 receptorMIM:146661Ensembl:ENSG00000168685HGNC:HGNC:6024PA298405p13.2

GO terms in IL7R

Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0003823antigen binding
MFIDAGO:0004896cytokine receptor activity
MFTASGO:0004917interleukin-7 receptor activity
MFIPIGO:0005515protein binding
CCIEAGO:0005576extracellular region
CCTASGO:0005886plasma membrane
CCIEAGO:0009897external side of plasma membrane
CCIEAGO:0016021integral component of membrane
CCTASGO:0030665clathrin-coated vesicle membrane
BPTASGO:0000018regulation of DNA recombination
BPIEAGO:0000902cell morphogenesis
BPIEAGO:0001915negative regulation of T cell mediated cytotoxicity
BPIEAGO:0002377immunoglobulin production
BPTASGO:0006955immune response
BPTASGO:0007165signal transduction
BPTASGO:0007166cell surface receptor signaling pathway
BPIDAGO:0008284positive regulation of cell proliferation
BPIEAGO:0008361regulation of cell size
BPIEAGO:0010628positive regulation of gene expression
BPIEAGO:0030217T cell differentiation
BPIEAGO:0033089positive regulation of T cell differentiation in thymus
BPTASGO:0038111interleukin-7-mediated signaling pathway
BPIEAGO:0042100B cell proliferation
BPIEAGO:0048535lymph node development
BPIEAGO:0048872homeostasis of number of cells
BPTASGO:0061024membrane organization
BPIEAGO:0070233negative regulation of T cell apoptotic process
BPIDAGO:1904894positive regulation of STAT cascade

Gene expression in normal tissue: IL7R

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in IL7R

DatabasePathway IDPathway Des.
reactomeR-HSA-1266695Interleukin-7 signaling
reactomeR-HSA-1266695Interleukin-7 signaling
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-168256Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-8856825Cargo recognition for clathrin-mediated endocytosis
reactomeR-HSA-8856828Clathrin-mediated endocytosis
wikipathwaysWP205IL-7 Signaling Pathway
wikipathwaysWP2203Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway
wikipathwaysWP2864Apoptosis-related network due to altered Notch3 in ovarian cancer
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP4172PI3K-Akt Signaling Pathway
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04068FoxO signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04630Jak-STAT signaling pathway - Homo sapiens (human)
kegghsa04640Hematopoietic cell lineage - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05340Primary immunodeficiency - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD454JNK Inhibitor VIII1
iGMDRD949mTOR inhibitor3
iGMDRD541SNX-2112 (PF-04928473)1
iGMDRD950mTOR inhibitor (in SH2B3 deleted)1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IL7R