ETS1
Summary: This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:164720 Ensembl IDEnsembl:ENSG00000134954 HGNC IDHGNC:HGNC:3488 PHARMGKB IDPA27902 Map Location11q24.3 |
GO terms in ETS1
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IDA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
MF | IBA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
MF | IDA | GO:0000982 | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
Gene expression in normal tissue: ETS1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ETS1
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Database | Pathway ID | Pathway Des. |
---|---|---|
wikipathways | WP2064 | Neural Crest Differentiation |
wikipathways | WP23 | B Cell Receptor Signaling Pathway |
wikipathways | WP2864 | Apoptosis-related network due to altered Notch3 in ovarian cancer |
wikipathways | WP366 | TGF-beta Signaling Pathway |
wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
wikipathways | WP4205 | MET in type 1 papillary renal cell carcinoma |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in ETS1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |