ETS1


Summary: This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011].

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GO terms in ETS1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IDA GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding
MF IBA GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF ISA GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF ISM GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF NAS GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF IDA GO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
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Gene expression in normal tissue: ETS1

Gene-model tissue-cancer distribution: Bubble Plot

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Gene-drug pathway distribution

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Pathways in ETS1


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Database
Pathway ID
Pathway Des.
wikipathways WP2064 Neural Crest Differentiation
wikipathways WP23 B Cell Receptor Signaling Pathway
wikipathways WP2864 Apoptosis-related network due to altered Notch3 in ovarian cancer
wikipathways WP366 TGF-beta Signaling Pathway
wikipathways WP3888 VEGFA-VEGFR2 Signaling Pathway
wikipathways WP4205 MET in type 1 papillary renal cell carcinoma
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD125 BIRB-796 1
iGMDRD50 Cytarabine 1
iGMDRD564 GSK-650394 1
iGMDRD382 CEP-701 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ETS1

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Level
Reference ID
Tissue
Cancer
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