ETS1
Summary: This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ETS proto-oncogene 1, transcription factor | MIM:164720 | Ensembl:ENSG00000134954 | HGNC:HGNC:3488 | PA27902 | 11q24.3 |
GO terms in ETS1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IBA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IDA | GO:0000982 | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IC | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | ISS | GO:0003677 | DNA binding |
| MF | IDA | GO:0003700 | DNA-binding transcription factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | NAS | GO:0008134 | transcription factor binding |
| MF | IEA | GO:0035035 | histone acetyltransferase binding |
| MF | IPI | GO:0042802 | identical protein binding |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005667 | transcription factor complex |
| CC | IEA | GO:0005737 | cytoplasm |
| BP | IEA | GO:0001666 | response to hypoxia |
| BP | IBA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0006955 | immune response |
| BP | IEA | GO:0007565 | female pregnancy |
| BP | IEA | GO:0008284 | positive regulation of cell proliferation |
| BP | TAS | GO:0008285 | negative regulation of cell proliferation |
| BP | IEA | GO:0009612 | response to mechanical stimulus |
| BP | IMP | GO:0010595 | positive regulation of endothelial cell migration |
| BP | IMP | GO:0010628 | positive regulation of gene expression |
| BP | IEA | GO:0010715 | regulation of extracellular matrix disassembly |
| BP | IEA | GO:0021854 | hypothalamus development |
| BP | IEA | GO:0021983 | pituitary gland development |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IDA | GO:0030578 | PML body organization |
| BP | IEA | GO:0032355 | response to estradiol |
| BP | IEA | GO:0034616 | response to laminar fluid shear stress |
| BP | IMP | GO:0043536 | positive regulation of blood vessel endothelial cell migration |
| BP | IEA | GO:0044849 | estrous cycle |
| BP | IDA | GO:0045648 | positive regulation of erythrocyte differentiation |
| BP | IMP | GO:0045765 | regulation of angiogenesis |
| BP | IMP | GO:0045766 | positive regulation of angiogenesis |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0048870 | cell motility |
| BP | IEA | GO:0050728 | negative regulation of inflammatory response |
| BP | IDA | GO:0050729 | positive regulation of inflammatory response |
| BP | IMP | GO:0051272 | positive regulation of cellular component movement |
| BP | IEA | GO:0060055 | angiogenesis involved in wound healing |
| BP | IDA | GO:0061614 | pri-miRNA transcription by RNA polymerase II |
| BP | IEA | GO:0070301 | cellular response to hydrogen peroxide |
| BP | IEA | GO:0070555 | response to interleukin-1 |
| BP | IMP | GO:1904996 | positive regulation of leukocyte adhesion to vascular endothelial cell |
Gene expression in normal tissue: ETS1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ETS1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2064 | Neural Crest Differentiation |
| wikipathways | WP23 | B Cell Receptor Signaling Pathway |
| wikipathways | WP2864 | Apoptosis-related network due to altered Notch3 in ovarian cancer |
| wikipathways | WP366 | TGF-beta Signaling Pathway |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP4205 | MET in type 1 papillary renal cell carcinoma |
| wikipathways | WP4223 | Ras Signaling |
| pid | angiopoietinreceptor_pathway | Angiopoietin receptor Tie2-mediated signaling |
| pid | ap1_pathway | AP-1 transcription factor network |
| pid | bcr_5pathway | BCR signaling pathway |
| pid | cmyb_pathway | C-MYB transcription factor network |
| pid | fak_pathway | Signaling events mediated by focal adhesion kinase |
| pid | hif1_tfpathway | HIF-1-alpha transcription factor network |
| pid | hif2pathway | HIF-2-alpha transcription factor network |
| pid | il4_2pathway | IL4-mediated signaling events |
| pid | met_pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05211 | Renal cell carcinoma - Homo sapiens (human) |
| pharmgkb | PA165980050 | Vemurafenib Pathway, Pharmacodynamics |
| pharmgkb | PA165980050 | update your name in edit mode |
| netpath | Pathway_IL2 | IL2 |
| netpath | Pathway_IL4 | IL4 |
| netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
| biocarta | etspathway | mets affect on macrophage differentiation |
| biocarta | keratinocytepathway | keratinocyte differentiation |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2559583 | Cellular Senescence |
| reactome | R-HSA-2559585 | Oncogene Induced Senescence |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD125 | BIRB-796 | 1 |
| iGMDRD50 | Cytarabine | 1 |
| iGMDRD564 | GSK-650394 | 1 |
| iGMDRD382 | CEP-701 | 1 |
| iGMDRD39 | Pyrimethamine | 1 |
| iGMDRD481 | Dactolisib | 1 |
| iGMDRD551 | Ponatinib | 1 |
| iGMDRD124 | Canertinib | 1 |
| iGMDRD158 | NSC141540 | 1 |
| iGMDRD467 | Motesanib | 1 |
| iGMDRD42 | Vorinostat | 1 |
| iGMDRD421 | AZD7762 | 1 |
| iGMDRD658 | CHEMBL1673039 | 1 |
| iGMDRD119 | Temsirolimus | 1 |
| iGMDRD549 | Ibrutinib (PCI-32765) | 1 |
| iGMDRD63 | Camptothecin | 1 |
| iGMDRD397 | Pazopanib | 1 |
| iGMDRD354 | Midostaurin | 1 |
| iGMDRD12 | Bicalutamide | 1 |
| iGMDRD519 | GDC-0941 | 1 |
| iGMDRD253 | Vincaleukoblastine | 1 |
| iGMDRD284 | Palbociclib | 1 |
| iGMDRD647 | StemRegenin 1 | 1 |
| iGMDRD318 | PAC-1 | 2 |
| iGMDRD480 | KU0060648 | 1 |
| iGMDRD700 | AUY922 | 1 |
| iGMDRD493 | GSK269962A | 1 |
| iGMDRD225 | AC1MD3YP | 1 |
| iGMDRD454 | JNK Inhibitor VIII | 1 |
| iGMDRD371 | THR1 Inhibitor | 1 |
| iGMDRD133 | Lapatinib | 1 |
| iGMDRD887 | Compound 23 citrate | 1 |
| iGMDRD185 | DMOG | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ETS1
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.