ETS1

Summary: This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameETS proto-oncogene 1, transcription factor
OMIM IDMIM:164720
Ensembl IDEnsembl:ENSG00000134954
HGNC IDHGNC:HGNC:3488
PHARMGKB IDPA27902
Map Location11q24.3

GO terms in ETS1


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
MF IDA GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding
MF IBA GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF ISA GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF ISM GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF NAS GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF IDA GO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
Showing 1 to 6 of 51 rows rows per page

Gene expression in normal tissue: ETS1

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 32SKItissue: SKI cancer: SKIN model num: 0SKINtissue: SKIN cancer: undefined model num: 2

Gene-drug pathway distribution

undefined10PI3K/MTOR signaling3RTK signaling3JNK and p38 signaling2Cell cycle2Other, kinases2DNA replication2Metabolism1Cytoskeleton1Breast cancer1

Pathways in ETS1


Loading, please wait...
Database
Pathway ID
Pathway Des.
wikipathways WP2064 Neural Crest Differentiation
wikipathways WP23 B Cell Receptor Signaling Pathway
wikipathways WP2864 Apoptosis-related network due to altered Notch3 in ovarian cancer
wikipathways WP366 TGF-beta Signaling Pathway
wikipathways WP3888 VEGFA-VEGFR2 Signaling Pathway
wikipathways WP4205 MET in type 1 papillary renal cell carcinoma
Showing 1 to 6 of 32 rows rows per page

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD125 BIRB-796 1
iGMDRD50 Cytarabine 1
iGMDRD564 GSK-650394 1
iGMDRD382 CEP-701 1
Showing 1 to 4 of 33 rows rows per page

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ETS1

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​

SITE
DATATYPES
CLASSFICATION
Map

Copyright © 2018 Modellab | All Rights Reserved

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.