iGMDRD230

Canonical SMILES: COC1=CC=C(C=C1)C2(CCOCC2)CNC(=O)C3=CC=C(C=C3)NC(=O)C4=CC=CO4

InChI: InChI=1S/C25H26N2O5/c1-30-21-10-6-19(7-11-21)25(12-15-31-16-13-25)17-26-23(28)18-4-8-20(9-5-18)27-24(29)22-3-2-14-32-22/h2-11,14H,12-13,15-17H2,1H3,(H,26,28)(H,27,29)

InChI Key: ZJZWZIXSGNFWQQ-UHFFFAOYSA-N

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Standard Name
CHEMBL
Pubchem CID
Drug Status
Drug Type
Standard NameJW 55
CHEMBLCHEMBL3753077
Pubchem CID2946600
Drug StatusAlone
Drug TypeSmall Molecule

Drug-model tissue-cancer distribution: Bubble Plot

BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: Colorectal Cancer model num: 1

Drug-gene pathway enrichments

1reactome: Post-translational protein modification1reactome: Post-translational protein phosphorylation1reactome: Metabolism of proteins1reactome: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)1reactome: Cell surface interactions at the vascular wall1biocarta: extrinsic prothrombin activation pathway1biocarta: inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages1biocarta: tgf beta signaling pathway1biocarta: wnt signaling pathway1biocarta: multi-step regulation of transcription by pitx2

Drug-gene GO enrichments

3MF: serine-type endopeptidase activity2CC: extracellular region2BP: negative regulation of blood coagulation1BP: negative regulation of coagulation1BP: positive regulation of establishment of endothelial barrier1CC: extracellular space1CC: Golgi lumen1CC: Golgi apparatus1CC: endoplasmic reticulum lumen1CC: endoplasmic reticulum

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
5624 PROC 1
Showing 1 to 1 of 1 rows

Gene in drug-gene network: Network Plot

Models in JW 55

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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