PTPRN
Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein tyrosine phosphatase, receptor type N | MIM:601773 | Ensembl:ENSG00000054356 | HGNC:HGNC:9676 | PA34021 | 2q35 |
GO terms in PTPRN
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISS | GO:0004725 | protein tyrosine phosphatase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008134 | transcription factor binding |
| MF | IPI | GO:0030507 | spectrin binding |
| MF | IDA | GO:0044389 | ubiquitin-like protein ligase binding |
| MF | IEA | GO:0051020 | GTPase binding |
| CC | IDA | GO:0005634 | nucleus |
| CC | ISS | GO:0005768 | endosome |
| CC | ISS | GO:0005794 | Golgi apparatus |
| CC | ISS | GO:0005886 | plasma membrane |
| CC | ISS | GO:0008021 | synaptic vesicle |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0030054 | cell junction |
| CC | ISS | GO:0030141 | secretory granule |
| CC | IEA | GO:0030658 | transport vesicle membrane |
| CC | ISS | GO:0043025 | neuronal cell body |
| CC | IEA | GO:0043204 | perikaryon |
| CC | ISS | GO:0043679 | axon terminus |
| CC | ISS | GO:0045202 | synapse |
| BP | IDA | GO:0000302 | response to reactive oxygen species |
| BP | ISS | GO:0001553 | luteinization |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IGI | GO:0030073 | insulin secretion |
| BP | IEA | GO:0032868 | response to insulin |
| BP | ISS | GO:0035773 | insulin secretion involved in cellular response to glucose stimulus |
| BP | IEA | GO:0043627 | response to estrogen |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0051591 | response to cAMP |
| BP | IDA | GO:1904692 | positive regulation of type B pancreatic cell proliferation |
| BP | IGI | GO:1990502 | dense core granule maturation |
Gene expression in normal tissue: PTPRN
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PTPRN
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04940 | Type I diabetes mellitus - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PTPRN
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