PTPRN


Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

GO terms in PTPRN


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Term Type
Evidence Type
GO Term ID
GO Des.
MF ISS GO:0004725 protein tyrosine phosphatase activity
MF IPI GO:0005515 protein binding
MF IDA GO:0008134 transcription factor binding
MF IPI GO:0030507 spectrin binding
MF IDA GO:0044389 ubiquitin-like protein ligase binding
MF IEA GO:0051020 GTPase binding
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Gene expression in normal tissue: PTPRN

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Cell cycle1ERK MAPK signaling1

Pathways in PTPRN


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Database
Pathway ID
Pathway Des.
kegg hsa04940 Type I diabetes mellitus - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 1
iGMDRD284 Palbociclib 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PTPRN

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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