PTPRN
Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:601773 Ensembl IDEnsembl:ENSG00000054356 HGNC IDHGNC:HGNC:9676 PHARMGKB IDPA34021 Map Location2q35 |
GO terms in PTPRN
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | ISS | GO:0004725 | protein tyrosine phosphatase activity |
MF | IPI | GO:0005515 | protein binding |
MF | IDA | GO:0008134 | transcription factor binding |
MF | IPI | GO:0030507 | spectrin binding |
MF | IDA | GO:0044389 | ubiquitin-like protein ligase binding |
MF | IEA | GO:0051020 | GTPase binding |
Gene expression in normal tissue: PTPRN
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PTPRN
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Database | Pathway ID | Pathway Des. |
---|---|---|
kegg | hsa04940 | Type I diabetes mellitus - Homo sapiens (human) |
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Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in PTPRN
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |