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REEP1

Summary: This gene encodes a mitochondrial protein that functions to enhance the cell surface expression of odorant receptors. Mutations in this gene cause spastic paraplegia autosomal dominant type 31, a neurodegenerative disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
receptor accessory protein 1	MIM:609139	Ensembl:ENSG00000068615	HGNC:HGNC:25786	PA134906680	2p11.2

GO terms in REEP1

Term Type	Evidence Type	GO Term ID	GO Des.
BP	IEA	GO:0032386	regulation of intracellular transport
BP	IDA	GO:0051205	protein insertion into membrane
BP	IMP	GO:0071786	endoplasmic reticulum tubular network organization
CC	IDA	GO:0005737	cytoplasm
CC	IDA	GO:0005783	endoplasmic reticulum
CC	IEA	GO:0005789	endoplasmic reticulum membrane
CC	IDA	GO:0016020	membrane
CC	IEA	GO:0016021	integral component of membrane
CC	IEA	GO:0031966	mitochondrial membrane
CC	ISS	GO:0071782	endoplasmic reticulum tubular network
MF	IPI	GO:0005515	protein binding
MF	IDA	GO:0008017	microtubule binding
MF	IMP	GO:0031849	olfactory receptor binding

Gene expression in normal tissue: REEP1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in REEP1

Database	Pathway ID	Pathway Des.
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-372790	Signaling by GPCR
reactome	R-HSA-381753	Olfactory Signaling Pathway
reactome	R-HSA-388396	GPCR downstream signalling
reactome	R-HSA-418555	G alpha (s) signalling events

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD284	Palbociclib	1
iGMDRD353	PD0325901	2
iGMDRD309	17AAG	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in REEP1

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DATATYPES

CLASSFICATION

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