HOXA7


Summary: In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. This gene is highly similar to the antennapedia (Antp) gene of Drosophila. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
homeobox A7MIM:142950Ensembl:ENSG00000122592HGNC:HGNC:5108PA293857p15.2

GO terms in HOXA7


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFIBAGO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIBAGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIDAGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIBAGO:0003705transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
MFIPIGO:0008134transcription factor binding
MFIDAGO:0043565sequence-specific DNA binding
CCIBAGO:0005634nucleus
CCICGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCIDAGO:0031965nuclear membrane
BPIDAGO:0000122negative regulation of transcription by RNA polymerase II
BPIEPGO:0001525angiogenesis
BPIDAGO:0001953negative regulation of cell-matrix adhesion
BPIDAGO:0002686negative regulation of leukocyte migration
BPIEAGO:0006366transcription by RNA polymerase II
BPIBAGO:0009952anterior/posterior pattern specification
BPIEAGO:0009952anterior/posterior pattern specification
BPIDAGO:0045617negative regulation of keratinocyte differentiation
BPIDAGO:0045656negative regulation of monocyte differentiation
BPIDAGO:0045892negative regulation of transcription, DNA-templated
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0048704embryonic skeletal system morphogenesis
BPIEAGO:0048863stem cell differentiation

Gene expression in normal tissue: HOXA7

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in HOXA7


DatabasePathway IDPathway Des.
biocartakeratinocytepathwaykeratinocyte differentiation
wikipathwaysWP2006miR-targeted genes in squamous cell - TarBase

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD284Palbociclib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HOXA7

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