HOXA7
Summary: In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. This gene is highly similar to the antennapedia (Antp) gene of Drosophila. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| homeobox A7 | MIM:142950 | Ensembl:ENSG00000122592 | HGNC:HGNC:5108 | PA29385 | 7p15.2 |
Gene Categories:
TRANSCRIPTION FACTOR BINDINGGO terms in HOXA7
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IBA | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IBA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IDA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IBA | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding |
| MF | IPI | GO:0008134 | transcription factor binding |
| MF | IDA | GO:0043565 | sequence-specific DNA binding |
| CC | IBA | GO:0005634 | nucleus |
| CC | IC | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0031965 | nuclear membrane |
| BP | IDA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEP | GO:0001525 | angiogenesis |
| BP | IDA | GO:0001953 | negative regulation of cell-matrix adhesion |
| BP | IDA | GO:0002686 | negative regulation of leukocyte migration |
| BP | IEA | GO:0006366 | transcription by RNA polymerase II |
| BP | IBA | GO:0009952 | anterior/posterior pattern specification |
| BP | IEA | GO:0009952 | anterior/posterior pattern specification |
| BP | IDA | GO:0045617 | negative regulation of keratinocyte differentiation |
| BP | IDA | GO:0045656 | negative regulation of monocyte differentiation |
| BP | IDA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0048704 | embryonic skeletal system morphogenesis |
| BP | IEA | GO:0048863 | stem cell differentiation |
Gene expression in normal tissue: HOXA7
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HOXA7
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | keratinocytepathway | keratinocyte differentiation |
| wikipathways | WP2006 | miR-targeted genes in squamous cell - TarBase |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HOXA7
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