MRPS27
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that may be a functional partner of the death associated protein 3 (DAP3). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2013].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:611989 Ensembl IDEnsembl:ENSG00000113048 HGNC IDHGNC:HGNC:14512 PHARMGKB IDPA31015 Map Location5q13.2 | |||||
GO terms in MRPS27
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0000049 | tRNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0019843 | rRNA binding |
| MF | IDA | GO:0097177 | mitochondrial ribosome binding |
| BP | IMP | GO:0008283 | cell proliferation |
| BP | TAS | GO:0070125 | mitochondrial translational elongation |
Gene expression in normal tissue: MRPS27
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MRPS27
Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5368286 | Mitochondrial translation initiation |
| reactome | R-HSA-5368287 | Mitochondrial translation |
| reactome | R-HSA-5368287 | Mitochondrial translation |
| reactome | R-HSA-5389840 | Mitochondrial translation elongation |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MRPS27
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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