CCND2


Summary: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3). [provided by RefSeq, Sep 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
cyclin D2MIM:123833Ensembl:ENSG00000118971HGNC:HGNC:1583PA2615012p13.32

GO terms in CCND2


Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity
BPIBAGO:0000278mitotic cell cycle
BPIDAGO:0001934positive regulation of protein phosphorylation
BPIEAGO:0007049cell cycle
BPIBAGO:0007088regulation of mitotic nuclear division
BPIEAGO:0007616long-term memory
BPIBAGO:0008284positive regulation of cell proliferation
BPIMPGO:0008284positive regulation of cell proliferation
BPIEAGO:0008344adult locomotory behavior
BPIMPGO:0043066negative regulation of apoptotic process
BPIDAGO:0045737positive regulation of cyclin-dependent protein serine/threonine kinase activity
BPIBAGO:0045787positive regulation of cell cycle
BPIEAGO:0051301cell division
BPIEAGO:0071481cellular response to X-ray
BPIBAGO:1900087positive regulation of G1/S transition of mitotic cell cycle
BPIMPGO:1900087positive regulation of G1/S transition of mitotic cell cycle
CCIBAGO:0000307cyclin-dependent protein kinase holoenzyme complex
CCIDAGO:0000307cyclin-dependent protein kinase holoenzyme complex
CCIDAGO:0000785chromatin
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCIDAGO:0005730nucleolus
CCIBAGO:0005737cytoplasm
CCIDAGO:0005829cytosol
CCIDAGO:0031965nuclear membrane
CCIEAGO:0097129cyclin D2-CDK4 complex
MFIBAGO:0004672protein kinase activity
MFIPIGO:0005515protein binding
MFIBAGO:0016538cyclin-dependent protein serine/threonine kinase regulator activity
MFIBAGO:0019901protein kinase binding
MFIPIGO:0019901protein kinase binding

Gene expression in normal tissue: CCND2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CCND2


DatabasePathway IDPathway Des.
biocartacellcyclepathwaycyclins and cell cycle regulation
biocartail2rbpathwayil-2 receptor beta chain in t cell activation
biocartapitx2pathwaymulti-step regulation of transcription by pitx2
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-453279Mitotic G1-G1/S phases
reactomeR-HSA-69231Cyclin D associated events in G1
reactomeR-HSA-69236G1 Phase
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8878171Transcriptional regulation by RUNX1
reactomeR-HSA-8934593Regulation of RUNX1 Expression and Activity
wikipathwaysWP1530miRNA Regulation of DNA Damage Response
wikipathwaysWP179Cell Cycle
wikipathwaysWP1991SRF and miRs in Smooth Muscle Differentiation and Proliferation
wikipathwaysWP2261Signaling Pathways in Glioblastoma
wikipathwaysWP306Focal Adhesion
wikipathwaysWP34Ovarian Infertility Genes
wikipathwaysWP399Wnt Signaling Pathway and Pluripotency
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP4249Hedgehog Signaling Pathway
wikipathwaysWP428Wnt Signaling Pathway
wikipathwaysWP45G1 to S cell cycle control
wikipathwaysWP49IL-2 Signaling Pathway
wikipathwaysWP707DNA Damage Response
wikipathwaysWP710DNA Damage Response (only ATM dependent)
pidbetacatenin_nuc_pathwayRegulation of nuclear beta catenin signaling and target gene transcription
pidil2_stat5pathwayIL2 signaling events mediated by STAT5
pidmyc_activpathwayValidated targets of C-MYC transcriptional activation
pidrb_1pathwayRegulation of retinoblastoma protein
kegghsa04068FoxO signaling pathway - Homo sapiens (human)
kegghsa04110Cell cycle - Homo sapiens (human)
kegghsa04115p53 signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04218Cellular senescence - Homo sapiens (human)
kegghsa04310Wnt signaling pathway - Homo sapiens (human)
kegghsa04340Hedgehog signaling pathway - Homo sapiens (human)
kegghsa04390Hippo signaling pathway - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa04630Jak-STAT signaling pathway - Homo sapiens (human)
kegghsa04917Prolactin signaling pathway - Homo sapiens (human)
kegghsa05162Measles - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05202Transcriptional misregulation in cancer - Homo sapiens (human)
kegghsa05203Viral carcinogenesis - Homo sapiens (human)
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD292NSC878771
iGMDRD85Ursolic acid2
iGMDRD351GW843682X1
iGMDRD237ABT-7511
iGMDRD945ML2143
iGMDRD84Lovastatin acid4
iGMDRD48Dexamethasone2
iGMDRD330BRD41321
iGMDRD307Manumycin A5
iGMDRD584VER 1550083
iGMDRD248BRD43542
iGMDRD560MK-22064
iGMDRD286Nsc 6328393
iGMDRD367Ro 28-16751
iGMDRD882CIL415
iGMDRD329Merck604
iGMDRD662JQ-11
iGMDRD209BRD63403
iGMDRD246NPC263
iGMDRD82Quiflapon2
iGMDRD158NSC1415401
iGMDRD202Curcumin3
iGMDRD220fumonisin B12
iGMDRD289Parthenolide3
iGMDRD105Triptolide1
iGMDRD6AM-5801
iGMDRD434BMS-5369242
iGMDRD481Dactolisib1
iGMDRD267Oligomycin A1
iGMDRD231Importazole1
iGMDRD446LY 21832402
iGMDRD193Fqi11
iGMDRD280CYTOCHALASIN B1
iGMDRD126Tipifarnib2
iGMDRD210AC556493
iGMDRD554CHEMBL14341371
iGMDRD387CHIR-990211
iGMDRD599Salermide2
iGMDRD889Compound 7d-cis6
iGMDRD654SL 0101-11
iGMDRD425ERASTIN1
iGMDRD427ABT7372
iGMDRD494Neopeltolide2
iGMDRD100Zebularine2
iGMDRD188Piperlongumine4
iGMDRD577BIX012941
iGMDRD888Compound 442
iGMDRD562Navitoclax2
iGMDRD183CDK4/6 inhibitor2
iGMDRD268Cerulenin2
iGMDRD23Gossypol2
iGMDRD524ISX-96
iGMDRD255SB2250026
iGMDRD284Palbociclib1
iGMDRD478ABT-8881

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CCND2

​​​​