SEARCH

HOME / SEARCH / CCND2

CCND2

Summary: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3). [provided by RefSeq, Sep 2014].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
cyclin D2	MIM:123833	Ensembl:ENSG00000118971	HGNC:HGNC:1583	PA26150	12p13.32

Gene Categories:

TUMOR SUPPRESSOR SERINE THREONINE KINASE KINASE CLINICALLY ACTIONABLE DRUGGABLE GENOME

GO terms in CCND2

Term Type	Evidence Type	GO Term ID	GO Des.
BP	IBA	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
BP	IBA	GO:0000278	mitotic cell cycle
BP	IDA	GO:0001934	positive regulation of protein phosphorylation
BP	IEA	GO:0007049	cell cycle
BP	IBA	GO:0007088	regulation of mitotic nuclear division
BP	IEA	GO:0007616	long-term memory
BP	IBA	GO:0008284	positive regulation of cell proliferation
BP	IMP	GO:0008284	positive regulation of cell proliferation
BP	IEA	GO:0008344	adult locomotory behavior
BP	IMP	GO:0043066	negative regulation of apoptotic process
BP	IDA	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity
BP	IBA	GO:0045787	positive regulation of cell cycle
BP	IEA	GO:0051301	cell division
BP	IEA	GO:0071481	cellular response to X-ray
BP	IBA	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle
BP	IMP	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle
CC	IBA	GO:0000307	cyclin-dependent protein kinase holoenzyme complex
CC	IDA	GO:0000307	cyclin-dependent protein kinase holoenzyme complex
CC	IDA	GO:0000785	chromatin
CC	IBA	GO:0005634	nucleus
CC	IDA	GO:0005634	nucleus
CC	IDA	GO:0005654	nucleoplasm
CC	IDA	GO:0005730	nucleolus
CC	IBA	GO:0005737	cytoplasm
CC	IDA	GO:0005829	cytosol
CC	IDA	GO:0031965	nuclear membrane
CC	IEA	GO:0097129	cyclin D2-CDK4 complex
MF	IBA	GO:0004672	protein kinase activity
MF	IPI	GO:0005515	protein binding
MF	IBA	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity
MF	IBA	GO:0019901	protein kinase binding
MF	IPI	GO:0019901	protein kinase binding

Gene expression in normal tissue: CCND2

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CCND2

Database	Pathway ID	Pathway Des.
biocarta	cellcyclepathway	cyclins and cell cycle regulation
biocarta	il2rbpathway	il-2 receptor beta chain in t cell activation
biocarta	pitx2pathway	multi-step regulation of transcription by pitx2
reactome	R-HSA-1640170	Cell Cycle
reactome	R-HSA-212436	Generic Transcription Pathway
reactome	R-HSA-453279	Mitotic G1-G1/S phases
reactome	R-HSA-69231	Cyclin D associated events in G1
reactome	R-HSA-69236	G1 Phase
reactome	R-HSA-69278	Cell Cycle, Mitotic
reactome	R-HSA-73857	RNA Polymerase II Transcription
reactome	R-HSA-74160	Gene expression (Transcription)
reactome	R-HSA-8878171	Transcriptional regulation by RUNX1
reactome	R-HSA-8934593	Regulation of RUNX1 Expression and Activity
wikipathways	WP1530	miRNA Regulation of DNA Damage Response
wikipathways	WP179	Cell Cycle
wikipathways	WP1991	SRF and miRs in Smooth Muscle Differentiation and Proliferation
wikipathways	WP2261	Signaling Pathways in Glioblastoma
wikipathways	WP306	Focal Adhesion
wikipathways	WP34	Ovarian Infertility Genes
wikipathways	WP399	Wnt Signaling Pathway and Pluripotency
wikipathways	WP4172	PI3K-Akt Signaling Pathway
wikipathways	WP4249	Hedgehog Signaling Pathway
wikipathways	WP428	Wnt Signaling Pathway
wikipathways	WP45	G1 to S cell cycle control
wikipathways	WP49	IL-2 Signaling Pathway
wikipathways	WP707	DNA Damage Response
wikipathways	WP710	DNA Damage Response (only ATM dependent)
pid	betacatenin_nuc_pathway	Regulation of nuclear beta catenin signaling and target gene transcription
pid	il2_stat5pathway	IL2 signaling events mediated by STAT5
pid	myc_activpathway	Validated targets of C-MYC transcriptional activation
pid	rb_1pathway	Regulation of retinoblastoma protein
kegg	hsa04068	FoxO signaling pathway - Homo sapiens (human)
kegg	hsa04110	Cell cycle - Homo sapiens (human)
kegg	hsa04115	p53 signaling pathway - Homo sapiens (human)
kegg	hsa04151	PI3K-Akt signaling pathway - Homo sapiens (human)
kegg	hsa04218	Cellular senescence - Homo sapiens (human)
kegg	hsa04310	Wnt signaling pathway - Homo sapiens (human)
kegg	hsa04340	Hedgehog signaling pathway - Homo sapiens (human)
kegg	hsa04390	Hippo signaling pathway - Homo sapiens (human)
kegg	hsa04510	Focal adhesion - Homo sapiens (human)
kegg	hsa04630	Jak-STAT signaling pathway - Homo sapiens (human)
kegg	hsa04917	Prolactin signaling pathway - Homo sapiens (human)
kegg	hsa05162	Measles - Homo sapiens (human)
kegg	hsa05165	Human papillomavirus infection - Homo sapiens (human)
kegg	hsa05166	HTLV-I infection - Homo sapiens (human)
kegg	hsa05200	Pathways in cancer - Homo sapiens (human)
kegg	hsa05202	Transcriptional misregulation in cancer - Homo sapiens (human)
kegg	hsa05203	Viral carcinogenesis - Homo sapiens (human)
kegg	hsa05206	MicroRNAs in cancer - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD292	NSC87877	1
iGMDRD85	Ursolic acid	2
iGMDRD351	GW843682X	1
iGMDRD237	ABT-751	1
iGMDRD945	ML214	3
iGMDRD84	Lovastatin acid	4
iGMDRD48	Dexamethasone	2
iGMDRD330	BRD4132	1
iGMDRD307	Manumycin A	5
iGMDRD584	VER 155008	3
iGMDRD248	BRD4354	2
iGMDRD560	MK-2206	4
iGMDRD286	Nsc 632839	3
iGMDRD367	Ro 28-1675	1
iGMDRD882	CIL41	5
iGMDRD329	Merck60	4
iGMDRD662	JQ-1	1
iGMDRD209	BRD6340	3
iGMDRD246	NPC26	3
iGMDRD82	Quiflapon	2
iGMDRD158	NSC141540	1
iGMDRD202	Curcumin	3
iGMDRD220	fumonisin B1	2
iGMDRD289	Parthenolide	3
iGMDRD105	Triptolide	1
iGMDRD6	AM-580	1
iGMDRD434	BMS-536924	2
iGMDRD481	Dactolisib	1
iGMDRD267	Oligomycin A	1
iGMDRD231	Importazole	1
iGMDRD446	LY 2183240	2
iGMDRD193	Fqi1	1
iGMDRD280	CYTOCHALASIN B	1
iGMDRD126	Tipifarnib	2
iGMDRD210	AC55649	3
iGMDRD554	CHEMBL1434137	1
iGMDRD387	CHIR-99021	1
iGMDRD599	Salermide	2
iGMDRD889	Compound 7d-cis	6
iGMDRD654	SL 0101-1	1
iGMDRD425	ERASTIN	1
iGMDRD427	ABT737	2
iGMDRD494	Neopeltolide	2
iGMDRD100	Zebularine	2
iGMDRD188	Piperlongumine	4
iGMDRD577	BIX01294	1
iGMDRD888	Compound 44	2
iGMDRD562	Navitoclax	2
iGMDRD183	CDK4/6 inhibitor	2
iGMDRD268	Cerulenin	2
iGMDRD23	Gossypol	2
iGMDRD524	ISX-9	6
iGMDRD255	SB225002	6
iGMDRD284	Palbociclib	1
iGMDRD478	ABT-888	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CCND2

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.