CCND2


Summary: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3). [provided by RefSeq, Sep 2014].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:123833
PHARMGKB IDPA26150
Map Location12p13.32

GO terms in CCND2


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IBA GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
BP IBA GO:0000278 mitotic cell cycle
BP IDA GO:0001934 positive regulation of protein phosphorylation
BP IEA GO:0007049 cell cycle
BP IBA GO:0007088 regulation of mitotic nuclear division
BP IEA GO:0007616 long-term memory
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Gene expression in normal tissue: CCND2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined41PI3K/MTOR signaling2Cell cycle2Ferroptosis1Apoptosis regulation1Biosynthesis of secondary metabolites1WNT signaling1Genome integrity1Stilbenoid, diarylheptanoid and gingerol biosynthesis1Neuroactive ligand-receptor interaction1

Pathways in CCND2


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Database
Pathway ID
Pathway Des.
biocarta cellcyclepathway cyclins and cell cycle regulation
biocarta il2rbpathway il-2 receptor beta chain in t cell activation
biocarta pitx2pathway multi-step regulation of transcription by pitx2
reactome R-HSA-1640170 Cell Cycle
reactome R-HSA-212436 Generic Transcription Pathway
reactome R-HSA-453279 Mitotic G1-G1/S phases
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD292 NSC87877 1
iGMDRD85 Ursolic acid 2
iGMDRD351 GW843682X 1
iGMDRD237 ABT-751 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CCND2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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