CCND2
Summary: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3). [provided by RefSeq, Sep 2014].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
Namecyclin D2 OMIM IDMIM:123833 Ensembl IDEnsembl:ENSG00000118971 HGNC IDHGNC:HGNC:1583 PHARMGKB IDPA26150 Map Location12p13.32 |
GO terms in CCND2
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
BP | IBA | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity |
BP | IBA | GO:0000278 | mitotic cell cycle |
BP | IDA | GO:0001934 | positive regulation of protein phosphorylation |
BP | IEA | GO:0007049 | cell cycle |
BP | IBA | GO:0007088 | regulation of mitotic nuclear division |
BP | IEA | GO:0007616 | long-term memory |
Gene expression in normal tissue: CCND2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CCND2
Database | Pathway ID | Pathway Des. |
---|---|---|
biocarta | cellcyclepathway | cyclins and cell cycle regulation |
biocarta | il2rbpathway | il-2 receptor beta chain in t cell activation |
biocarta | pitx2pathway | multi-step regulation of transcription by pitx2 |
reactome | R-HSA-1640170 | Cell Cycle |
reactome | R-HSA-212436 | Generic Transcription Pathway |
reactome | R-HSA-453279 | Mitotic G1-G1/S phases |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in CCND2
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
---|---|---|---|---|---|---|---|---|
No matching records found |