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KDM5C

Summary: This gene is a member of the SMCY homolog family and encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers. The DNA-binding motifs suggest this protein is involved in the regulation of transcription and chromatin remodeling. Mutations in this gene have been associated with X-linked cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Namelysine demethylase 5C OMIM IDMIM:314690 Ensembl IDEnsembl:ENSG00000126012 HGNC IDHGNC:HGNC:11114 PHARMGKB IDPA35964 Map LocationXp11.22

Gene Categories:

CLINICALLY ACTIONABLE HISTONE MODIFICATION DRUGGABLE GENOME

GO terms in KDM5C

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Term Type	Evidence Type	GO Term ID	GO Des.
CC	IBA	GO:0005634	nucleus
CC	IDA	GO:0005634	nucleus
CC	IDA	GO:0005654	nucleoplasm
CC	TAS	GO:0005654	nucleoplasm
CC	IDA	GO:0005829	cytosol
CC	IBA	GO:0035097	histone methyltransferase complex

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Gene expression in normal tissue: KDM5C

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KDM5C

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Database	Pathway ID	Pathway Des.
wikipathways	WP4018	Pathways in clear cell renal cell carcinoma
reactome	R-HSA-3214842	HDMs demethylate histones
reactome	R-HSA-3247509	Chromatin modifying enzymes
reactome	R-HSA-4839726	Chromatin organization

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD462	OSI-906 (Linsitinib)	1
iGMDRD456	Crizotinib	1
iGMDRD720	844499-71-4	1
iGMDRD136	Nutlin-3	1

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KDM5C

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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