KDM5C
Summary: This gene is a member of the SMCY homolog family and encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers. The DNA-binding motifs suggest this protein is involved in the regulation of transcription and chromatin remodeling. Mutations in this gene have been associated with X-linked cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| lysine demethylase 5C | MIM:314690 | Ensembl:ENSG00000126012 | HGNC:HGNC:11114 | PA35964 | Xp11.22 |
GO terms in KDM5C
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | IBA | GO:0035097 | histone methyltransferase complex |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0009636 | response to toxic substance |
| BP | IDA | GO:0034720 | histone H3-K4 demethylation |
| BP | IMP | GO:0034720 | histone H3-K4 demethylation |
| BP | ISS | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IEA | GO:0048511 | rhythmic process |
| BP | IEA | GO:0055114 | oxidation-reduction process |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IBA | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| MF | IEA | GO:0003677 | DNA binding |
| MF | IBA | GO:0003682 | chromatin binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008270 | zinc ion binding |
| MF | IBA | GO:0032452 | histone demethylase activity |
| MF | TAS | GO:0032452 | histone demethylase activity |
| MF | IDA | GO:0032453 | histone demethylase activity (H3-K4 specific) |
| MF | IMP | GO:0032453 | histone demethylase activity (H3-K4 specific) |
| MF | IBA | GO:0034647 | histone demethylase activity (H3-trimethyl-K4 specific) |
| MF | IBA | GO:0035064 | methylated histone binding |
| MF | IEA | GO:0051213 | dioxygenase activity |
Gene expression in normal tissue: KDM5C
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KDM5C
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP4018 | Pathways in clear cell renal cell carcinoma |
| reactome | R-HSA-3214842 | HDMs demethylate histones |
| reactome | R-HSA-3247509 | Chromatin modifying enzymes |
| reactome | R-HSA-4839726 | Chromatin organization |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD462 | OSI-906 (Linsitinib) | 1 |
| iGMDRD456 | Crizotinib | 1 |
| iGMDRD720 | 844499-71-4 | 1 |
| iGMDRD136 | Nutlin-3 | 1 |
| iGMDRD409 | Saracatinib | 1 |
| iGMDRD536 | PLX-4720 | 1 |
| iGMDRD352 | PD-0325901 | 1 |
| iGMDRD748 | PHA-665752 | 1 |
| iGMDRD68 | Paclitaxel | 1 |
| iGMDRD309 | 17AAG | 1 |
| iGMDRD396 | AS601245 | 1 |
| iGMDRD284 | Palbociclib | 1 |
| iGMDRD491 | TAE-684 | 1 |
| iGMDRD264 | Bryostatin 1 | 1 |
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD127 | Seliciclib | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KDM5C
CLASSFICATION
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