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JUN

Summary: This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul 2008].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
NameJun proto-oncogene, AP-1 transcription factor subunit OMIM IDMIM:165160 Ensembl IDEnsembl:ENSG00000177606 HGNC IDHGNC:HGNC:6204 PHARMGKB IDPA30006 Map Location1p32.1

Gene Categories:

DRUGGABLE GENOME DRUG RESISTANCE TUMOR SUPPRESSOR TRANSCRIPTION FACTOR BINDING TRANSCRIPTION FACTOR COMPLEX CLINICALLY ACTIONABLE

GO terms in JUN

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Term Type	Evidence Type	GO Term ID	GO Des.
MF	IBA	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
MF	IDA	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
MF	IBA	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	IC	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	ISA	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	ISM	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding

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Gene expression in normal tissue: JUN

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in JUN

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Database	Pathway ID	Pathway Des.
pid	ap1_pathway	AP-1 transcription factor network
pid	ar_tf_pathway	Regulation of Androgen receptor activity
pid	atf2_pathway	ATF-2 transcription factor network
pid	avb3_opn_pathway	Osteopontin-mediated events
pid	bcr_5pathway	BCR signaling pathway
pid	betacatenin_nuc_pathway	Regulation of nuclear beta catenin signaling and target gene transcription

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD885	Compound 110	1
iGMDRD289	Parthenolide	2
iGMDRD284	Palbociclib	1
iGMDRD424	Tamatinib	2

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in JUN

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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