JUN
Summary: This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| Jun proto-oncogene, AP-1 transcription factor subunit | MIM:165160 | Ensembl:ENSG00000177606 | HGNC:HGNC:6204 | PA30006 | 1p32.1 |
GO terms in JUN
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IDA | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding |
| MF | IBA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IC | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IMP | GO:0000982 | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IEA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IPI | GO:0001102 | RNA polymerase II activating transcription factor binding |
| MF | IC | GO:0001190 | transcriptional activator activity, RNA polymerase II transcription factor binding |
| MF | TAS | GO:0003677 | DNA binding |
| MF | IEA | GO:0003682 | chromatin binding |
| MF | IDA | GO:0003700 | DNA-binding transcription factor activity |
| MF | IC | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding |
| MF | IDA | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding |
| MF | IBA | GO:0003713 | transcription coactivator activity |
| MF | IDA | GO:0003713 | transcription coactivator activity |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IDA | GO:0005096 | GTPase activator activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008134 | transcription factor binding |
| MF | IPI | GO:0008134 | transcription factor binding |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IPI | GO:0031625 | ubiquitin protein ligase binding |
| MF | IDA | GO:0035497 | cAMP response element binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IDA | GO:0042803 | protein homodimerization activity |
| MF | IDA | GO:0044212 | transcription regulatory region DNA binding |
| MF | IDA | GO:0046982 | protein heterodimerization activity |
| MF | IPI | GO:0070412 | R-SMAD binding |
| MF | IEA | GO:0071837 | HMG box domain binding |
| CC | TAS | GO:0000228 | nuclear chromosome |
| CC | IBA | GO:0000790 | nuclear chromatin |
| CC | IDA | GO:0005634 | nucleus |
| CC | IBA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005667 | transcription factor complex |
| CC | IDA | GO:0005719 | nuclear euchromatin |
| CC | IEA | GO:0005829 | cytosol |
| CC | IEA | GO:0017053 | transcriptional repressor complex |
| CC | IDA | GO:0035976 | transcription factor AP-1 complex |
| CC | IMP | GO:0035976 | transcription factor AP-1 complex |
| BP | IBA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0001525 | angiogenesis |
| BP | IEA | GO:0001774 | microglial cell activation |
| BP | IEA | GO:0001836 | release of cytochrome c from mitochondria |
| BP | IEA | GO:0001889 | liver development |
| BP | IEA | GO:0001938 | positive regulation of endothelial cell proliferation |
| BP | IEA | GO:0003151 | outflow tract morphogenesis |
| BP | IEA | GO:0006366 | transcription by RNA polymerase II |
| BP | IDA | GO:0007179 | transforming growth factor beta receptor signaling pathway |
| BP | IDA | GO:0007265 | Ras protein signal transduction |
| BP | IEA | GO:0007568 | aging |
| BP | IEA | GO:0007612 | learning |
| BP | IEA | GO:0007623 | circadian rhythm |
| BP | IEA | GO:0008285 | negative regulation of cell proliferation |
| BP | IBA | GO:0009314 | response to radiation |
| BP | IBA | GO:0009612 | response to mechanical stimulus |
| BP | IBA | GO:0010033 | response to organic substance |
| BP | IEA | GO:0010634 | positive regulation of epithelial cell migration |
| BP | IBA | GO:0010941 | regulation of cell death |
| BP | IEA | GO:0030224 | monocyte differentiation |
| BP | IEA | GO:0031103 | axon regeneration |
| BP | IEA | GO:0031953 | negative regulation of protein autophosphorylation |
| BP | IBA | GO:0032496 | response to lipopolysaccharide |
| BP | IBA | GO:0032870 | cellular response to hormone stimulus |
| BP | IBA | GO:0034097 | response to cytokine |
| BP | IMP | GO:0034614 | cellular response to reactive oxygen species |
| BP | IEA | GO:0035026 | leading edge cell differentiation |
| BP | IEA | GO:0035994 | response to muscle stretch |
| BP | TAS | GO:0038095 | Fc-epsilon receptor signaling pathway |
| BP | IBA | GO:0042127 | regulation of cell proliferation |
| BP | IBA | GO:0042493 | response to drug |
| BP | IEA | GO:0042542 | response to hydrogen peroxide |
| BP | IMP | GO:0043065 | positive regulation of apoptotic process |
| BP | IDA | GO:0043392 | negative regulation of DNA binding |
| BP | IEA | GO:0043524 | negative regulation of neuron apoptotic process |
| BP | IEA | GO:0043525 | positive regulation of neuron apoptotic process |
| BP | IEA | GO:0043547 | positive regulation of GTPase activity |
| BP | IDA | GO:0043922 | negative regulation by host of viral transcription |
| BP | IDA | GO:0043923 | positive regulation by host of viral transcription |
| BP | IBA | GO:0045597 | positive regulation of cell differentiation |
| BP | IEA | GO:0045657 | positive regulation of monocyte differentiation |
| BP | IEA | GO:0045740 | positive regulation of DNA replication |
| BP | IDA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IMP | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IBA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IC | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0048146 | positive regulation of fibroblast proliferation |
| BP | TAS | GO:0051090 | regulation of DNA-binding transcription factor activity |
| BP | IEA | GO:0051365 | cellular response to potassium ion starvation |
| BP | IBA | GO:0051591 | response to cAMP |
| BP | IBA | GO:0051726 | regulation of cell cycle |
| BP | IEA | GO:0051899 | membrane depolarization |
| BP | IDA | GO:0060395 | SMAD protein signal transduction |
| BP | IEA | GO:0061029 | eyelid development in camera-type eye |
| BP | IEA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IMP | GO:0071276 | cellular response to cadmium ion |
| BP | IEA | GO:0071277 | cellular response to calcium ion |
| BP | IMP | GO:1902895 | positive regulation of pri-miRNA transcription by RNA polymerase II |
| BP | ISS | GO:1902895 | positive regulation of pri-miRNA transcription by RNA polymerase II |
| BP | IMP | GO:1904707 | positive regulation of vascular smooth muscle cell proliferation |
| BP | IMP | GO:1990441 | negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress |
| BP | IDA | GO:2000144 | positive regulation of DNA-templated transcription, initiation |
Gene expression in normal tissue: JUN
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in JUN
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | ap1_pathway | AP-1 transcription factor network |
| pid | ar_tf_pathway | Regulation of Androgen receptor activity |
| pid | atf2_pathway | ATF-2 transcription factor network |
| pid | avb3_opn_pathway | Osteopontin-mediated events |
| pid | bcr_5pathway | BCR signaling pathway |
| pid | betacatenin_nuc_pathway | Regulation of nuclear beta catenin signaling and target gene transcription |
| pid | cd40_pathway | CD40/CD40L signaling |
| pid | cd8tcrdownstreampathway | Downstream signaling in naïve CD8+ T cells |
| pid | cdc42_pathway | CDC42 signaling events |
| pid | endothelinpathway | Endothelins |
| pid | era_genomic_pathway | Validated nuclear estrogen receptor alpha network |
| pid | erbb1_downstream_pathway | ErbB1 downstream signaling |
| pid | erbb2erbb3pathway | ErbB2/ErbB3 signaling events |
| pid | fak_pathway | Signaling events mediated by focal adhesion kinase |
| pid | fcer1pathway | Fc-epsilon receptor I signaling in mast cells |
| pid | fgf_pathway | FGF signaling pathway |
| pid | fra_pathway | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| pid | hif1_tfpathway | HIF-1-alpha transcription factor network |
| pid | hnf3apathway | FOXA1 transcription factor network |
| pid | il12_stat4pathway | IL12 signaling mediated by STAT4 |
| pid | il1pathway | IL1-mediated signaling events |
| pid | il2_1pathway | IL2-mediated signaling events |
| pid | il6_7pathway | IL6-mediated signaling events |
| pid | ilk_pathway | Integrin-linked kinase signaling |
| pid | lysophospholipid_pathway | LPA receptor mediated events |
| pid | met_pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| pid | nephrin_neph1_pathway | Nephrin/Neph1 signaling in the kidney podocyte |
| pid | nfat_tfpathway | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| pid | p38alphabetadownstreampathway | Signaling mediated by p38-alpha and p38-beta |
| pid | p53downstreampathway | Direct p53 effectors |
| pid | pdgfrapathway | PDGFR-alpha signaling pathway |
| pid | pdgfrbpathway | PDGFR-beta signaling pathway |
| pid | ps1pathway | Presenilin action in Notch and Wnt signaling |
| pid | rac1_pathway | RAC1 signaling pathway |
| pid | rb_1pathway | Regulation of retinoblastoma protein |
| pid | reg_gr_pathway | Glucocorticoid receptor regulatory network |
| pid | ret_pathway | Signaling events regulated by Ret tyrosine kinase |
| pid | rhoa_pathway | RhoA signaling pathway |
| pid | s1p_s1p2_pathway | S1P2 pathway |
| pid | smad2_3nuclearpathway | Regulation of nuclear SMAD2/3 signaling |
| pid | tcrcalciumpathway | Calcium signaling in the CD4+ TCR pathway |
| pid | tcrjnkpathway | JNK signaling in the CD4+ TCR pathway |
| pid | telomerasepathway | Regulation of Telomerase |
| pharmgkb | PA162356267 | EGFR Inhibitor Pathway, Pharmacodynamics |
| pharmgkb | PA165980050 | Vemurafenib Pathway, Pharmacodynamics |
| pharmgkb | PA165980050 | update your name in edit mode |
| pharmgkb | PA165985892 | Tacrolimus/Cyclosporine Pathway, Pharmacodynamics |
| smpdb | SMP00320 | Intracellular Signalling Through Adenosine Receptor A2a and Adenosine |
| smpdb | SMP00321 | Intracellular Signalling Through Adenosine Receptor A2b and Adenosine |
| wikipathways | WP127 | IL-5 Signaling Pathway |
| wikipathways | WP138 | Androgen receptor signaling pathway |
| wikipathways | WP1449 | Regulation of toll-like receptor signaling pathway |
| wikipathways | WP1528 | Physiological and Pathological Hypertrophy of the Heart |
| wikipathways | WP1772 | Apoptosis Modulation and Signaling |
| wikipathways | WP195 | IL-1 signaling pathway |
| wikipathways | WP1984 | Integrated Breast Cancer Pathway |
| wikipathways | WP2018 | RANKL-RANK (Receptor activator of NFKB (ligand)) Signaling Pathway |
| wikipathways | WP2032 | Human Thyroid Stimulating Hormone (TSH) signaling pathway |
| wikipathways | WP2036 | TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway |
| wikipathways | WP2037 | Prolactin Signaling Pathway |
| wikipathways | WP2263 | Androgen Receptor Network in Prostate Cancer |
| wikipathways | WP23 | B Cell Receptor Signaling Pathway |
| wikipathways | WP231 | TNF alpha Signaling Pathway |
| wikipathways | WP2324 | AGE-RAGE pathway |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP2435 | Quercetin and Nf-kB- AP-1 Induced Cell Apoptosis |
| wikipathways | WP2512 | Integrated Lung Cancer Pathway |
| wikipathways | WP2516 | ATM Signaling Pathway |
| wikipathways | WP254 | Apoptosis |
| wikipathways | WP2571 | Polycystic Kidney Disease Pathway |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP28 | Selenium Metabolism and Selenoproteins |
| wikipathways | WP286 | IL-3 Signaling Pathway |
| wikipathways | WP2873 | Aryl Hydrocarbon Receptor Pathway |
| wikipathways | WP2880 | Glucocorticoid Receptor Pathway |
| wikipathways | WP2881 | Estrogen Receptor Pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP289 | Myometrial Relaxation and Contraction Pathways |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP313 | Signaling of Hepatocyte Growth Factor Receptor |
| wikipathways | WP314 | Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation |
| wikipathways | WP3286 | Copper homeostasis |
| wikipathways | WP3301 | MFAP5-mediated ovarian cancer cell motility and invasiveness |
| wikipathways | WP3611 | Photodynamic therapy-induced AP-1 survival signaling. |
| wikipathways | WP3612 | Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling |
| wikipathways | WP3639 | Apoptotic Signaling Pathway |
| wikipathways | WP3646 | Hepatitis C and Hepatocellular Carcinoma |
| wikipathways | WP366 | TGF-beta Signaling Pathway |
| wikipathways | WP3680 | Association Between Physico-Chemical Features and Toxicity Associated Pathways |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3863 | T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3927 | BMP Signaling Pathway in Eyelid Development |
| wikipathways | WP3931 | ESC Pluripotency Pathways |
| wikipathways | WP3972 | PDGFR-beta pathway |
| wikipathways | WP399 | Wnt Signaling Pathway and Pluripotency |
| wikipathways | WP4205 | MET in type 1 papillary renal cell carcinoma |
| wikipathways | WP4216 | Chromosomal and microsatellite instability in colorectal cancer |
| wikipathways | WP422 | MAPK Cascade |
| wikipathways | WP428 | Wnt Signaling Pathway |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| wikipathways | WP481 | Insulin Signaling |
| wikipathways | WP49 | IL-2 Signaling Pathway |
| wikipathways | WP560 | TGF-beta Receptor Signaling |
| wikipathways | WP615 | Senescence and Autophagy in Cancer |
| wikipathways | WP673 | ErbB Signaling Pathway |
| wikipathways | WP69 | T-Cell antigen Receptor (TCR) Signaling Pathway |
| wikipathways | WP706 | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
| wikipathways | WP710 | DNA Damage Response (only ATM dependent) |
| wikipathways | WP712 | Estrogen signaling pathway |
| wikipathways | WP75 | Toll-like Receptor Signaling Pathway |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04012 | ErbB signaling pathway - Homo sapiens (human) |
| kegg | hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
| kegg | hsa04137 | Mitophagy - animal - Homo sapiens (human) |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| kegg | hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04530 | Tight junction - Homo sapiens (human) |
| kegg | hsa04620 | Toll-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04657 | IL-17 signaling pathway - Homo sapiens (human) |
| kegg | hsa04658 | Th1 and Th2 cell differentiation - Homo sapiens (human) |
| kegg | hsa04659 | Th17 cell differentiation - Homo sapiens (human) |
| kegg | hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04662 | B cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04668 | TNF signaling pathway - Homo sapiens (human) |
| kegg | hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| kegg | hsa04912 | GnRH signaling pathway - Homo sapiens (human) |
| kegg | hsa04915 | Estrogen signaling pathway - Homo sapiens (human) |
| kegg | hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| kegg | hsa04926 | Relaxin signaling pathway - Homo sapiens (human) |
| kegg | hsa04932 | Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) |
| kegg | hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
| kegg | hsa05030 | Cocaine addiction - Homo sapiens (human) |
| kegg | hsa05031 | Amphetamine addiction - Homo sapiens (human) |
| kegg | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human) |
| kegg | hsa05132 | Salmonella infection - Homo sapiens (human) |
| kegg | hsa05133 | Pertussis - Homo sapiens (human) |
| kegg | hsa05140 | Leishmaniasis - Homo sapiens (human) |
| kegg | hsa05142 | Chagas disease (American trypanosomiasis) - Homo sapiens (human) |
| kegg | hsa05161 | Hepatitis B - Homo sapiens (human) |
| kegg | hsa05164 | Influenza A - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| kegg | hsa05168 | Herpes simplex infection - Homo sapiens (human) |
| kegg | hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| kegg | hsa05210 | Colorectal cancer - Homo sapiens (human) |
| kegg | hsa05211 | Renal cell carcinoma - Homo sapiens (human) |
| kegg | hsa05224 | Breast cancer - Homo sapiens (human) |
| kegg | hsa05231 | Choline metabolism in cancer - Homo sapiens (human) |
| kegg | hsa05321 | Inflammatory bowel disease (IBD) - Homo sapiens (human) |
| kegg | hsa05323 | Rheumatoid arthritis - Homo sapiens (human) |
| kegg | hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
| netpath | Pathway_Alpha6Beta4Integrin | Alpha6Beta4Integrin |
| netpath | Pathway_AndrogenReceptor | AndrogenReceptor |
| netpath | Pathway_BCR | BCR |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_Gastrin | Gastrin |
| netpath | Pathway_IL1 | IL1 |
| netpath | Pathway_IL2 | IL2 |
| netpath | Pathway_IL5 | IL5 |
| netpath | Pathway_IL6 | IL6 |
| netpath | Pathway_KitReceptor | KitReceptor |
| netpath | Pathway_Prolactin | Prolactin |
| netpath | Pathway_RAGE | RAGE |
| netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
| netpath | Pathway_TNFalpha | TNFalpha |
| netpath | Pathway_Wnt | Wnt |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade |
| reactome | R-HSA-166058 | MyD88:Mal cascade initiated on plasma membrane |
| reactome | R-HSA-166166 | MyD88-independent TLR4 cascade |
| reactome | R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade |
| reactome | R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade |
| reactome | R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade |
| reactome | R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade |
| reactome | R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade |
| reactome | R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| reactome | R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade |
| reactome | R-HSA-1912408 | Pre-NOTCH Transcription and Translation |
| reactome | R-HSA-1912422 | Pre-NOTCH Expression and Processing |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling |
| reactome | R-HSA-2559580 | Oxidative Stress Induced Senescence |
| reactome | R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) |
| reactome | R-HSA-2559583 | Cellular Senescence |
| reactome | R-HSA-2871796 | FCERI mediated MAPK activation |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-448424 | Interleukin-17 signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases |
| reactome | R-HSA-450294 | MAP kinase activation |
| reactome | R-HSA-450341 | Activation of the AP-1 family of transcription factors |
| reactome | R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogenesis |
| reactome | R-HSA-5619507 | Activation of HOX genes during differentiation |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5687128 | MAPK6/MAPK4 signaling |
| reactome | R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes |
| reactome | R-HSA-6807070 | PTEN Regulation |
| reactome | R-HSA-6807070 | PTEN Regulation |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
| reactome | R-HSA-8863678 | Neurodegenerative Diseases |
| reactome | R-HSA-8939211 | ESR-mediated signaling |
| reactome | R-HSA-8943724 | Regulation of PTEN gene transcription |
| reactome | R-HSA-8943724 | Regulation of PTEN gene transcription |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9006931 | Signaling by Nuclear Receptors |
| reactome | R-HSA-9018519 | Estrogen-dependent gene expression |
| reactome | R-HSA-937061 | TRIF(TICAM1)-mediated TLR4 signaling |
| reactome | R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| reactome | R-HSA-975155 | MyD88 dependent cascade initiated on endosome |
| reactome | R-HSA-975871 | MyD88 cascade initiated on plasma membrane |
| biocarta | 41bbpathway | the 41bb-dependent immune response |
| biocarta | agrpathway | agrin in postsynaptic differentiation |
| biocarta | arenrf2pathway | oxidative stress induced gene expression via nrf2 |
| biocarta | at1rpathway | angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling |
| biocarta | atmpathway | atm signaling pathway |
| biocarta | bcrpathway | bcr signaling pathway |
| biocarta | cardiacegfpathway | role of egf receptor transactivation by gpcrs in cardiac hypertrophy |
| biocarta | ccr5pathway | pertussis toxin-insensitive ccr5 signaling in macrophage |
| biocarta | cdmacpathway | cadmium induces dna synthesis and proliferation in macrophages |
| biocarta | d4gdipathway | d4gdi signaling pathway |
| biocarta | dreampathway | repression of pain sensation by the transcriptional regulator dream |
| biocarta | eponfkbpathway | erythropoietin mediated neuroprotection through nf-kb |
| biocarta | etspathway | mets affect on macrophage differentiation |
| biocarta | fcer1pathway | fc epsilon receptor i signaling in mast cells |
| biocarta | gleevecpathway | inhibition of cellular proliferation by gleevec |
| biocarta | hbxpathway | calcium signaling by hbx of hepatitis b virus |
| biocarta | hifpathway | hypoxia-inducible factor in the cardivascular system |
| biocarta | igf1pathway | igf-1 signaling pathway |
| biocarta | il12pathway | il12 and stat4 dependent signaling pathway in th1 development |
| biocarta | il1rpathway | signal transduction through il1r |
| biocarta | keratinocytepathway | keratinocyte differentiation |
| biocarta | mapkpathway | mapkinase signaling pathway |
| biocarta | ngfpathway | nerve growth factor pathway (ngf) |
| biocarta | pcafpathway | the information processing pathway at the ifn beta enhancer |
| biocarta | pdgfpathway | pdgf signaling pathway |
| biocarta | pparapathway | mechanism of gene regulation by peroxisome proliferators via ppara |
| biocarta | pyk2pathway | links between pyk2 and map kinases |
| biocarta | stresspathway | tnf/stress related signaling |
| biocarta | tcrpathway | t cell receptor signaling pathway |
| biocarta | tollpathway | toll-like receptor pathway |
| biocarta | tpopathway | tpo signaling pathway |
| biocarta | tsp1pathway | tsp-1 induced apoptosis in microvascular endothelial cell |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD885 | Compound 110 | 1 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD284 | Palbociclib | 1 |
| iGMDRD424 | Tamatinib | 2 |
| iGMDRD512 | nutlin 3 | 1 |
| iGMDRD137 | Indisulam | 6 |
| iGMDRD158 | NSC141540 | 1 |
| iGMDRD25 | 138402-11-6 | 1 |
| iGMDRD147 | Prima-1 | 1 |
| iGMDRD394 | BX-795 | 2 |
| iGMDRD398 | Sepantronium | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in JUN
CLASSFICATION
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