CDKN1C
Summary: This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:600856 Ensembl IDEnsembl:ENSG00000129757 HGNC IDHGNC:HGNC:1786 PHARMGKB IDPA26320 Map Location11p15.4 | |||||
GO terms in CDKN1C
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IMP | GO:0004860 | protein kinase inhibitor activity |
| MF | IEA | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0044877 | protein-containing complex binding |
| BP | IEA | GO:0007050 | cell cycle arrest |
| BP | IEA | GO:0007346 | regulation of mitotic cell cycle |
Gene expression in normal tissue: CDKN1C
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CDKN1C
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-453279 | Mitotic G1-G1/S phases |
| reactome | R-HSA-69231 | Cyclin D associated events in G1 |
| reactome | R-HSA-69236 | G1 Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD284 | Palbociclib | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CDKN1C
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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