Summary: This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010].

cyclin dependent kinase inhibitor 1CMIM:600856Ensembl:ENSG00000129757HGNC:HGNC:1786PA2632011p15.4

GO terms in CDKN1C

Term TypeEvidence TypeGO Term IDGO Des.
MFIMPGO:0004860protein kinase inhibitor activity
MFIEAGO:0004861cyclin-dependent protein serine/threonine kinase inhibitor activity
MFIPIGO:0005515protein binding
MFIPIGO:0044877protein-containing complex binding
BPIEAGO:0007050cell cycle arrest
BPIEAGO:0007346regulation of mitotic cell cycle
BPIMPGO:0030511positive regulation of transforming growth factor beta receptor signaling pathway
BPIDAGO:0033673negative regulation of kinase activity
BPIDAGO:0042326negative regulation of phosphorylation
BPIDAGO:0045892negative regulation of transcription, DNA-templated
BPIGIGO:0045893positive regulation of transcription, DNA-templated
BPIMPGO:0050680negative regulation of epithelial cell proliferation
BPIEAGO:0071901negative regulation of protein serine/threonine kinase activity
BPIMPGO:1904030negative regulation of cyclin-dependent protein kinase activity

Gene expression in normal tissue: CDKN1C

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CDKN1C

DatabasePathway IDPathway Des.
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-453279Mitotic G1-G1/S phases
reactomeR-HSA-69231Cyclin D associated events in G1
reactomeR-HSA-69236G1 Phase
reactomeR-HSA-69278Cell Cycle, Mitotic
wikipathwaysWP2002miR-targeted genes in epithelium - TarBase
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase
wikipathwaysWP2572Primary Focal Segmental Glomerulosclerosis FSGS
wikipathwaysWP2855Dopaminergic Neurogenesis
wikipathwaysWP2880Glucocorticoid Receptor Pathway
wikipathwaysWP2882Nuclear Receptors Meta-Pathway
wikipathwaysWP3941Oxidative Damage
wikipathwaysWP45G1 to S cell cycle control
wikipathwaysWP474Endochondral Ossification
kegghsa04110Cell cycle - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CDKN1C