CDK6
Summary: The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Altered expression of this gene has been observed in multiple human cancers. A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly. [provided by RefSeq, Aug 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cyclin dependent kinase 6 | MIM:603368 | Ensembl:ENSG00000105810 | HGNC:HGNC:1777 | PA103 | 7q21.2 |
GO terms in CDK6
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity |
| MF | IDA | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005524 | ATP binding |
| MF | IPI | GO:0030332 | cyclin binding |
| MF | IPI | GO:0098770 | FBXO family protein binding |
| CC | IDA | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex |
| CC | IDA | GO:0001726 | ruffle |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005813 | centrosome |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| BP | TAS | GO:0000082 | G1/S transition of mitotic cell cycle |
| BP | IDA | GO:0001954 | positive regulation of cell-matrix adhesion |
| BP | IDA | GO:0003323 | type B pancreatic cell development |
| BP | IBA | GO:0006468 | protein phosphorylation |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0007050 | cell cycle arrest |
| BP | TAS | GO:0008285 | negative regulation of cell proliferation |
| BP | IEP | GO:0009615 | response to virus |
| BP | IDA | GO:0010468 | regulation of gene expression |
| BP | IMP | GO:0010468 | regulation of gene expression |
| BP | ISS | GO:0014002 | astrocyte development |
| BP | ISS | GO:0021542 | dentate gyrus development |
| BP | ISS | GO:0021670 | lateral ventricle development |
| BP | TAS | GO:0031658 | negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle |
| BP | IMP | GO:0042063 | gliogenesis |
| BP | IMP | GO:0043697 | cell dedifferentiation |
| BP | TAS | GO:0045596 | negative regulation of cell differentiation |
| BP | IDA | GO:0045638 | negative regulation of myeloid cell differentiation |
| BP | IMP | GO:0045646 | regulation of erythrocyte differentiation |
| BP | IDA | GO:0045656 | negative regulation of monocyte differentiation |
| BP | IDA | GO:0045668 | negative regulation of osteoblast differentiation |
| BP | IDA | GO:0045786 | negative regulation of cell cycle |
| BP | IMP | GO:0048146 | positive regulation of fibroblast proliferation |
| BP | ISS | GO:0048699 | generation of neurons |
| BP | IMP | GO:0050680 | negative regulation of epithelial cell proliferation |
| BP | IEA | GO:0051301 | cell division |
| BP | ISS | GO:2000145 | regulation of cell motility |
| BP | IDA | GO:2000773 | negative regulation of cellular senescence |
Gene expression in normal tissue: CDK6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CDK6
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2559580 | Oxidative Stress Induced Senescence |
| reactome | R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) |
| reactome | R-HSA-2559583 | Cellular Senescence |
| reactome | R-HSA-2559585 | Oncogene Induced Senescence |
| reactome | R-HSA-453279 | Mitotic G1-G1/S phases |
| reactome | R-HSA-69231 | Cyclin D associated events in G1 |
| reactome | R-HSA-69236 | G1 Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8878171 | Transcriptional regulation by RUNX1 |
| reactome | R-HSA-8934593 | Regulation of RUNX1 Expression and Activity |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| biocarta | cellcyclepathway | cyclins and cell cycle regulation |
| biocarta | efppathway | estrogen responsive protein efp controls cell cycle and breast tumors growth |
| biocarta | g1pathway | cell cycle: g1/s check point |
| biocarta | raccycdpathway | influence of ras and rho proteins on g1 to s transition |
| netpath | Pathway_BCR | BCR |
| netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
| netpath | Pathway_Wnt | Wnt |
| pid | ar_pathway | Coregulation of Androgen receptor activity |
| pid | cmyb_pathway | C-MYB transcription factor network |
| pid | il2_stat5pathway | IL2 signaling events mediated by STAT5 |
| pid | p73pathway | p73 transcription factor network |
| pid | rb_1pathway | Regulation of retinoblastoma protein |
| kegg | hsa04110 | Cell cycle - Homo sapiens (human) |
| kegg | hsa04115 | p53 signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| kegg | hsa04934 | Cushing,s syndrome - Homo sapiens (human) |
| kegg | hsa05161 | Hepatitis B - Homo sapiens (human) |
| kegg | hsa05162 | Measles - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| kegg | hsa05212 | Pancreatic cancer - Homo sapiens (human) |
| kegg | hsa05214 | Glioma - Homo sapiens (human) |
| kegg | hsa05218 | Melanoma - Homo sapiens (human) |
| kegg | hsa05220 | Chronic myeloid leukemia - Homo sapiens (human) |
| kegg | hsa05222 | Small cell lung cancer - Homo sapiens (human) |
| kegg | hsa05223 | Non-small cell lung cancer - Homo sapiens (human) |
| kegg | hsa05224 | Breast cancer - Homo sapiens (human) |
| kegg | hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| wikipathways | WP1530 | miRNA Regulation of DNA Damage Response |
| wikipathways | WP1545 | miRNAs involved in DNA damage response |
| wikipathways | WP179 | Cell Cycle |
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2003 | miR-targeted genes in leukocytes - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2249 | Metastatic brain tumor |
| wikipathways | WP2261 | Signaling Pathways in Glioblastoma |
| wikipathways | WP2446 | Retinoblastoma (RB) in Cancer |
| wikipathways | WP363 | Wnt Signaling Pathway |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP4204 | Tumor suppressor activity of SMARCB1 |
| wikipathways | WP45 | G1 to S cell cycle control |
| wikipathways | WP707 | DNA Damage Response |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD137 | Indisulam | 3 |
| iGMDRD101 | Fulvestrant | 2 |
| iGMDRD284 | Palbociclib | 2 |
| iGMDRD309 | 17AAG | 1 |
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD577 | BIX01294 | 6 |
| iGMDRD662 | JQ-1 | 2 |
| iGMDRD562 | Navitoclax | 6 |
| iGMDRD190 | Nilotinib | 1 |
| iGMDRD322 | FK 866 | 2 |
| iGMDRD136 | Nutlin-3 | 1 |
| iGMDRD877 | CDK6 inhibitor | 2 |
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD638 | Ribociclib | 15 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD135 | Lenalidomide | 1 |
| iGMDRD536 | PLX-4720 | 1 |
| iGMDRD352 | PD-0325901 | 1 |
| iGMDRD280 | CYTOCHALASIN B | 4 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CDK6
CLASSFICATION
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