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iGMDRD135

Canonical SMILES: C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC=C3N

InChI: InChI=1S/C13H13N3O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6,14H2,(H,15,17,18)

InChI Key: GOTYRUGSSMKFNF-UHFFFAOYSA-N

Standard Name	CHEMBL	Pubchem CID	KEGG Drug ID	DRUGBANK ID	Drug Status	Drug targets (TTD)	Drug Type
Lenalidomide	CHEMBL848	216326	D04687	DB00480	Alone	DAP001255	Small Molecule

Drug Class:

Acids, Carbocyclic Angiogenesis Inhibitors Angiogenesis Modulating Agents Antineoplastic Agents Antineoplastic and Immunomodulating Agents Carboxylic Acids Growth Inhibitors Growth Substances Heterocyclic Compounds Heterocyclic Compounds, 1-Ring Heterocyclic Compounds, 2-Ring Imides Immunologic Factors Immunosuppressive Agents Isoindoles Myelosuppressive Agents P-glycoprotein/ABCB1 Substrates Phthalic Acids Phthalimides Piperidines Piperidones Thalidomide Analog

Drug Targets:

TNFA CRBN (Q96SW2)TNFSF11 (O14788)CDH5 (P33151)PTGS2 (P35354)

Drug Pathways:

Cytokine-cytokine receptor interaction NF-kappa B signaling pathway Apoptosis Hematopoietic cell lineage Natural killer cell mediated cytotoxicity TNF signaling pathway Protein stability and degradation

Drug Synonyms:

Lenalidomide (USAN/INN)Revlimid (TN)

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
3845	KRAS	1
9757	KMT2B	1
1387	CREBBP	1
7307	U2AF1	1
1021	CDK6	1
608	TNFRSF17	1
25816	TNFAIP8	1
1029	CDKN2A	1
51185	CRBN	4
7157	TP53	1
4869	NPM1	1
7422	VEGFA	1
29072	SETD2	1
3105	HLA-A	1
23236	PLCB1	1
5728	PTEN	1
4893	NRAS	1
7040	TGFB1	1

Gene in drug-gene network: Network Plot

Models in Lenalidomide

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Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.