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CRBN

Summary: This gene encodes a protein related to the Lon protease protein family. In rodents and other mammals this gene product is found in the cytoplasm localized with a calcium channel membrane protein, and is thought to play a role in brain development. Mutations in this gene are associated with autosomal recessive nonsyndromic cognitive disability. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Namecereblon OMIM IDMIM:609262 Ensembl IDEnsembl:ENSG00000113851 HGNC IDHGNC:HGNC:30185 PHARMGKB IDPA134926851 Map Location3p26.2

GO terms in CRBN

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Term Type	Evidence Type	GO Term ID	GO Des.
BP	IEA	GO:0016567	protein ubiquitination
BP	IMP	GO:0016567	protein ubiquitination
BP	IEA	GO:0032463	negative regulation of protein homooligomerization
BP	IEA	GO:0034766	negative regulation of ion transmembrane transport
BP	IMP	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
BP	IEA	GO:0090073	positive regulation of protein homodimerization activity

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Gene expression in normal tissue: CRBN

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CRBN

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Database	Pathway ID	Pathway Des.
No matching records found

Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD115	Pomalidomide	4
iGMDRD135	Lenalidomide	4

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CRBN

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
No matching records found

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