TGFB1


Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease. [provided by RefSeq, Aug 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
transforming growth factor beta 1MIM:190180Ensembl:ENSG00000105329HGNC:HGNC:11766PA35019q13.2

GO terms in TGFB1


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0003823antigen binding
MFIBAGO:0005114type II transforming growth factor beta receptor binding
MFIDAGO:0005114type II transforming growth factor beta receptor binding
MFIMPGO:0005114type II transforming growth factor beta receptor binding
MFIPIGO:0005114type II transforming growth factor beta receptor binding
MFIBAGO:0005125cytokine activity
MFTASGO:0005125cytokine activity
MFIBAGO:0005160transforming growth factor beta receptor binding
MFTASGO:0005160transforming growth factor beta receptor binding
MFIPIGO:0005515protein binding
MFIEAGO:0008083growth factor activity
MFIPIGO:0019899enzyme binding
MFIMPGO:0034713type I transforming growth factor beta receptor binding
MFIPIGO:0034713type I transforming growth factor beta receptor binding
MFIMPGO:0034714type III transforming growth factor beta receptor binding
MFIPIGO:0034714type III transforming growth factor beta receptor binding
MFIPIGO:0042802identical protein binding
MFIEAGO:0042803protein homodimerization activity
MFIEAGO:0043539protein serine/threonine kinase activator activity
MFIEAGO:0046982protein heterodimerization activity
MFIEAGO:0047485protein N-terminus binding
CCTASGO:0005576extracellular region
CCIBAGO:0005615extracellular space
CCIDAGO:0005615extracellular space
CCIDAGO:0005634nucleus
CCIDAGO:0005737cytoplasm
CCTASGO:0005796Golgi lumen
CCTASGO:0005886plasma membrane
CCIDAGO:0005902microvillus
CCIMPGO:0009986cell surface
CCIEAGO:0030424axon
CCISSGO:0031012extracellular matrix
CCTASGO:0031093platelet alpha granule lumen
CCIEAGO:0043025neuronal cell body
CCHDAGO:0062023collagen-containing extracellular matrix
CCHDAGO:0072562blood microparticle
BPIDAGO:0000060protein import into nucleus, translocation
BPIEAGO:0000122negative regulation of transcription by RNA polymerase II
BPIMPGO:0000165MAPK cascade
BPISSGO:0001570vasculogenesis
BPIEAGO:0001657ureteric bud development
BPIEAGO:0001666response to hypoxia
BPIDAGO:0001837epithelial to mesenchymal transition
BPISSGO:0001843neural tube closure
BPIDAGO:0001933negative regulation of protein phosphorylation
BPIDAGO:0001934positive regulation of protein phosphorylation
BPIEAGO:0002028regulation of sodium ion transport
BPIDAGO:0002062chondrocyte differentiation
BPIDAGO:0002244hematopoietic progenitor cell differentiation
BPTASGO:0002248connective tissue replacement involved in inflammatory response wound healing
BPIEAGO:0002460adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
BPIEAGO:0002513tolerance induction to self antigen
BPTASGO:0002576platelet degranulation
BPISSGO:0003179heart valve morphogenesis
BPISSGO:0006468protein phosphorylation
BPIDAGO:0006611protein export from nucleus
BPIDAGO:0006754ATP biosynthetic process
BPIDAGO:0006796phosphate-containing compound metabolic process
BPIEAGO:0006874cellular calcium ion homeostasis
BPIDAGO:0006954inflammatory response
BPIDAGO:0007050cell cycle arrest
BPIDAGO:0007093mitotic cell cycle checkpoint
BPIDAGO:0007173epidermal growth factor receptor signaling pathway
BPIBAGO:0007179transforming growth factor beta receptor signaling pathway
BPIDAGO:0007179transforming growth factor beta receptor signaling pathway
BPTASGO:0007179transforming growth factor beta receptor signaling pathway
BPIDAGO:0007182common-partner SMAD protein phosphorylation
BPIDAGO:0007183SMAD protein complex assembly
BPIEAGO:0007219Notch signaling pathway
BPIEAGO:0007406negative regulation of neuroblast proliferation
BPIEPGO:0007435salivary gland morphogenesis
BPIEAGO:0007492endoderm development
BPISSGO:0007507heart development
BPIEAGO:0007565female pregnancy
BPIEAGO:0007568aging
BPIDAGO:0008284positive regulation of cell proliferation
BPIMPGO:0008284positive regulation of cell proliferation
BPIDAGO:0008285negative regulation of cell proliferation
BPIMPGO:0008285negative regulation of cell proliferation
BPIEAGO:0008354germ cell migration
BPIEPGO:0009611response to wounding
BPIEAGO:0009749response to glucose
BPIEAGO:0009817defense response to fungus, incompatible interaction
BPIEAGO:0010469regulation of signaling receptor activity
BPTASGO:0010575positive regulation of vascular endothelial growth factor production
BPIDAGO:0010628positive regulation of gene expression
BPIGIGO:0010628positive regulation of gene expression
BPIMPGO:0010628positive regulation of gene expression
BPISSGO:0010628positive regulation of gene expression
BPIDAGO:0010629negative regulation of gene expression
BPIGIGO:0010629negative regulation of gene expression
BPISSGO:0010629negative regulation of gene expression
BPICGO:0010716negative regulation of extracellular matrix disassembly
BPIDAGO:0010718positive regulation of epithelial to mesenchymal transition
BPNASGO:0010718positive regulation of epithelial to mesenchymal transition
BPICGO:0010742macrophage derived foam cell differentiation
BPIDAGO:0010763positive regulation of fibroblast migration
BPIDAGO:0010800positive regulation of peptidyl-threonine phosphorylation
BPIBAGO:0010862positive regulation of pathway-restricted SMAD protein phosphorylation
BPIDAGO:0010862positive regulation of pathway-restricted SMAD protein phosphorylation
BPIDAGO:0010936negative regulation of macrophage cytokine production
BPIEAGO:0014003oligodendrocyte development
BPISSGO:0016202regulation of striated muscle tissue development
BPIDAGO:0016477cell migration
BPIDAGO:0017015regulation of transforming growth factor beta receptor signaling pathway
BPIDAGO:0019049evasion or tolerance of host defenses by virus
BPTASGO:0019221cytokine-mediated signaling pathway
BPISSGO:0021915neural tube development
BPIDAGO:0022408negative regulation of cell-cell adhesion
BPIDAGO:0030214hyaluronan catabolic process
BPIEAGO:0030279negative regulation of ossification
BPIDAGO:0030308negative regulation of cell growth
BPIEAGO:0030316osteoclast differentiation
BPTASGO:0030334regulation of cell migration
BPIDAGO:0030335positive regulation of cell migration
BPIMPGO:0030335positive regulation of cell migration
BPIEPGO:0030501positive regulation of bone mineralization
BPTASGO:0030512negative regulation of transforming growth factor beta receptor signaling pathway
BPIEAGO:0031065positive regulation of histone deacetylation
BPIDAGO:0031293membrane protein intracellular domain proteolysis
BPIDAGO:0031334positive regulation of protein complex assembly
BPIEAGO:0031536positive regulation of exit from mitosis
BPIDAGO:0031663lipopolysaccharide-mediated signaling pathway
BPIDAGO:0032270positive regulation of cellular protein metabolic process
BPIDAGO:0032355response to estradiol
BPIDAGO:0032570response to progesterone
BPIEAGO:0032667regulation of interleukin-23 production
BPIEAGO:0032700negative regulation of interleukin-17 production
BPIDAGO:0032740positive regulation of interleukin-17 production
BPIDAGO:0032801receptor catabolic process
BPIDAGO:0032930positive regulation of superoxide anion generation
BPIEAGO:0032943mononuclear cell proliferation
BPIDAGO:0032967positive regulation of collagen biosynthetic process
BPIGIGO:0032967positive regulation of collagen biosynthetic process
BPIMPGO:0032967positive regulation of collagen biosynthetic process
BPIDAGO:0033138positive regulation of peptidyl-serine phosphorylation
BPIEAGO:0033280response to vitamin D
BPIEAGO:0034616response to laminar fluid shear stress
BPIEAGO:0035066positive regulation of histone acetylation
BPIDAGO:0035307positive regulation of protein dephosphorylation
BPIEAGO:0035902response to immobilization stress
BPIBAGO:0042127regulation of cell proliferation
BPIEAGO:0042130negative regulation of T cell proliferation
BPISSGO:0042306regulation of protein import into nucleus
BPIDAGO:0042307positive regulation of protein import into nucleus
BPIEAGO:0042482positive regulation of odontogenesis
BPIEAGO:0042552myelination
BPIBAGO:0042981regulation of apoptotic process
BPIEAGO:0043011myeloid dendritic cell differentiation
BPIEAGO:0043029T cell homeostasis
BPIEAGO:0043065positive regulation of apoptotic process
BPIDAGO:0043117positive regulation of vascular permeability
BPIDAGO:0043406positive regulation of MAP kinase activity
BPIBAGO:0043408regulation of MAPK cascade
BPIMPGO:0043491protein kinase B signaling
BPIDAGO:0043536positive regulation of blood vessel endothelial cell migration
BPIDAGO:0043537negative regulation of blood vessel endothelial cell migration
BPIDAGO:0043552positive regulation of phosphatidylinositol 3-kinase activity
BPIEPGO:0043932ossification involved in bone remodeling
BPIEAGO:0045066regulatory T cell differentiation
BPIDAGO:0045216cell-cell junction organization
BPIEAGO:0045591positive regulation of regulatory T cell differentiation
BPIEPGO:0045596negative regulation of cell differentiation
BPIDAGO:0045599negative regulation of fat cell differentiation
BPIDAGO:0045662negative regulation of myoblast differentiation
BPIDAGO:0045786negative regulation of cell cycle
BPIDAGO:0045892negative regulation of transcription, DNA-templated
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPISSGO:0045893positive regulation of transcription, DNA-templated
BPIDAGO:0045930negative regulation of mitotic cell cycle
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0048146positive regulation of fibroblast proliferation
BPIDAGO:0048298positive regulation of isotype switching to IgA isotypes
BPIBAGO:0048468cell development
BPISSGO:0048535lymph node development
BPIEAGO:0048565digestive tract development
BPIDAGO:0048642negative regulation of skeletal muscle tissue development
BPIEAGO:0048839inner ear development
BPIEAGO:0050679positive regulation of epithelial cell proliferation
BPIDAGO:0050680negative regulation of epithelial cell proliferation
BPIMPGO:0050680negative regulation of epithelial cell proliferation
BPIDAGO:0050714positive regulation of protein secretion
BPIDAGO:0050731positive regulation of peptidyl-tyrosine phosphorylation
BPIEAGO:0050765negative regulation of phagocytosis
BPTASGO:0050900leukocyte migration
BPIDAGO:0050921positive regulation of chemotaxis
BPIEAGO:0051092positive regulation of NF-kappaB transcription factor activity
BPISSGO:0051098regulation of binding
BPISSGO:0051101regulation of DNA binding
BPIEAGO:0051152positive regulation of smooth muscle cell differentiation
BPIEAGO:0051280negative regulation of release of sequestered calcium ion into cytosol
BPIEAGO:0051781positive regulation of cell division
BPIDAGO:0051897positive regulation of protein kinase B signaling
BPISSGO:0055010ventricular cardiac muscle tissue morphogenesis
BPICGO:0060312regulation of blood vessel remodeling
BPNASGO:0060312regulation of blood vessel remodeling
BPIEAGO:0060325face morphogenesis
BPIEAGO:0060364frontal suture morphogenesis
BPIDAGO:0060389pathway-restricted SMAD protein phosphorylation
BPIDAGO:0060390regulation of SMAD protein signal transduction
BPIDAGO:0060391positive regulation of SMAD protein signal transduction
BPIBAGO:0060395SMAD protein signal transduction
BPIEAGO:0060744mammary gland branching involved in thelarche
BPIEAGO:0060751branch elongation involved in mammary gland duct branching
BPIEAGO:0060762regulation of branching involved in mammary gland duct morphogenesis
BPIGIGO:0060965negative regulation of gene silencing by miRNA
BPIEAGO:0061035regulation of cartilage development
BPIDAGO:0070168negative regulation of biomineral tissue development
BPIEAGO:0070306lens fiber cell differentiation
BPIDAGO:0070374positive regulation of ERK1 and ERK2 cascade
BPIDAGO:0070723response to cholesterol
BPIEAGO:0071158positive regulation of cell cycle arrest
BPIEAGO:0071260cellular response to mechanical stimulus
BPIDAGO:0071407cellular response to organic cyclic compound
BPIEAGO:0071479cellular response to ionizing radiation
BPIEAGO:0071549cellular response to dexamethasone stimulus
BPIDAGO:0071560cellular response to transforming growth factor beta stimulus
BPIGIGO:0071560cellular response to transforming growth factor beta stimulus
BPIEAGO:0071677positive regulation of mononuclear cell migration
BPIDAGO:0085029extracellular matrix assembly
BPIEAGO:0090190positive regulation of branching involved in ureteric bud morphogenesis
BPIDAGO:0097191extrinsic apoptotic signaling pathway
BPIEAGO:0097421liver regeneration
BPIDAGO:1900126negative regulation of hyaluronan biosynthetic process
BPIDAGO:1900182positive regulation of protein localization to nucleus
BPICGO:1901203positive regulation of extracellular matrix assembly
BPIDAGO:1901666positive regulation of NAD+ ADP-ribosyltransferase activity
BPIEAGO:1902074response to salt
BPIMPGO:1902893regulation of pri-miRNA transcription by RNA polymerase II
BPIDAGO:1902895positive regulation of pri-miRNA transcription by RNA polymerase II
BPIDAGO:1903077negative regulation of protein localization to plasma membrane
BPIGIGO:1903799negative regulation of production of miRNAs involved in gene silencing by miRNA
BPIDAGO:1903800positive regulation of production of miRNAs involved in gene silencing by miRNA
BPIEAGO:1903911positive regulation of receptor clustering
BPISSGO:1905005regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
BPISSGO:1905313transforming growth factor beta receptor signaling pathway involved in heart development
BPIEAGO:1990314cellular response to insulin-like growth factor stimulus
BPISSGO:1990402embryonic liver development
BPIEAGO:2000249regulation of actin cytoskeleton reorganization
BPIDAGO:2000679positive regulation of transcription regulatory region DNA binding
BPIDAGO:2000727positive regulation of cardiac muscle cell differentiation

Gene expression in normal tissue: TGFB1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TGFB1


DatabasePathway IDPathway Des.
biocartaalkpathwayalk in cardiac myocytes
biocartactcfpathwayctcf: first multivalent nuclear factor
biocartag1pathwaycell cycle: g1/s check point
biocartail1rpathwaysignal transduction through il1r
biocartanthipathwaynfkb activation by nontypeable hemophilus influenzae
biocartatgfbpathwaytgf beta signaling pathway
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-114608Platelet degranulation
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1474244Extracellular matrix organization
reactomeR-HSA-1474244Extracellular matrix organization
reactomeR-HSA-1566948Elastic fibre formation
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-168253Host Interactions with Influenza Factors
reactomeR-HSA-168254Influenza Infection
reactomeR-HSA-168256Immune System
reactomeR-HSA-168277Influenza Virus Induced Apoptosis
reactomeR-HSA-170834Signaling by TGF-beta Receptor Complex
reactomeR-HSA-170834Signaling by TGF-beta Receptor Complex
reactomeR-HSA-202733Cell surface interactions at the vascular wall
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2129379Molecules associated with elastic fibres
reactomeR-HSA-2173788Downregulation of TGF-beta receptor signaling
reactomeR-HSA-2173788Downregulation of TGF-beta receptor signaling
reactomeR-HSA-2173789TGF-beta receptor signaling activates SMADs
reactomeR-HSA-2173789TGF-beta receptor signaling activates SMADs
reactomeR-HSA-2173791TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
reactomeR-HSA-2173791TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
reactomeR-HSA-3000170Syndecan interactions
reactomeR-HSA-3000171Non-integrin membrane-ECM interactions
reactomeR-HSA-3000178ECM proteoglycans
reactomeR-HSA-3304349Loss of Function of SMAD2/3 in Cancer
reactomeR-HSA-3304351Signaling by TGF-beta Receptor Complex in Cancer
reactomeR-HSA-3304356SMAD2/3 Phosphorylation Motif Mutants in Cancer
reactomeR-HSA-3315487SMAD2/3 MH2 Domain Mutants in Cancer
reactomeR-HSA-3642278Loss of Function of TGFBR2 in Cancer
reactomeR-HSA-3642279TGFBR2 MSI Frameshift Mutants in Cancer
reactomeR-HSA-3645790TGFBR2 Kinase Domain Mutants in Cancer
reactomeR-HSA-3656532TGFBR1 KD Mutants in Cancer
reactomeR-HSA-3656534Loss of Function of TGFBR1 in Cancer
reactomeR-HSA-3656535TGFBR1 LBD Mutants in Cancer
reactomeR-HSA-381340Transcriptional regulation of white adipocyte differentiation
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5663205Infectious disease
reactomeR-HSA-5688426Deubiquitination
reactomeR-HSA-5689603UCH proteinases
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-6785807Interleukin-4 and Interleukin-13 signaling
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-76002Platelet activation, signaling and aggregation
reactomeR-HSA-76005Response to elevated platelet cytosolic Ca2+
reactomeR-HSA-8878159Transcriptional regulation by RUNX3
reactomeR-HSA-8941855RUNX3 regulates CDKN1A transcription
reactomeR-HSA-8941858Regulation of RUNX3 expression and activity
reactomeR-HSA-8951936RUNX3 regulates p14-ARF
reactomeR-HSA-9006936Signaling by TGF-beta family members
reactomeR-HSA-9006936Signaling by TGF-beta family members
wikipathwaysWP1544MicroRNAs in cardiomyocyte hypertrophy
wikipathwaysWP1559TFs Regulate miRNAs related to cardiac hypertrophy
wikipathwaysWP179Cell Cycle
wikipathwaysWP2328Allograft Rejection
wikipathwaysWP2332Interleukin-11 Signaling Pathway
wikipathwaysWP2355Corticotropin-releasing hormone signaling pathway
wikipathwaysWP236Adipogenesis
wikipathwaysWP2406Cardiac Progenitor Differentiation
wikipathwaysWP2431Spinal Cord Injury
wikipathwaysWP2572Primary Focal Segmental Glomerulosclerosis FSGS
wikipathwaysWP2795Cardiac Hypertrophic Response
wikipathwaysWP2848Differentiation Pathway
wikipathwaysWP2853Endoderm Differentiation
wikipathwaysWP2855Dopaminergic Neurogenesis
wikipathwaysWP286IL-3 Signaling Pathway
wikipathwaysWP2870Extracellular vesicle-mediated signaling in recipient cells
wikipathwaysWP2873Aryl Hydrocarbon Receptor Pathway
wikipathwaysWP2877Vitamin D Receptor Pathway
wikipathwaysWP2882Nuclear Receptors Meta-Pathway
wikipathwaysWP2884NRF2 pathway
wikipathwaysWP3624Lung fibrosis
wikipathwaysWP3646Hepatitis C and Hepatocellular Carcinoma
wikipathwaysWP366TGF-beta Signaling Pathway
wikipathwaysWP3670Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3874Canonical and Non-Canonical TGF-B signaling
wikipathwaysWP3980Protein alkylation leading to liver fibrosis
wikipathwaysWP4018Pathways in clear cell renal cell carcinoma
wikipathwaysWP4066Interleukin-4 and 13 signaling
wikipathwaysWP4216Chromosomal and microsatellite instability in colorectal cancer
wikipathwaysWP4239EMT transition in Colorectal Cancer
wikipathwaysWP4241Type 2 papillary renal cell carcinoma
wikipathwaysWP474Endochondral Ossification
wikipathwaysWP530Cytokines and Inflammatory Response
wikipathwaysWP554ACE Inhibitor Pathway
wikipathwaysWP560TGF-beta Receptor Signaling
wikipathwaysWP615Senescence and Autophagy in Cancer
wikipathwaysWP69T-Cell antigen Receptor (TCR) Signaling Pathway
wikipathwaysWP710DNA Damage Response (only ATM dependent)
pidalk1pathwayALK1 signaling events
pidap1_pathwayAP-1 transcription factor network
pidglypican_1pathwayGlypican 1 network
pidil12_stat4pathwayIL12 signaling mediated by STAT4
pidil27pathwayIL27-mediated signaling events
pidrxr_vdr_pathwayRXR and RAR heterodimerization with other nuclear receptor
pidsyndecan_1_pathwaySyndecan-1-mediated signaling events
pidsyndecan_2_pathwaySyndecan-2-mediated signaling events
pidtelomerasepathwayRegulation of Telomerase
pidtgfbrpathwayTGF-beta receptor signaling
pidupa_upar_pathwayUrokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
pharmgkbPA165110622Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics
pharmgkbPA165985892Tacrolimus/Cyclosporine Pathway, Pharmacodynamics
pharmgkbPA2023ACE Inhibitor Pathway, Pharmacodynamics
netpathPathway_TGF_beta_ReceptorTGF_beta_Receptor
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04068FoxO signaling pathway - Homo sapiens (human)
kegghsa04110Cell cycle - Homo sapiens (human)
kegghsa04218Cellular senescence - Homo sapiens (human)
kegghsa04350TGF-beta signaling pathway - Homo sapiens (human)
kegghsa04380Osteoclast differentiation - Homo sapiens (human)
kegghsa04390Hippo signaling pathway - Homo sapiens (human)
kegghsa04659Th17 cell differentiation - Homo sapiens (human)
kegghsa04672Intestinal immune network for IgA production - Homo sapiens (human)
kegghsa04926Relaxin signaling pathway - Homo sapiens (human)
kegghsa04932Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)
kegghsa04933AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
kegghsa05140Leishmaniasis - Homo sapiens (human)
kegghsa05142Chagas disease (American trypanosomiasis) - Homo sapiens (human)
kegghsa05144Malaria - Homo sapiens (human)
kegghsa05145Toxoplasmosis - Homo sapiens (human)
kegghsa05146Amoebiasis - Homo sapiens (human)
kegghsa05152Tuberculosis - Homo sapiens (human)
kegghsa05161Hepatitis B - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05205Proteoglycans in cancer - Homo sapiens (human)
kegghsa05210Colorectal cancer - Homo sapiens (human)
kegghsa05211Renal cell carcinoma - Homo sapiens (human)
kegghsa05212Pancreatic cancer - Homo sapiens (human)
kegghsa05220Chronic myeloid leukemia - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
kegghsa05226Gastric cancer - Homo sapiens (human)
kegghsa05321Inflammatory bowel disease (IBD) - Homo sapiens (human)
kegghsa05323Rheumatoid arthritis - Homo sapiens (human)
kegghsa05410Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human)
kegghsa05414Dilated cardiomyopathy (DCM) - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD396AS6012451
iGMDRD289Parthenolide3
iGMDRD105Triptolide3
iGMDRD705Nakiterpiosin6
iGMDRD251ML1626
iGMDRD264Bryostatin 11
iGMDRD245FH5351
iGMDRD329Merck602
iGMDRD200STF622471
iGMDRD871BRD63685
iGMDRD286Nsc 6328396
iGMDRD405PIK-752
iGMDRD719IOX22
iGMDRD945ML2146
iGMDRD883CIL55A5
iGMDRD1002rTRAIL2
iGMDRD123Isoevodiamine4
iGMDRD698Neratinib3
iGMDRD593CX-54612
iGMDRD507GSK6906931
iGMDRD493GSK269962A1
iGMDRD260FQI-23
iGMDRD23Gossypol5
iGMDRD64Parbendazole6
iGMDRD146Elesclomol1
iGMDRD780PP-302
iGMDRD506Fedratinib5
iGMDRD399Selumetinib1
iGMDRD188Piperlongumine10
iGMDRD397Pazopanib1
iGMDRD781Sirolimus1
iGMDRD135Lenalidomide1
iGMDRD546BMS-7548071
iGMDRD151CHM-12
iGMDRD679Bistramide A1
iGMDRD394BX-7951
iGMDRD152179324-69-71
iGMDRD504Obatoclax1
iGMDRD459RO-33061
iGMDRD353PD03259012
iGMDRD246NPC265
iGMDRD300Tozasertib2
iGMDRD544Vismodegib (GDC-0449)1
iGMDRD872BRD71373
iGMDRD125BIRB-7961
iGMDRD347Y-399831
iGMDRD486Tosedostat2
iGMDRD292NSC878771
iGMDRD30917AAG1
iGMDRD440Nutlin-3A1
iGMDRD318PAC-13
iGMDRD573GSK-1904529A1
iGMDRD700AUY9221
iGMDRD138PX 126
iGMDRD60Quinoclamine4
iGMDRD364CP-7247141
iGMDRD562Navitoclax3
iGMDRD577BIX012948
iGMDRD887Compound 23 citrate2
iGMDRD332A-7700411
iGMDRD129SB-2167631
iGMDRD144NSC953979
iGMDRD678Tubastatin A2
iGMDRD599Salermide2
iGMDRD387CHIR-990212
iGMDRD3615Z-7-Oxozeaenol1
iGMDRD634SCHEMBL26080412
iGMDRD280CYTOCHALASIN B3
iGMDRD297Austocystin D3
iGMDRD193Fqi16
iGMDRD66Doxorubicin1
iGMDRD608Refametinib1
iGMDRD446LY 21832406

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TGFB1

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