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TGFB1

Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease. [provided by RefSeq, Aug 2016].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
transforming growth factor beta 1	MIM:190180	Ensembl:ENSG00000105329	HGNC:HGNC:11766	PA350	19q13.2

Gene Categories:

TUMOR SUPPRESSOR KINASE CELL SURFACE LIPID KINASE DRUG RESISTANCE SERINE THREONINE KINASE HISTONE MODIFICATION DRUGGABLE GENOME GROWTH FACTOR

GO terms in TGFB1

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IPI	GO:0003823	antigen binding
MF	IBA	GO:0005114	type II transforming growth factor beta receptor binding
MF	IDA	GO:0005114	type II transforming growth factor beta receptor binding
MF	IMP	GO:0005114	type II transforming growth factor beta receptor binding
MF	IPI	GO:0005114	type II transforming growth factor beta receptor binding
MF	IBA	GO:0005125	cytokine activity
MF	TAS	GO:0005125	cytokine activity
MF	IBA	GO:0005160	transforming growth factor beta receptor binding
MF	TAS	GO:0005160	transforming growth factor beta receptor binding
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0008083	growth factor activity
MF	IPI	GO:0019899	enzyme binding
MF	IMP	GO:0034713	type I transforming growth factor beta receptor binding
MF	IPI	GO:0034713	type I transforming growth factor beta receptor binding
MF	IMP	GO:0034714	type III transforming growth factor beta receptor binding
MF	IPI	GO:0034714	type III transforming growth factor beta receptor binding
MF	IPI	GO:0042802	identical protein binding
MF	IEA	GO:0042803	protein homodimerization activity
MF	IEA	GO:0043539	protein serine/threonine kinase activator activity
MF	IEA	GO:0046982	protein heterodimerization activity
MF	IEA	GO:0047485	protein N-terminus binding
CC	TAS	GO:0005576	extracellular region
CC	IBA	GO:0005615	extracellular space
CC	IDA	GO:0005615	extracellular space
CC	IDA	GO:0005634	nucleus
CC	IDA	GO:0005737	cytoplasm
CC	TAS	GO:0005796	Golgi lumen
CC	TAS	GO:0005886	plasma membrane
CC	IDA	GO:0005902	microvillus
CC	IMP	GO:0009986	cell surface
CC	IEA	GO:0030424	axon
CC	ISS	GO:0031012	extracellular matrix
CC	TAS	GO:0031093	platelet alpha granule lumen
CC	IEA	GO:0043025	neuronal cell body
CC	HDA	GO:0062023	collagen-containing extracellular matrix
CC	HDA	GO:0072562	blood microparticle
BP	IDA	GO:0000060	protein import into nucleus, translocation
BP	IEA	GO:0000122	negative regulation of transcription by RNA polymerase II
BP	IMP	GO:0000165	MAPK cascade
BP	ISS	GO:0001570	vasculogenesis
BP	IEA	GO:0001657	ureteric bud development
BP	IEA	GO:0001666	response to hypoxia
BP	IDA	GO:0001837	epithelial to mesenchymal transition
BP	ISS	GO:0001843	neural tube closure
BP	IDA	GO:0001933	negative regulation of protein phosphorylation
BP	IDA	GO:0001934	positive regulation of protein phosphorylation
BP	IEA	GO:0002028	regulation of sodium ion transport
BP	IDA	GO:0002062	chondrocyte differentiation
BP	IDA	GO:0002244	hematopoietic progenitor cell differentiation
BP	TAS	GO:0002248	connective tissue replacement involved in inflammatory response wound healing
BP	IEA	GO:0002460	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
BP	IEA	GO:0002513	tolerance induction to self antigen
BP	TAS	GO:0002576	platelet degranulation
BP	ISS	GO:0003179	heart valve morphogenesis
BP	ISS	GO:0006468	protein phosphorylation
BP	IDA	GO:0006611	protein export from nucleus
BP	IDA	GO:0006754	ATP biosynthetic process
BP	IDA	GO:0006796	phosphate-containing compound metabolic process
BP	IEA	GO:0006874	cellular calcium ion homeostasis
BP	IDA	GO:0006954	inflammatory response
BP	IDA	GO:0007050	cell cycle arrest
BP	IDA	GO:0007093	mitotic cell cycle checkpoint
BP	IDA	GO:0007173	epidermal growth factor receptor signaling pathway
BP	IBA	GO:0007179	transforming growth factor beta receptor signaling pathway
BP	IDA	GO:0007179	transforming growth factor beta receptor signaling pathway
BP	TAS	GO:0007179	transforming growth factor beta receptor signaling pathway
BP	IDA	GO:0007182	common-partner SMAD protein phosphorylation
BP	IDA	GO:0007183	SMAD protein complex assembly
BP	IEA	GO:0007219	Notch signaling pathway
BP	IEA	GO:0007406	negative regulation of neuroblast proliferation
BP	IEP	GO:0007435	salivary gland morphogenesis
BP	IEA	GO:0007492	endoderm development
BP	ISS	GO:0007507	heart development
BP	IEA	GO:0007565	female pregnancy
BP	IEA	GO:0007568	aging
BP	IDA	GO:0008284	positive regulation of cell proliferation
BP	IMP	GO:0008284	positive regulation of cell proliferation
BP	IDA	GO:0008285	negative regulation of cell proliferation
BP	IMP	GO:0008285	negative regulation of cell proliferation
BP	IEA	GO:0008354	germ cell migration
BP	IEP	GO:0009611	response to wounding
BP	IEA	GO:0009749	response to glucose
BP	IEA	GO:0009817	defense response to fungus, incompatible interaction
BP	IEA	GO:0010469	regulation of signaling receptor activity
BP	TAS	GO:0010575	positive regulation of vascular endothelial growth factor production
BP	IDA	GO:0010628	positive regulation of gene expression
BP	IGI	GO:0010628	positive regulation of gene expression
BP	IMP	GO:0010628	positive regulation of gene expression
BP	ISS	GO:0010628	positive regulation of gene expression
BP	IDA	GO:0010629	negative regulation of gene expression
BP	IGI	GO:0010629	negative regulation of gene expression
BP	ISS	GO:0010629	negative regulation of gene expression
BP	IC	GO:0010716	negative regulation of extracellular matrix disassembly
BP	IDA	GO:0010718	positive regulation of epithelial to mesenchymal transition
BP	NAS	GO:0010718	positive regulation of epithelial to mesenchymal transition
BP	IC	GO:0010742	macrophage derived foam cell differentiation
BP	IDA	GO:0010763	positive regulation of fibroblast migration
BP	IDA	GO:0010800	positive regulation of peptidyl-threonine phosphorylation
BP	IBA	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
BP	IDA	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
BP	IDA	GO:0010936	negative regulation of macrophage cytokine production
BP	IEA	GO:0014003	oligodendrocyte development
BP	ISS	GO:0016202	regulation of striated muscle tissue development
BP	IDA	GO:0016477	cell migration
BP	IDA	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway
BP	IDA	GO:0019049	evasion or tolerance of host defenses by virus
BP	TAS	GO:0019221	cytokine-mediated signaling pathway
BP	ISS	GO:0021915	neural tube development
BP	IDA	GO:0022408	negative regulation of cell-cell adhesion
BP	IDA	GO:0030214	hyaluronan catabolic process
BP	IEA	GO:0030279	negative regulation of ossification
BP	IDA	GO:0030308	negative regulation of cell growth
BP	IEA	GO:0030316	osteoclast differentiation
BP	TAS	GO:0030334	regulation of cell migration
BP	IDA	GO:0030335	positive regulation of cell migration
BP	IMP	GO:0030335	positive regulation of cell migration
BP	IEP	GO:0030501	positive regulation of bone mineralization
BP	TAS	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
BP	IEA	GO:0031065	positive regulation of histone deacetylation
BP	IDA	GO:0031293	membrane protein intracellular domain proteolysis
BP	IDA	GO:0031334	positive regulation of protein complex assembly
BP	IEA	GO:0031536	positive regulation of exit from mitosis
BP	IDA	GO:0031663	lipopolysaccharide-mediated signaling pathway
BP	IDA	GO:0032270	positive regulation of cellular protein metabolic process
BP	IDA	GO:0032355	response to estradiol
BP	IDA	GO:0032570	response to progesterone
BP	IEA	GO:0032667	regulation of interleukin-23 production
BP	IEA	GO:0032700	negative regulation of interleukin-17 production
BP	IDA	GO:0032740	positive regulation of interleukin-17 production
BP	IDA	GO:0032801	receptor catabolic process
BP	IDA	GO:0032930	positive regulation of superoxide anion generation
BP	IEA	GO:0032943	mononuclear cell proliferation
BP	IDA	GO:0032967	positive regulation of collagen biosynthetic process
BP	IGI	GO:0032967	positive regulation of collagen biosynthetic process
BP	IMP	GO:0032967	positive regulation of collagen biosynthetic process
BP	IDA	GO:0033138	positive regulation of peptidyl-serine phosphorylation
BP	IEA	GO:0033280	response to vitamin D
BP	IEA	GO:0034616	response to laminar fluid shear stress
BP	IEA	GO:0035066	positive regulation of histone acetylation
BP	IDA	GO:0035307	positive regulation of protein dephosphorylation
BP	IEA	GO:0035902	response to immobilization stress
BP	IBA	GO:0042127	regulation of cell proliferation
BP	IEA	GO:0042130	negative regulation of T cell proliferation
BP	ISS	GO:0042306	regulation of protein import into nucleus
BP	IDA	GO:0042307	positive regulation of protein import into nucleus
BP	IEA	GO:0042482	positive regulation of odontogenesis
BP	IEA	GO:0042552	myelination
BP	IBA	GO:0042981	regulation of apoptotic process
BP	IEA	GO:0043011	myeloid dendritic cell differentiation
BP	IEA	GO:0043029	T cell homeostasis
BP	IEA	GO:0043065	positive regulation of apoptotic process
BP	IDA	GO:0043117	positive regulation of vascular permeability
BP	IDA	GO:0043406	positive regulation of MAP kinase activity
BP	IBA	GO:0043408	regulation of MAPK cascade
BP	IMP	GO:0043491	protein kinase B signaling
BP	IDA	GO:0043536	positive regulation of blood vessel endothelial cell migration
BP	IDA	GO:0043537	negative regulation of blood vessel endothelial cell migration
BP	IDA	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
BP	IEP	GO:0043932	ossification involved in bone remodeling
BP	IEA	GO:0045066	regulatory T cell differentiation
BP	IDA	GO:0045216	cell-cell junction organization
BP	IEA	GO:0045591	positive regulation of regulatory T cell differentiation
BP	IEP	GO:0045596	negative regulation of cell differentiation
BP	IDA	GO:0045599	negative regulation of fat cell differentiation
BP	IDA	GO:0045662	negative regulation of myoblast differentiation
BP	IDA	GO:0045786	negative regulation of cell cycle
BP	IDA	GO:0045892	negative regulation of transcription, DNA-templated
BP	IDA	GO:0045893	positive regulation of transcription, DNA-templated
BP	ISS	GO:0045893	positive regulation of transcription, DNA-templated
BP	IDA	GO:0045930	negative regulation of mitotic cell cycle
BP	IDA	GO:0045944	positive regulation of transcription by RNA polymerase II
BP	IEA	GO:0048146	positive regulation of fibroblast proliferation
BP	IDA	GO:0048298	positive regulation of isotype switching to IgA isotypes
BP	IBA	GO:0048468	cell development
BP	ISS	GO:0048535	lymph node development
BP	IEA	GO:0048565	digestive tract development
BP	IDA	GO:0048642	negative regulation of skeletal muscle tissue development
BP	IEA	GO:0048839	inner ear development
BP	IEA	GO:0050679	positive regulation of epithelial cell proliferation
BP	IDA	GO:0050680	negative regulation of epithelial cell proliferation
BP	IMP	GO:0050680	negative regulation of epithelial cell proliferation
BP	IDA	GO:0050714	positive regulation of protein secretion
BP	IDA	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
BP	IEA	GO:0050765	negative regulation of phagocytosis
BP	TAS	GO:0050900	leukocyte migration
BP	IDA	GO:0050921	positive regulation of chemotaxis
BP	IEA	GO:0051092	positive regulation of NF-kappaB transcription factor activity
BP	ISS	GO:0051098	regulation of binding
BP	ISS	GO:0051101	regulation of DNA binding
BP	IEA	GO:0051152	positive regulation of smooth muscle cell differentiation
BP	IEA	GO:0051280	negative regulation of release of sequestered calcium ion into cytosol
BP	IEA	GO:0051781	positive regulation of cell division
BP	IDA	GO:0051897	positive regulation of protein kinase B signaling
BP	ISS	GO:0055010	ventricular cardiac muscle tissue morphogenesis
BP	IC	GO:0060312	regulation of blood vessel remodeling
BP	NAS	GO:0060312	regulation of blood vessel remodeling
BP	IEA	GO:0060325	face morphogenesis
BP	IEA	GO:0060364	frontal suture morphogenesis
BP	IDA	GO:0060389	pathway-restricted SMAD protein phosphorylation
BP	IDA	GO:0060390	regulation of SMAD protein signal transduction
BP	IDA	GO:0060391	positive regulation of SMAD protein signal transduction
BP	IBA	GO:0060395	SMAD protein signal transduction
BP	IEA	GO:0060744	mammary gland branching involved in thelarche
BP	IEA	GO:0060751	branch elongation involved in mammary gland duct branching
BP	IEA	GO:0060762	regulation of branching involved in mammary gland duct morphogenesis
BP	IGI	GO:0060965	negative regulation of gene silencing by miRNA
BP	IEA	GO:0061035	regulation of cartilage development
BP	IDA	GO:0070168	negative regulation of biomineral tissue development
BP	IEA	GO:0070306	lens fiber cell differentiation
BP	IDA	GO:0070374	positive regulation of ERK1 and ERK2 cascade
BP	IDA	GO:0070723	response to cholesterol
BP	IEA	GO:0071158	positive regulation of cell cycle arrest
BP	IEA	GO:0071260	cellular response to mechanical stimulus
BP	IDA	GO:0071407	cellular response to organic cyclic compound
BP	IEA	GO:0071479	cellular response to ionizing radiation
BP	IEA	GO:0071549	cellular response to dexamethasone stimulus
BP	IDA	GO:0071560	cellular response to transforming growth factor beta stimulus
BP	IGI	GO:0071560	cellular response to transforming growth factor beta stimulus
BP	IEA	GO:0071677	positive regulation of mononuclear cell migration
BP	IDA	GO:0085029	extracellular matrix assembly
BP	IEA	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis
BP	IDA	GO:0097191	extrinsic apoptotic signaling pathway
BP	IEA	GO:0097421	liver regeneration
BP	IDA	GO:1900126	negative regulation of hyaluronan biosynthetic process
BP	IDA	GO:1900182	positive regulation of protein localization to nucleus
BP	IC	GO:1901203	positive regulation of extracellular matrix assembly
BP	IDA	GO:1901666	positive regulation of NAD+ ADP-ribosyltransferase activity
BP	IEA	GO:1902074	response to salt
BP	IMP	GO:1902893	regulation of pri-miRNA transcription by RNA polymerase II
BP	IDA	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II
BP	IDA	GO:1903077	negative regulation of protein localization to plasma membrane
BP	IGI	GO:1903799	negative regulation of production of miRNAs involved in gene silencing by miRNA
BP	IDA	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA
BP	IEA	GO:1903911	positive regulation of receptor clustering
BP	ISS	GO:1905005	regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
BP	ISS	GO:1905313	transforming growth factor beta receptor signaling pathway involved in heart development
BP	IEA	GO:1990314	cellular response to insulin-like growth factor stimulus
BP	ISS	GO:1990402	embryonic liver development
BP	IEA	GO:2000249	regulation of actin cytoskeleton reorganization
BP	IDA	GO:2000679	positive regulation of transcription regulatory region DNA binding
BP	IDA	GO:2000727	positive regulation of cardiac muscle cell differentiation

Gene expression in normal tissue: TGFB1

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TGFB1

Database	Pathway ID	Pathway Des.
biocarta	alkpathway	alk in cardiac myocytes
biocarta	ctcfpathway	ctcf: first multivalent nuclear factor
biocarta	g1pathway	cell cycle: g1/s check point
biocarta	il1rpathway	signal transduction through il1r
biocarta	nthipathway	nfkb activation by nontypeable hemophilus influenzae
biocarta	tgfbpathway	tgf beta signaling pathway
reactome	R-HSA-109582	Hemostasis
reactome	R-HSA-114608	Platelet degranulation
reactome	R-HSA-1266738	Developmental Biology
reactome	R-HSA-1280215	Cytokine Signaling in Immune system
reactome	R-HSA-1474244	Extracellular matrix organization
reactome	R-HSA-1474244	Extracellular matrix organization
reactome	R-HSA-1566948	Elastic fibre formation
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-1643685	Disease
reactome	R-HSA-168253	Host Interactions with Influenza Factors
reactome	R-HSA-168254	Influenza Infection
reactome	R-HSA-168256	Immune System
reactome	R-HSA-168277	Influenza Virus Induced Apoptosis
reactome	R-HSA-170834	Signaling by TGF-beta Receptor Complex
reactome	R-HSA-170834	Signaling by TGF-beta Receptor Complex
reactome	R-HSA-202733	Cell surface interactions at the vascular wall
reactome	R-HSA-212436	Generic Transcription Pathway
reactome	R-HSA-2129379	Molecules associated with elastic fibres
reactome	R-HSA-2173788	Downregulation of TGF-beta receptor signaling
reactome	R-HSA-2173788	Downregulation of TGF-beta receptor signaling
reactome	R-HSA-2173789	TGF-beta receptor signaling activates SMADs
reactome	R-HSA-2173789	TGF-beta receptor signaling activates SMADs
reactome	R-HSA-2173791	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
reactome	R-HSA-2173791	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
reactome	R-HSA-3000170	Syndecan interactions
reactome	R-HSA-3000171	Non-integrin membrane-ECM interactions
reactome	R-HSA-3000178	ECM proteoglycans
reactome	R-HSA-3304349	Loss of Function of SMAD2/3 in Cancer
reactome	R-HSA-3304351	Signaling by TGF-beta Receptor Complex in Cancer
reactome	R-HSA-3304356	SMAD2/3 Phosphorylation Motif Mutants in Cancer
reactome	R-HSA-3315487	SMAD2/3 MH2 Domain Mutants in Cancer
reactome	R-HSA-3642278	Loss of Function of TGFBR2 in Cancer
reactome	R-HSA-3642279	TGFBR2 MSI Frameshift Mutants in Cancer
reactome	R-HSA-3645790	TGFBR2 Kinase Domain Mutants in Cancer
reactome	R-HSA-3656532	TGFBR1 KD Mutants in Cancer
reactome	R-HSA-3656534	Loss of Function of TGFBR1 in Cancer
reactome	R-HSA-3656535	TGFBR1 LBD Mutants in Cancer
reactome	R-HSA-381340	Transcriptional regulation of white adipocyte differentiation
reactome	R-HSA-392499	Metabolism of proteins
reactome	R-HSA-449147	Signaling by Interleukins
reactome	R-HSA-5663202	Diseases of signal transduction
reactome	R-HSA-5663205	Infectious disease
reactome	R-HSA-5688426	Deubiquitination
reactome	R-HSA-5689603	UCH proteinases
reactome	R-HSA-597592	Post-translational protein modification
reactome	R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling
reactome	R-HSA-73857	RNA Polymerase II Transcription
reactome	R-HSA-74160	Gene expression (Transcription)
reactome	R-HSA-76002	Platelet activation, signaling and aggregation
reactome	R-HSA-76005	Response to elevated platelet cytosolic Ca2+
reactome	R-HSA-8878159	Transcriptional regulation by RUNX3
reactome	R-HSA-8941855	RUNX3 regulates CDKN1A transcription
reactome	R-HSA-8941858	Regulation of RUNX3 expression and activity
reactome	R-HSA-8951936	RUNX3 regulates p14-ARF
reactome	R-HSA-9006936	Signaling by TGF-beta family members
reactome	R-HSA-9006936	Signaling by TGF-beta family members
wikipathways	WP1544	MicroRNAs in cardiomyocyte hypertrophy
wikipathways	WP1559	TFs Regulate miRNAs related to cardiac hypertrophy
wikipathways	WP179	Cell Cycle
wikipathways	WP2328	Allograft Rejection
wikipathways	WP2332	Interleukin-11 Signaling Pathway
wikipathways	WP2355	Corticotropin-releasing hormone signaling pathway
wikipathways	WP236	Adipogenesis
wikipathways	WP2406	Cardiac Progenitor Differentiation
wikipathways	WP2431	Spinal Cord Injury
wikipathways	WP2572	Primary Focal Segmental Glomerulosclerosis FSGS
wikipathways	WP2795	Cardiac Hypertrophic Response
wikipathways	WP2848	Differentiation Pathway
wikipathways	WP2853	Endoderm Differentiation
wikipathways	WP2855	Dopaminergic Neurogenesis
wikipathways	WP286	IL-3 Signaling Pathway
wikipathways	WP2870	Extracellular vesicle-mediated signaling in recipient cells
wikipathways	WP2873	Aryl Hydrocarbon Receptor Pathway
wikipathways	WP2877	Vitamin D Receptor Pathway
wikipathways	WP2882	Nuclear Receptors Meta-Pathway
wikipathways	WP2884	NRF2 pathway
wikipathways	WP3624	Lung fibrosis
wikipathways	WP3646	Hepatitis C and Hepatocellular Carcinoma
wikipathways	WP366	TGF-beta Signaling Pathway
wikipathways	WP3670	Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway
wikipathways	WP382	MAPK Signaling Pathway
wikipathways	WP3874	Canonical and Non-Canonical TGF-B signaling
wikipathways	WP3980	Protein alkylation leading to liver fibrosis
wikipathways	WP4018	Pathways in clear cell renal cell carcinoma
wikipathways	WP4066	Interleukin-4 and 13 signaling
wikipathways	WP4216	Chromosomal and microsatellite instability in colorectal cancer
wikipathways	WP4239	EMT transition in Colorectal Cancer
wikipathways	WP4241	Type 2 papillary renal cell carcinoma
wikipathways	WP474	Endochondral Ossification
wikipathways	WP530	Cytokines and Inflammatory Response
wikipathways	WP554	ACE Inhibitor Pathway
wikipathways	WP560	TGF-beta Receptor Signaling
wikipathways	WP615	Senescence and Autophagy in Cancer
wikipathways	WP69	T-Cell antigen Receptor (TCR) Signaling Pathway
wikipathways	WP710	DNA Damage Response (only ATM dependent)
pid	alk1pathway	ALK1 signaling events
pid	ap1_pathway	AP-1 transcription factor network
pid	glypican_1pathway	Glypican 1 network
pid	il12_stat4pathway	IL12 signaling mediated by STAT4
pid	il27pathway	IL27-mediated signaling events
pid	rxr_vdr_pathway	RXR and RAR heterodimerization with other nuclear receptor
pid	syndecan_1_pathway	Syndecan-1-mediated signaling events
pid	syndecan_2_pathway	Syndecan-2-mediated signaling events
pid	telomerasepathway	Regulation of Telomerase
pid	tgfbrpathway	TGF-beta receptor signaling
pid	upa_upar_pathway	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
pharmgkb	PA165110622	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics
pharmgkb	PA165985892	Tacrolimus/Cyclosporine Pathway, Pharmacodynamics
pharmgkb	PA2023	ACE Inhibitor Pathway, Pharmacodynamics
netpath	Pathway_TGF_beta_Receptor	TGF_beta_Receptor
kegg	hsa04010	MAPK signaling pathway - Homo sapiens (human)
kegg	hsa04060	Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegg	hsa04068	FoxO signaling pathway - Homo sapiens (human)
kegg	hsa04110	Cell cycle - Homo sapiens (human)
kegg	hsa04218	Cellular senescence - Homo sapiens (human)
kegg	hsa04350	TGF-beta signaling pathway - Homo sapiens (human)
kegg	hsa04380	Osteoclast differentiation - Homo sapiens (human)
kegg	hsa04390	Hippo signaling pathway - Homo sapiens (human)
kegg	hsa04659	Th17 cell differentiation - Homo sapiens (human)
kegg	hsa04672	Intestinal immune network for IgA production - Homo sapiens (human)
kegg	hsa04926	Relaxin signaling pathway - Homo sapiens (human)
kegg	hsa04932	Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)
kegg	hsa04933	AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
kegg	hsa05140	Leishmaniasis - Homo sapiens (human)
kegg	hsa05142	Chagas disease (American trypanosomiasis) - Homo sapiens (human)
kegg	hsa05144	Malaria - Homo sapiens (human)
kegg	hsa05145	Toxoplasmosis - Homo sapiens (human)
kegg	hsa05146	Amoebiasis - Homo sapiens (human)
kegg	hsa05152	Tuberculosis - Homo sapiens (human)
kegg	hsa05161	Hepatitis B - Homo sapiens (human)
kegg	hsa05166	HTLV-I infection - Homo sapiens (human)
kegg	hsa05200	Pathways in cancer - Homo sapiens (human)
kegg	hsa05205	Proteoglycans in cancer - Homo sapiens (human)
kegg	hsa05210	Colorectal cancer - Homo sapiens (human)
kegg	hsa05211	Renal cell carcinoma - Homo sapiens (human)
kegg	hsa05212	Pancreatic cancer - Homo sapiens (human)
kegg	hsa05220	Chronic myeloid leukemia - Homo sapiens (human)
kegg	hsa05225	Hepatocellular carcinoma - Homo sapiens (human)
kegg	hsa05226	Gastric cancer - Homo sapiens (human)
kegg	hsa05321	Inflammatory bowel disease (IBD) - Homo sapiens (human)
kegg	hsa05323	Rheumatoid arthritis - Homo sapiens (human)
kegg	hsa05410	Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human)
kegg	hsa05414	Dilated cardiomyopathy (DCM) - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD396	AS601245	1
iGMDRD289	Parthenolide	3
iGMDRD105	Triptolide	3
iGMDRD705	Nakiterpiosin	6
iGMDRD251	ML162	6
iGMDRD264	Bryostatin 1	1
iGMDRD245	FH535	1
iGMDRD329	Merck60	2
iGMDRD200	STF62247	1
iGMDRD871	BRD6368	5
iGMDRD286	Nsc 632839	6
iGMDRD405	PIK-75	2
iGMDRD719	IOX2	2
iGMDRD945	ML214	6
iGMDRD883	CIL55A	5
iGMDRD1002	rTRAIL	2
iGMDRD123	Isoevodiamine	4
iGMDRD698	Neratinib	3
iGMDRD593	CX-5461	2
iGMDRD507	GSK690693	1
iGMDRD493	GSK269962A	1
iGMDRD260	FQI-2	3
iGMDRD23	Gossypol	5
iGMDRD64	Parbendazole	6
iGMDRD146	Elesclomol	1
iGMDRD780	PP-30	2
iGMDRD506	Fedratinib	5
iGMDRD399	Selumetinib	1
iGMDRD188	Piperlongumine	10
iGMDRD397	Pazopanib	1
iGMDRD781	Sirolimus	1
iGMDRD135	Lenalidomide	1
iGMDRD546	BMS-754807	1
iGMDRD151	CHM-1	2
iGMDRD679	Bistramide A	1
iGMDRD394	BX-795	1
iGMDRD152	179324-69-7	1
iGMDRD504	Obatoclax	1
iGMDRD459	RO-3306	1
iGMDRD353	PD0325901	2
iGMDRD246	NPC26	5
iGMDRD300	Tozasertib	2
iGMDRD544	Vismodegib (GDC-0449)	1
iGMDRD872	BRD7137	3
iGMDRD125	BIRB-796	1
iGMDRD347	Y-39983	1
iGMDRD486	Tosedostat	2
iGMDRD292	NSC87877	1
iGMDRD309	17AAG	1
iGMDRD440	Nutlin-3A	1
iGMDRD318	PAC-1	3
iGMDRD573	GSK-1904529A	1
iGMDRD700	AUY922	1
iGMDRD138	PX 12	6
iGMDRD60	Quinoclamine	4
iGMDRD364	CP-724714	1
iGMDRD562	Navitoclax	3
iGMDRD577	BIX01294	8
iGMDRD887	Compound 23 citrate	2
iGMDRD332	A-770041	1
iGMDRD129	SB-216763	1
iGMDRD144	NSC95397	9
iGMDRD678	Tubastatin A	2
iGMDRD599	Salermide	2
iGMDRD387	CHIR-99021	2
iGMDRD361	5Z-7-Oxozeaenol	1
iGMDRD634	SCHEMBL2608041	2
iGMDRD280	CYTOCHALASIN B	3
iGMDRD297	Austocystin D	3
iGMDRD193	Fqi1	6
iGMDRD66	Doxorubicin	1
iGMDRD608	Refametinib	1
iGMDRD446	LY 2183240	6

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TGFB1

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.