iGMDRD440

Canonical SMILES: CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl

InChI: InChI=1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)/t27-,28+/m0/s1

InChI Key: BDUHCSBCVGXTJM-WUFINQPMSA-N

Standard NameCHEMBLPubchem CIDDrug StatusDrug Type
Nutlin-3ACHEMBL191334 11433200AloneSmall Molecule

Drug Targets:

MDM2

Drug Pathways:

p53 pathway

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot


Gene IDGene NameModel Num.
3845KRAS1
8289ARID1A1
6597SMARCA41
6598SMARCB11
288ANK31
834CASP11
6416MAP2K41
1029CDKN2A2
7157TP5321
2322FLT31
8923202COX21
673BRAF1
2067ERCC11
5925RB11
7040TGFB11
581BAX1
595CCND11
4613MYCN1
1499CTNNB14

Gene in drug-gene network: Network Plot

Models in Nutlin-3A

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