BAX
Summary: The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:600040 Ensembl IDEnsembl:ENSG00000087088 HGNC IDHGNC:HGNC:959 PHARMGKB IDPA25269 Map Location19q13.33 | |||||
GO terms in BAX
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008289 | lipid binding |
| MF | IBA | GO:0015267 | channel activity |
| MF | IDA | GO:0015267 | channel activity |
| MF | IEA | GO:0030544 | Hsp70 protein binding |
| MF | IPI | GO:0042802 | identical protein binding |
Gene expression in normal tissue: BAX
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BAX
Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | badpathway | regulation of bad phosphorylation |
| biocarta | ceramidepathway | ceramide signaling pathway |
| biocarta | chemicalpathway | apoptotic signaling in response to dna damage |
| biocarta | mitochondriapathway | role of mitochondria in apoptotic signaling |
| biocarta | p53hypoxiapathway | hypoxia and p53 in the cardiovascular system |
| biocarta | plk3pathway | regulation of cell cycle progression by plk3 |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BAX
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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