Summary: The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq, Jul 2008].

BCL2 associated X, apoptosis regulatorMIM:600040Ensembl:ENSG00000087088HGNC:HGNC:959PA2526919q13.33

GO terms in BAX

Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
MFIDAGO:0008289lipid binding
MFIBAGO:0015267channel activity
MFIDAGO:0015267channel activity
MFIEAGO:0030544Hsp70 protein binding
MFIPIGO:0042802identical protein binding
MFIBAGO:0042803protein homodimerization activity
MFIDAGO:0042803protein homodimerization activity
MFIPIGO:0042803protein homodimerization activity
MFIBAGO:0046982protein heterodimerization activity
MFIPIGO:0046982protein heterodimerization activity
MFIEAGO:0051087chaperone binding
MFIDAGO:0051434BH3 domain binding
MFIPIGO:0051434BH3 domain binding
CCIDAGO:0005635nuclear envelope
CCIBAGO:0005741mitochondrial outer membrane
CCTASGO:0005741mitochondrial outer membrane
CCIDAGO:0005757mitochondrial permeability transition pore complex
CCIDAGO:0005783endoplasmic reticulum
CCIDAGO:0005789endoplasmic reticulum membrane
CCIDAGO:0046930pore complex
CCHDAGO:0070062extracellular exosome
CCIDAGO:0071944cell periphery
CCIDAGO:0097136Bcl-2 family protein complex
CCIDAGO:0097144BAX complex
BPIEAGO:0001541ovarian follicle development
BPIEAGO:0001764neuron migration
BPIEAGO:0001777T cell homeostatic proliferation
BPIEAGO:0001782B cell homeostasis
BPIDAGO:0001783B cell apoptotic process
BPIEAGO:0001822kidney development
BPIBAGO:0001836release of cytochrome c from mitochondria
BPIDAGO:0001836release of cytochrome c from mitochondria
BPTASGO:0001844protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
BPIEAGO:0001974blood vessel remodeling
BPIEAGO:0002262myeloid cell homeostasis
BPIEAGO:0002352B cell negative selection
BPIEAGO:0002358B cell homeostatic proliferation
BPIEAGO:0002904positive regulation of B cell apoptotic process
BPTASGO:0006367transcription initiation from RNA polymerase II promoter
BPIEAGO:0006687glycosphingolipid metabolic process
BPIEAGO:0006808regulation of nitrogen utilization
BPIDAGO:0006915apoptotic process
BPIMPGO:0006915apoptotic process
BPNASGO:0006915apoptotic process
BPIDAGO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process
BPIMPGO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process
BPTASGO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
BPIEAGO:0007281germ cell development
BPIBAGO:0008053mitochondrial fusion
BPIDAGO:0008053mitochondrial fusion
BPICGO:0008625extrinsic apoptotic signaling pathway via death domain receptors
BPIBAGO:0008630intrinsic apoptotic signaling pathway in response to DNA damage
BPIDAGO:0008635activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
BPIDAGO:0008637apoptotic mitochondrial changes
BPIDAGO:0009636response to toxic substance
BPIEAGO:0009651response to salt stress
BPIDAGO:0010248establishment or maintenance of transmembrane electrochemical gradient
BPIEAGO:0010332response to gamma radiation
BPIEAGO:0016032viral process
BPIEAGO:0021854hypothalamus development
BPIEAGO:0021987cerebral cortex development
BPIDAGO:0032091negative regulation of protein binding
BPIDAGO:0032461positive regulation of protein oligomerization
BPTASGO:0032469endoplasmic reticulum calcium ion homeostasis
BPIEAGO:0032471negative regulation of endoplasmic reticulum calcium ion concentration
BPIDAGO:0032976release of matrix enzymes from mitochondria
BPIEAGO:0033137negative regulation of peptidyl-serine phosphorylation
BPIEAGO:0033599regulation of mammary gland epithelial cell proliferation
BPTASGO:0034620cellular response to unfolded protein
BPIEAGO:0034644cellular response to UV
BPIEAGO:0035234ectopic germ cell programmed cell death
BPIEAGO:0042475odontogenesis of dentin-containing tooth
BPTASGO:0042981regulation of apoptotic process
BPIBAGO:0043065positive regulation of apoptotic process
BPIDAGO:0043065positive regulation of apoptotic process
BPIMPGO:0043065positive regulation of apoptotic process
BPIDAGO:0043496regulation of protein homodimerization activity
BPIPIGO:0043497regulation of protein heterodimerization activity
BPIEAGO:0043524negative regulation of neuron apoptotic process
BPIDAGO:0043525positive regulation of neuron apoptotic process
BPIDAGO:0043653mitochondrial fragmentation involved in apoptotic process
BPIEAGO:0045136development of secondary sexual characteristics
BPIEAGO:0046666retinal cell programmed cell death
BPIEAGO:0048087positive regulation of developmental pigmentation
BPIEAGO:0048147negative regulation of fibroblast proliferation
BPIEAGO:0048515spermatid differentiation
BPIEAGO:0048597post-embryonic camera-type eye morphogenesis
BPIEAGO:0048678response to axon injury
BPIEAGO:0048873homeostasis of number of cells within a tissue
BPIDAGO:0051259protein complex oligomerization
BPIDAGO:0051260protein homooligomerization
BPIEAGO:0051281positive regulation of release of sequestered calcium ion into cytosol
BPIEAGO:0051402neuron apoptotic process
BPIDAGO:0051881regulation of mitochondrial membrane potential
BPIEAGO:0060011Sertoli cell proliferation
BPIEAGO:0060041retina development in camera-type eye
BPIEAGO:0060058positive regulation of apoptotic process involved in mammary gland involution
BPIEAGO:0060068vagina development
BPIMPGO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
BPTASGO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
BPIEAGO:0070242thymocyte apoptotic process
BPIEAGO:0070584mitochondrion morphogenesis
BPIEAGO:0072332intrinsic apoptotic signaling pathway by p53 class mediator
BPIDAGO:0090200positive regulation of release of cytochrome c from mitochondria
BPIMPGO:0090200positive regulation of release of cytochrome c from mitochondria
BPIDAGO:0097190apoptotic signaling pathway
BPIDAGO:0097191extrinsic apoptotic signaling pathway
BPIBAGO:0097192extrinsic apoptotic signaling pathway in absence of ligand
BPIDAGO:0097193intrinsic apoptotic signaling pathway
BPIEAGO:0097296activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
BPIMPGO:1900103positive regulation of endoplasmic reticulum unfolded protein response
BPTASGO:1901030positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
BPIEAGO:1902262apoptotic process involved in blood vessel morphogenesis
BPIEAGO:1902263apoptotic process involved in embryonic digit morphogenesis
BPIEAGO:1902445regulation of mitochondrial membrane permeability involved in programmed necrotic cell death
BPIMPGO:1902512positive regulation of apoptotic DNA fragmentation
BPTASGO:1903896positive regulation of IRE1-mediated unfolded protein response
BPIDAGO:1990117B cell receptor apoptotic signaling pathway
BPIEAGO:2001234negative regulation of apoptotic signaling pathway
BPIEAGO:2001241positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
BPIMPGO:2001244positive regulation of intrinsic apoptotic signaling pathway

Gene expression in normal tissue: BAX

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in BAX

DatabasePathway IDPathway Des.
biocartabadpathwayregulation of bad phosphorylation
biocartaceramidepathwayceramide signaling pathway
biocartachemicalpathwayapoptotic signaling in response to dna damage
biocartamitochondriapathwayrole of mitochondria in apoptotic signaling
biocartap53hypoxiapathwayhypoxia and p53 in the cardiovascular system
biocartaplk3pathwayregulation of cell cycle progression by plk3
reactomeR-HSA-109606Intrinsic Pathway for Apoptosis
reactomeR-HSA-111457Release of apoptotic factors from the mitochondria
reactomeR-HSA-114294Activation, translocation and oligomerization of BAX
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-5357801Programmed Cell Death
reactomeR-HSA-5633008TP53 Regulates Transcription of Cell Death Genes
reactomeR-HSA-6791312TP53 Regulates Transcription of Cell Cycle Genes
reactomeR-HSA-6803204TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
reactomeR-HSA-6804114TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8878166Transcriptional regulation by RUNX2
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9034015Signaling by NTRK3 (TRKC)
reactomeR-HSA-9603505NTRK3 as a dependence receptor
wikipathwaysWP1530miRNA Regulation of DNA Damage Response
wikipathwaysWP1742TP53 Network
wikipathwaysWP1772Apoptosis Modulation and Signaling
wikipathwaysWP1984Integrated Breast Cancer Pathway
wikipathwaysWP2034Leptin signaling pathway
wikipathwaysWP231TNF alpha Signaling Pathway
wikipathwaysWP2447Amyotrophic lateral sclerosis (ALS)
wikipathwaysWP2507Nanomaterial induced apoptosis
wikipathwaysWP2815Mammary gland development pathway - Involution (Stage 4 of 4)
wikipathwaysWP2873Aryl Hydrocarbon Receptor Pathway
wikipathwaysWP2882Nuclear Receptors Meta-Pathway
wikipathwaysWP3287Overview of nanoparticle effects
wikipathwaysWP3303Rac1-Pak1-p38-MMP-2 pathway
wikipathwaysWP3611Photodynamic therapy-induced AP-1 survival signaling.
wikipathwaysWP3614Photodynamic therapy-induced HIF-1 survival signaling
wikipathwaysWP3639Apoptotic Signaling Pathway
wikipathwaysWP3802TP53 Regulates Transcription of Cell Death Genes
wikipathwaysWP3872Regulation of Apoptosis by Parathyroid Hormone-related Protein
wikipathwaysWP3980Protein alkylation leading to liver fibrosis
wikipathwaysWP3982miRNA regulation of p53 pathway in prostate cancer
wikipathwaysWP4155Endometrial cancer
wikipathwaysWP4216Chromosomal and microsatellite instability in colorectal cancer
wikipathwaysWP707DNA Damage Response
wikipathwaysWP710DNA Damage Response (only ATM dependent)
pidcaspase_pathwayCaspase Cascade in Apoptosis
pidceramide_pathwayCeramide signaling pathway
pidhdac_classiii_pathwaySignaling events mediated by HDAC Class III
pidmyc_activpathwayValidated targets of C-MYC transcriptional activation
pidnfat_3pathwayRole of Calcineurin-dependent NFAT signaling in lymphocytes
pidp53downstreampathwayDirect p53 effectors
pidp73pathwayp73 transcription factor network
pidreg_gr_pathwayGlucocorticoid receptor regulatory network
pidsyndecan_2_pathwaySyndecan-2-mediated signaling events
pidtap63pathwayValidated transcriptional targets of TAp63 isoforms
pharmgkbPA150981002Vinka Alkaloid Pathway, Pharmacokinetics
kegghsa04071Sphingolipid signaling pathway - Homo sapiens (human)
kegghsa04115p53 signaling pathway - Homo sapiens (human)
kegghsa04141Protein processing in endoplasmic reticulum - Homo sapiens (human)
kegghsa04210Apoptosis - Homo sapiens (human)
kegghsa04211Longevity regulating pathway - Homo sapiens (human)
kegghsa04215Apoptosis - multiple species - Homo sapiens (human)
kegghsa04217Necroptosis - Homo sapiens (human)
kegghsa04722Neurotrophin signaling pathway - Homo sapiens (human)
kegghsa04932Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)
kegghsa04933AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
kegghsa05014Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human)
kegghsa05016Huntington,s disease - Homo sapiens (human)
kegghsa05020Prion diseases - Homo sapiens (human)
kegghsa05152Tuberculosis - Homo sapiens (human)
kegghsa05161Hepatitis B - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05202Transcriptional misregulation in cancer - Homo sapiens (human)
kegghsa05203Viral carcinogenesis - Homo sapiens (human)
kegghsa05210Colorectal cancer - Homo sapiens (human)
kegghsa05212Pancreatic cancer - Homo sapiens (human)
kegghsa05213Endometrial cancer - Homo sapiens (human)
kegghsa05214Glioma - Homo sapiens (human)
kegghsa05216Thyroid cancer - Homo sapiens (human)
kegghsa05217Basal cell carcinoma - Homo sapiens (human)
kegghsa05218Melanoma - Homo sapiens (human)
kegghsa05220Chronic myeloid leukemia - Homo sapiens (human)
kegghsa05222Small cell lung cancer - Homo sapiens (human)
kegghsa05223Non-small cell lung cancer - Homo sapiens (human)
kegghsa05224Breast cancer - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
kegghsa05226Gastric cancer - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD286Nsc 6328393
iGMDRD61Kinetin riboside3
iGMDRD512nutlin 34

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BAX