Summary: Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact, and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 3 is an immunologically distinct gene product from ankyrins 1 and 2, and was originally found at the axonal initial segment and nodes of Ranvier of neurons in the central and peripheral nervous systems. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011].

ankyrin 3MIM:600465Ensembl:ENSG00000151150HGNC:HGNC:494PA2480010q21.2

GO terms in ANK3

Term TypeEvidence TypeGO Term IDGO Des.
BPIMPGO:0000281mitotic cytokinesis
BPTASGO:0006888ER to Golgi vesicle-mediated transport
BPIMPGO:0007009plasma membrane organization
BPTASGO:0007016cytoskeletal anchoring at plasma membrane
BPIEAGO:0007165signal transduction
BPISSGO:0007528neuromuscular junction development
BPISSGO:0010628positive regulation of gene expression
BPISSGO:0010650positive regulation of cell communication by electrical coupling
BPISSGO:0010765positive regulation of sodium ion transport
BPISSGO:0010960magnesium ion homeostasis
BPISSGO:0019228neuronal action potential
BPISSGO:0034112positive regulation of homotypic cell-cell adhesion
BPIMPGO:0043001Golgi to plasma membrane protein transport
BPISSGO:0043266regulation of potassium ion transport
BPIMPGO:0045184establishment of protein localization
BPISSGO:0045838positive regulation of membrane potential
BPIBAGO:0050808synapse organization
BPISSGO:0071286cellular response to magnesium ion
BPIMPGO:0071709membrane assembly
BPISSGO:0071709membrane assembly
BPIBAGO:0072659protein localization to plasma membrane
BPIGIGO:0072659protein localization to plasma membrane
BPIMPGO:0072659protein localization to plasma membrane
BPISSGO:0072659protein localization to plasma membrane
BPIGIGO:0072660maintenance of protein location in plasma membrane
BPISSGO:0090314positive regulation of protein targeting to membrane
BPIBAGO:0099612protein localization to axon
BPISSGO:1900827positive regulation of membrane depolarization during cardiac muscle cell action potential
BPISSGO:1902260negative regulation of delayed rectifier potassium channel activity
BPISSGO:2000651positive regulation of sodium ion transmembrane transporter activity
BPISSGO:2001259positive regulation of cation channel activity
CCTASGO:0005783endoplasmic reticulum
CCIEAGO:0005794Golgi apparatus
CCIDAGO:0005886plasma membrane
CCISSGO:0005886plasma membrane
CCIDAGO:0005923bicellular tight junction
CCIDAGO:0009925basal plasma membrane
CCISSGO:0009986cell surface
CCIBAGO:0014704intercalated disc
CCISSGO:0014704intercalated disc
CCISSGO:0014731spectrin-associated cytoskeleton
CCIDAGO:0016323basolateral plasma membrane
CCIDAGO:0016328lateral plasma membrane
CCISSGO:0016529sarcoplasmic reticulum
CCISSGO:0030018Z disc
CCISSGO:0031594neuromuscular junction
CCIBAGO:0033268node of Ranvier
CCISSGO:0033268node of Ranvier
CCIBAGO:0033270paranode region of axon
CCISSGO:0043005neuron projection
CCIBAGO:0043194axon initial segment
CCIDAGO:0043194axon initial segment
CCISSGO:0043194axon initial segment
CCISSGO:0045211postsynaptic membrane
MFIMPGO:0005200structural constituent of cytoskeleton
MFIPIGO:0005515protein binding
MFISSGO:0008092cytoskeletal protein binding
MFISSGO:0030507spectrin binding
MFISSGO:0030674protein binding, bridging
MFIBAGO:0044325ion channel binding
MFISSGO:0044325ion channel binding
MFISSGO:0045296cadherin binding

Gene expression in normal tissue: ANK3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ANK3

DatabasePathway IDPathway Des.
wikipathwaysWP4148Splicing factor NOVA regulated synaptic proteins
kegghsa05205Proteoglycans in cancer - Homo sapiens (human)
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-199977ER to Golgi Anterograde Transport
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-373760L1CAM interactions
reactomeR-HSA-373760L1CAM interactions
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-445095Interaction between L1 and Ankyrins
reactomeR-HSA-445095Interaction between L1 and Ankyrins
reactomeR-HSA-446203Asparagine N-linked glycosylation
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-6807878COPI-mediated anterograde transport
reactomeR-HSA-948021Transport to the Golgi and subsequent modification

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD441TW 371
iGMDRD454JNK Inhibitor VIII1
iGMDRD322FK 8661

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ANK3