CASP1
Summary: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| caspase 1 | MIM:147678 | Ensembl:ENSG00000137752 | HGNC:HGNC:1499 | PA26083 | 11q22.3 |
GO terms in CASP1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004175 | endopeptidase activity |
| MF | IDA | GO:0004197 | cysteine-type endopeptidase activity |
| MF | TAS | GO:0004197 | cysteine-type endopeptidase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0008656 | cysteine-type endopeptidase activator activity involved in apoptotic process |
| MF | IPI | GO:0019900 | kinase binding |
| MF | IMP | GO:0042802 | identical protein binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IPI | GO:0050700 | CARD domain binding |
| MF | IBA | GO:0097153 | cysteine-type endopeptidase activity involved in apoptotic process |
| MF | IBA | GO:0097199 | cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
| MF | IBA | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis |
| CC | IEA | GO:0005576 | extracellular region |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005739 | mitochondrion |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0032991 | protein-containing complex |
| CC | IMP | GO:0032991 | protein-containing complex |
| CC | ISS | GO:0072557 | IPAF inflammasome complex |
| CC | IDA | GO:0072558 | NLRP1 inflammasome complex |
| CC | IDA | GO:0072559 | NLRP3 inflammasome complex |
| CC | IDA | GO:0097169 | AIM2 inflammasome complex |
| CC | IMP | GO:0097179 | protease inhibitor complex |
| BP | IEA | GO:0001666 | response to hypoxia |
| BP | IDA | GO:0006508 | proteolysis |
| BP | IBA | GO:0006915 | apoptotic process |
| BP | TAS | GO:0006915 | apoptotic process |
| BP | IBA | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | IEA | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IEA | GO:0010506 | regulation of autophagy |
| BP | IDA | GO:0016540 | protein autoprocessing |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IEA | GO:0032611 | interleukin-1 beta production |
| BP | IEA | GO:0033198 | response to ATP |
| BP | TAS | GO:0042981 | regulation of apoptotic process |
| BP | IEP | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IMP | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IMP | GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | IEA | GO:0050717 | positive regulation of interleukin-1 alpha secretion |
| BP | IDA | GO:0050718 | positive regulation of interleukin-1 beta secretion |
| BP | IMP | GO:0050718 | positive regulation of interleukin-1 beta secretion |
| BP | IEA | GO:0051882 | mitochondrial depolarization |
| BP | IEA | GO:0060081 | membrane hyperpolarization |
| BP | IEA | GO:0070269 | pyroptosis |
| BP | IMP | GO:0071222 | cellular response to lipopolysaccharide |
| BP | IEP | GO:0071260 | cellular response to mechanical stimulus |
| BP | IDA | GO:0071310 | cellular response to organic substance |
| BP | TAS | GO:0071345 | cellular response to cytokine stimulus |
| BP | IMP | GO:0071346 | cellular response to interferon-gamma |
| BP | IBA | GO:0097194 | execution phase of apoptosis |
| BP | IEA | GO:0097300 | programmed necrotic cell death |
| BP | IEA | GO:1901998 | toxin transport |
| BP | IMP | GO:1903265 | positive regulation of tumor necrosis factor-mediated signaling pathway |
Gene expression in normal tissue: CASP1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CASP1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| netpath | Pathway_AndrogenReceptor | AndrogenReceptor |
| pid | anthraxpathway | Cellular roles of Anthrax toxin |
| pid | ifngpathway | IFN-gamma pathway |
| pid | il1pathway | IL1-mediated signaling events |
| pid | p53downstreampathway | Direct p53 effectors |
| kegg | hsa04217 | Necroptosis - Homo sapiens (human) |
| kegg | hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04623 | Cytosolic DNA-sensing pathway - Homo sapiens (human) |
| kegg | hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa05014 | Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human) |
| kegg | hsa05132 | Salmonella infection - Homo sapiens (human) |
| kegg | hsa05133 | Pertussis - Homo sapiens (human) |
| kegg | hsa05134 | Legionellosis - Homo sapiens (human) |
| kegg | hsa05164 | Influenza A - Homo sapiens (human) |
| wikipathways | WP1433 | Nucleotide-binding Oligomerization Domain (NOD) pathway |
| wikipathways | WP1772 | Apoptosis Modulation and Signaling |
| wikipathways | WP2359 | Parkin-Ubiquitin Proteasomal System pathway |
| wikipathways | WP2447 | Amyotrophic lateral sclerosis (ALS) |
| wikipathways | WP254 | Apoptosis |
| wikipathways | WP3639 | Apoptotic Signaling Pathway |
| wikipathways | WP3802 | TP53 Regulates Transcription of Cell Death Genes |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168638 | NOD1/2 Signaling Pathway |
| reactome | R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
| reactome | R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-446652 | Interleukin-1 family signaling |
| reactome | R-HSA-448706 | Interleukin-1 processing |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes |
| reactome | R-HSA-622312 | Inflammasomes |
| reactome | R-HSA-622312 | Inflammasomes |
| reactome | R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-844456 | The NLRP3 inflammasome |
| reactome | R-HSA-844615 | The AIM2 inflammasome |
| reactome | R-HSA-844623 | The IPAF inflammasome |
| reactome | R-HSA-9008059 | Interleukin-37 signaling |
| biocarta | caspasepathway | caspase cascade in apoptosis |
| biocarta | d4gdipathway | d4gdi signaling pathway |
| biocarta | irespathway | internal ribosome entry pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD280 | CYTOCHALASIN B | 4 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD314 | Tanespimycin | 1 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 6 |
| iGMDRD427 | ABT737 | 4 |
| iGMDRD483 | SCH-529074 | 3 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD347 | Y-39983 | 1 |
| iGMDRD387 | CHIR-99021 | 3 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD245 | FH535 | 1 |
| iGMDRD264 | Bryostatin 1 | 1 |
| iGMDRD577 | BIX01294 | 9 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD440 | Nutlin-3A | 1 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CASP1
CLASSFICATION
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