iGMDRD364

Canonical SMILES: CC1=NC=C(C=C1)OC2=C(C=C(C=C2)NC3=NC=NC4=C3C=C(C=C4)C=CCNC(=O)COC)C

InChI: InChI=1S/C27H27N5O3/c1-18-13-21(8-11-25(18)35-22-9-6-19(2)29-15-22)32-27-23-14-20(7-10-24(23)30-17-31-27)5-4-12-28-26(33)16-34-3/h4-11,13-15,17H,12,16H2,1-3H3,(H,28,33)(H,30,31,32)/b5-4+

InChI Key: LLVZBTWPGQVVLW-SNAWJCMRSA-N

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Standard Name
CHEMBL
Pubchem CID
DRUGBANK ID
Drug Status
Drug Type
Standard NameCP-724714
CHEMBLCHEMBL483321
Pubchem CID9874910
DRUGBANK IDDB12302
Drug StatusAlone
Drug TypeSmall Molecule


Drug Targets:

ERBB2

Drug Pathways:

EGFR signaling

Drug-model tissue-cancer distribution: Bubble Plot

BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: Breast Carcinoma model num: 3undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 2LYMPtissue: LYMP cancer: LYMPH model num: 0LYMPHtissue: LYMPH cancer: Diffuse Large B-Cell Lymphoma (DLBCL) model num: 1STOMACtissue: STOMAC cancer: STOMACH model num: 0STOMACHtissue: STOMACH cancer: Esophageal Adenocarcinoma (ESCA) model num: 1BONtissue: BON cancer: BONE model num: 0BONEtissue: BONE cancer: Acute Myeloid Leukemia (AML) model num: 1LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: Lung Adenocarcinoma (LUAD) model num: 1OTHEtissue: OTHE cancer: OTHER model num: 0OTHERtissue: OTHER cancer: Cancer of Unknown Primary (CUP) model num: 1

Drug-gene pathway enrichments

9reactome: Signal Transduction5reactome: Generic Transcription Pathway5reactome: Gene expression (Transcription)5reactome: RNA Polymerase II Transcription4reactome: Developmental Biology4reactome: Signaling by ERBB24reactome: SHC1 events in ERBB2 signaling4reactome: Disease4reactome: Diseases of signal transduction4reactome: Signaling by Receptor Tyrosine Kinases

Drug-gene GO enrichments

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
6597 SMARCA4 1
2033 EP300 1
2064 ERBB2 1
171023 ASXL1 1
Showing 1 to 4 of 6 rows

Gene in drug-gene network: Network Plot

Models in CP-724714

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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