PLCB1

Summary: The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namephospholipase C beta 1
OMIM IDMIM:607120
Ensembl IDEnsembl:ENSG00000182621
HGNC IDHGNC:HGNC:15917
PHARMGKB IDPA33384
Map Location20p12.3

GO terms in PLCB1


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
MF ISS GO:0004435 phosphatidylinositol phospholipase C activity
MF NAS GO:0004435 phosphatidylinositol phospholipase C activity
MF TAS GO:0004435 phosphatidylinositol phospholipase C activity
MF TAS GO:0004629 phospholipase C activity
MF IDA GO:0005096 GTPase activator activity
MF IEA GO:0005509 calcium ion binding
Showing 1 to 6 of 52 rows rows per page

Gene expression in normal tissue: PLCB1

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

SKItissue: SKI cancer: SKIN model num: 0SKINtissue: SKIN cancer: Cutaneous Melanoma (SKCM) model num: 2

Gene-drug pathway distribution

Protein stability and degradation1DNA replication1

Pathways in PLCB1


Loading, please wait...
Database
Pathway ID
Pathway Des.
humancyc LIPASYN-PWY phospholipases
humancyc PWY-6351 D-myo-inositol (1,4,5)-trisphosphate biosynthesis
humancyc PWY-6367 D-myo-inositol-5-phosphate metabolism
humancyc PWY-6371 superpathway of inositol phosphate compounds
kegg hsa00562 Inositol phosphate metabolism - Homo sapiens (human)
kegg hsa04015 Rap1 signaling pathway - Homo sapiens (human)
Showing 1 to 6 of 174 rows rows per page

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD293 Bleomycin 1
iGMDRD135 Lenalidomide 1
Showing 1 to 2 of 2 rows

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PLCB1

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​

SITE
DATATYPES
CLASSFICATION
Map

Copyright © 2018 Modellab | All Rights Reserved

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.