NPM1
Summary: The protein encoded by this gene is involved in several cellular processes, including centrosome duplication, protein chaperoning, and cell proliferation. The encoded phosphoprotein shuttles between the nucleolus, nucleus, and cytoplasm, chaperoning ribosomal proteins and core histones from the nucleus to the cytoplasm. This protein is also known to sequester the tumor suppressor ARF in the nucleolus, protecting it from degradation until it is needed. Mutations in this gene are associated with acute myeloid leukemia. Dozens of pseudogenes of this gene have been identified. [provided by RefSeq, Aug 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| nucleophosmin 1 | MIM:164040 | Ensembl:ENSG00000181163 | HGNC:HGNC:7910 | PA31712 | 5q35.1 |
GO terms in NPM1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0001047 | core promoter binding |
| MF | IBA | GO:0003682 | chromatin binding |
| MF | IDA | GO:0003713 | transcription coactivator activity |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IBA | GO:0003723 | RNA binding |
| MF | IDA | GO:0003723 | RNA binding |
| MF | IDA | GO:0004860 | protein kinase inhibitor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0008134 | transcription factor binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IDA | GO:0030957 | Tat protein binding |
| MF | IPI | GO:0033613 | activating transcription factor binding |
| MF | IBA | GO:0042393 | histone binding |
| MF | IDA | GO:0042393 | histone binding |
| MF | IDA | GO:0042803 | protein homodimerization activity |
| MF | IDA | GO:0043023 | ribosomal large subunit binding |
| MF | IDA | GO:0043024 | ribosomal small subunit binding |
| MF | IMP | GO:0046982 | protein heterodimerization activity |
| MF | IDA | GO:0051059 | NF-kappaB binding |
| MF | ISS | GO:0051059 | NF-kappaB binding |
| MF | IDA | GO:0051082 | unfolded protein binding |
| MF | ISS | GO:0051082 | unfolded protein binding |
| BP | IBA | GO:0000055 | ribosomal large subunit export from nucleus |
| BP | IBA | GO:0000056 | ribosomal small subunit export from nucleus |
| BP | IDA | GO:0006281 | DNA repair |
| BP | IDA | GO:0006334 | nucleosome assembly |
| BP | IBA | GO:0006338 | chromatin remodeling |
| BP | TAS | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IBA | GO:0006407 | rRNA export from nucleus |
| BP | TAS | GO:0006886 | intracellular protein transport |
| BP | IDA | GO:0006913 | nucleocytoplasmic transport |
| BP | TAS | GO:0006913 | nucleocytoplasmic transport |
| BP | IMP | GO:0007098 | centrosome cycle |
| BP | ISS | GO:0007098 | centrosome cycle |
| BP | NAS | GO:0007165 | signal transduction |
| BP | IMP | GO:0007569 | cell aging |
| BP | ISS | GO:0007569 | cell aging |
| BP | IDA | GO:0008104 | protein localization |
| BP | IDA | GO:0008284 | positive regulation of cell proliferation |
| BP | IMP | GO:0008285 | negative regulation of cell proliferation |
| BP | ISS | GO:0008285 | negative regulation of cell proliferation |
| BP | IBA | GO:0010824 | regulation of centrosome duplication |
| BP | IMP | GO:0010826 | negative regulation of centrosome duplication |
| BP | IEA | GO:0016032 | viral process |
| BP | IDA | GO:0032071 | regulation of endodeoxyribonuclease activity |
| BP | TAS | GO:0034080 | CENP-A containing nucleosome assembly |
| BP | IDA | GO:0034644 | cellular response to UV |
| BP | TAS | GO:0042255 | ribosome assembly |
| BP | IBA | GO:0042273 | ribosomal large subunit biogenesis |
| BP | IBA | GO:0042274 | ribosomal small subunit biogenesis |
| BP | IDA | GO:0043066 | negative regulation of apoptotic process |
| BP | NAS | GO:0043066 | negative regulation of apoptotic process |
| BP | IDA | GO:0044387 | negative regulation of protein kinase activity by regulation of protein phosphorylation |
| BP | IDA | GO:0045727 | positive regulation of translation |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IBA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0046599 | regulation of centriole replication |
| BP | IMP | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | IDA | GO:0051259 | protein complex oligomerization |
| BP | IDA | GO:0060699 | regulation of endoribonuclease activity |
| BP | IDA | GO:0060735 | regulation of eIF2 alpha phosphorylation by dsRNA |
| BP | IMP | GO:1902629 | regulation of mRNA stability involved in cellular response to UV |
| BP | IDA | GO:1902751 | positive regulation of cell cycle G2/M phase transition |
| CC | HDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | ISS | GO:0005634 | nucleus |
| CC | IBA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005730 | nucleolus |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | IBA | GO:0005813 | centrosome |
| CC | IDA | GO:0005813 | centrosome |
| CC | ISS | GO:0005813 | centrosome |
| CC | TAS | GO:0005829 | cytosol |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | HDA | GO:0016020 | membrane |
| CC | IDA | GO:0031616 | spindle pole centrosome |
| CC | IDA | GO:0032991 | protein-containing complex |
| CC | IDA | GO:0032993 | protein-DNA complex |
| CC | IDA | GO:1990904 | ribonucleoprotein complex |
Gene expression in normal tissue: NPM1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NPM1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | aurora_b_pathway | Aurora B signaling |
| pid | bard1pathway | BARD1 signaling events |
| pid | hif1_tfpathway | HIF-1-alpha transcription factor network |
| pid | myc_activpathway | Validated targets of C-MYC transcriptional activation |
| reactome | R-HSA-162906 | HIV Infection |
| reactome | R-HSA-162906 | HIV Infection |
| reactome | R-HSA-162909 | Host Interactions of HIV factors |
| reactome | R-HSA-162909 | Host Interactions of HIV factors |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-177243 | Interactions of Rev with host cellular proteins |
| reactome | R-HSA-177243 | Interactions of Rev with host cellular proteins |
| reactome | R-HSA-180746 | Nuclear import of Rev protein |
| reactome | R-HSA-180746 | Nuclear import of Rev protein |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-3899300 | SUMOylation of transcription cofactors |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere |
| reactome | R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes |
| reactome | R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73886 | Chromosome Maintenance |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-774815 | Nucleosome assembly |
| reactome | R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors |
| reactome | R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD88 | AICA ribonucleotide | 1 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD221 | Tamoxifen | 2 |
| iGMDRD434 | BMS-536924 | 4 |
| iGMDRD278 | TTNPB | 2 |
| iGMDRD202 | Curcumin | 2 |
| iGMDRD300 | Tozasertib | 1 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD286 | Nsc 632839 | 1 |
| iGMDRD405 | PIK-75 | 2 |
| iGMDRD701 | NVP-AUY922 | 2 |
| iGMDRD948 | MLL1 inhibitor | 2 |
| iGMDRD162 | All-trans Retinoic Acid | 3 |
| iGMDRD813 | Anti-CD123 | 1 |
| iGMDRD512 | nutlin 3 | 1 |
| iGMDRD607 | Ubistatin B | 2 |
| iGMDRD584 | VER 155008 | 2 |
| iGMDRD475 | BX 912 | 1 |
| iGMDRD65 | Daunorubicin | 3 |
| iGMDRD187 | BRD9876 | 2 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD802 | 4-methylfasudil | 2 |
| iGMDRD513 | BML-259 | 2 |
| iGMDRD149 | NSC348884 | 2 |
| iGMDRD814 | Anti-CD33 | 1 |
| iGMDRD474 | Avrainvillamide | 2 |
| iGMDRD598 | QS-11 | 2 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD928 | Induction Therapy | 1 |
| iGMDRD369 | TGX-115 | 2 |
| iGMDRD893 | DOT1L inhibitor | 2 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD19 | VALPROIC ACID | 1 |
| iGMDRD164 | all trans Retinoic Acid (non-FLT3 ITD AML) | 1 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD135 | Lenalidomide | 1 |
| iGMDRD781 | Sirolimus | 6 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD126 | Tipifarnib | 4 |
| iGMDRD361 | 5Z-7-Oxozeaenol | 1 |
| iGMDRD210 | AC55649 | 1 |
| iGMDRD375 | GW-405833 | 2 |
| iGMDRD470 | Trametinib | 1 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 2 |
| iGMDRD61 | Kinetin riboside | 4 |
| iGMDRD163 | all trans Retinoic Acid | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NPM1
CLASSFICATION
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