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NPM1

Summary: The protein encoded by this gene is involved in several cellular processes, including centrosome duplication, protein chaperoning, and cell proliferation. The encoded phosphoprotein shuttles between the nucleolus, nucleus, and cytoplasm, chaperoning ribosomal proteins and core histones from the nucleus to the cytoplasm. This protein is also known to sequester the tumor suppressor ARF in the nucleolus, protecting it from degradation until it is needed. Mutations in this gene are associated with acute myeloid leukemia. Dozens of pseudogenes of this gene have been identified. [provided by RefSeq, Aug 2017].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Namenucleophosmin 1 OMIM IDMIM:164040 Ensembl IDEnsembl:ENSG00000181163 HGNC IDHGNC:HGNC:7910 PHARMGKB IDPA31712 Map Location5q35.1

Gene Categories:

DRUGGABLE GENOME TYROSINE KINASE KINASE DNA REPAIR TUMOR SUPPRESSOR TRANSCRIPTION FACTOR BINDING CLINICALLY ACTIONABLE

GO terms in NPM1

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Term Type	Evidence Type	GO Term ID	GO Des.
MF	IDA	GO:0001047	core promoter binding
MF	IBA	GO:0003682	chromatin binding
MF	IDA	GO:0003713	transcription coactivator activity
MF	HDA	GO:0003723	RNA binding
MF	IBA	GO:0003723	RNA binding
MF	IDA	GO:0003723	RNA binding

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Gene expression in normal tissue: NPM1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NPM1

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Database	Pathway ID	Pathway Des.
pid	aurora_b_pathway	Aurora B signaling
pid	bard1pathway	BARD1 signaling events
pid	hif1_tfpathway	HIF-1-alpha transcription factor network
pid	myc_activpathway	Validated targets of C-MYC transcriptional activation
reactome	R-HSA-162906	HIV Infection
reactome	R-HSA-162906	HIV Infection

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD88	AICA ribonucleotide	1
iGMDRD6	AM-580	2
iGMDRD221	Tamoxifen	2
iGMDRD434	BMS-536924	4

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NPM1

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.