NPM1
Summary: The protein encoded by this gene is involved in several cellular processes, including centrosome duplication, protein chaperoning, and cell proliferation. The encoded phosphoprotein shuttles between the nucleolus, nucleus, and cytoplasm, chaperoning ribosomal proteins and core histones from the nucleus to the cytoplasm. This protein is also known to sequester the tumor suppressor ARF in the nucleolus, protecting it from degradation until it is needed. Mutations in this gene are associated with acute myeloid leukemia. Dozens of pseudogenes of this gene have been identified. [provided by RefSeq, Aug 2017].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Namenucleophosmin 1 OMIM IDMIM:164040 Ensembl IDEnsembl:ENSG00000181163 HGNC IDHGNC:HGNC:7910 PHARMGKB IDPA31712 Map Location5q35.1 | |||||
GO terms in NPM1
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0001047 | core promoter binding |
| MF | IBA | GO:0003682 | chromatin binding |
| MF | IDA | GO:0003713 | transcription coactivator activity |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IBA | GO:0003723 | RNA binding |
| MF | IDA | GO:0003723 | RNA binding |
Gene expression in normal tissue: NPM1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NPM1
Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | aurora_b_pathway | Aurora B signaling |
| pid | bard1pathway | BARD1 signaling events |
| pid | hif1_tfpathway | HIF-1-alpha transcription factor network |
| pid | myc_activpathway | Validated targets of C-MYC transcriptional activation |
| reactome | R-HSA-162906 | HIV Infection |
| reactome | R-HSA-162906 | HIV Infection |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NPM1
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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