EEF2
Summary: This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| eukaryotic translation elongation factor 2 | MIM:130610 | Ensembl:ENSG00000167658 | HGNC:HGNC:3214 | PA27650 | 19p13.3 |
GO terms in EEF2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0002039 | p53 binding |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IEA | GO:0003746 | translation elongation factor activity |
| MF | IEA | GO:0003924 | GTPase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005525 | GTP binding |
| MF | IEA | GO:0008097 | 5S rRNA binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IEA | GO:0043022 | ribosome binding |
| MF | HDA | GO:0045296 | cadherin binding |
| MF | IEA | GO:0051015 | actin filament binding |
| CC | TAS | GO:0005576 | extracellular region |
| CC | HDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | HDA | GO:0016020 | membrane |
| CC | IDA | GO:0016235 | aggresome |
| CC | TAS | GO:0034774 | secretory granule lumen |
| CC | IEA | GO:0042788 | polysomal ribosome |
| CC | IEA | GO:0045121 | membrane raft |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | TAS | GO:1904813 | ficolin-1-rich granule lumen |
| CC | IDA | GO:1990904 | ribonucleoprotein complex |
| BP | IEA | GO:0002244 | hematopoietic progenitor cell differentiation |
| BP | IEA | GO:0002931 | response to ischemia |
| BP | IEA | GO:0003009 | skeletal muscle contraction |
| BP | IBA | GO:0006414 | translational elongation |
| BP | TAS | GO:0006414 | translational elongation |
| BP | IEA | GO:0007568 | aging |
| BP | IEA | GO:0014009 | glial cell proliferation |
| BP | IEA | GO:0032355 | response to estradiol |
| BP | IEA | GO:0034976 | response to endoplasmic reticulum stress |
| BP | IEA | GO:0035914 | skeletal muscle cell differentiation |
| BP | IEA | GO:0042542 | response to hydrogen peroxide |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | IEA | GO:0045471 | response to ethanol |
| BP | IMP | GO:0045727 | positive regulation of translation |
| BP | IEA | GO:0051593 | response to folic acid |
| BP | IEA | GO:1990416 | cellular response to brain-derived neurotrophic factor stimulus |
| BP | IEA | GO:2000767 | positive regulation of cytoplasmic translation |
Gene expression in normal tissue: EEF2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EEF2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-156842 | Eukaryotic Translation Elongation |
| reactome | R-HSA-156842 | Eukaryotic Translation Elongation |
| reactome | R-HSA-156902 | Peptide chain elongation |
| reactome | R-HSA-156902 | Peptide chain elongation |
| reactome | R-HSA-163841 | Gamma carboxylation, hypusine formation and arylsulfatase activation |
| reactome | R-HSA-163841 | Gamma carboxylation, hypusine formation and arylsulfatase activation |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5336415 | Uptake and function of diphtheria toxin |
| reactome | R-HSA-5339562 | Uptake and actions of bacterial toxins |
| reactome | R-HSA-5358493 | Synthesis of diphthamide-EEF2 |
| reactome | R-HSA-5358493 | Synthesis of diphthamide-EEF2 |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| reactome | R-HSA-72766 | Translation |
| reactome | R-HSA-72766 | Translation |
| reactome | R-HSA-8876725 | Protein methylation |
| pid | mtor_4pathway | mTOR signaling pathway |
| kegg | hsa04152 | AMPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| wikipathways | WP107 | Translation Factors |
| wikipathways | WP1403 | AMP-activated Protein Kinase (AMPK) Signaling |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD284 | Palbociclib | 1 |
| iGMDRD117 | Docetaxel | 1 |
| iGMDRD481 | Dactolisib | 1 |
| iGMDRD459 | RO-3306 | 1 |
| iGMDRD551 | Ponatinib | 1 |
| iGMDRD206 | SJ-172550 | 1 |
| iGMDRD467 | Motesanib | 1 |
| iGMDRD493 | GSK269962A | 1 |
| iGMDRD96 | S-Trityl-L-cysteine | 1 |
| iGMDRD291 | AC1NS4S0 | 1 |
| iGMDRD431 | NU-7441 | 1 |
| iGMDRD131 | Erlotinib | 1 |
| iGMDRD421 | AZD7762 | 1 |
| iGMDRD87 | Epigallocatechin-3-monogallate | 1 |
| iGMDRD119 | Temsirolimus | 1 |
| iGMDRD185 | DMOG | 1 |
| iGMDRD63 | Camptothecin | 1 |
| iGMDRD125 | BIRB-796 | 1 |
| iGMDRD587 | CHEMBL585951 | 1 |
| iGMDRD79 | Gemcitabine | 1 |
| iGMDRD382 | CEP-701 | 1 |
| iGMDRD262 | KU-55933 | 1 |
| iGMDRD401 | Afatinib | 1 |
| iGMDRD281 | Vinorelbine base | 1 |
| iGMDRD253 | Vincaleukoblastine | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EEF2
CLASSFICATION
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