EEF2


Summary: This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
eukaryotic translation elongation factor 2MIM:130610Ensembl:ENSG00000167658HGNC:HGNC:3214PA2765019p13.3

GO terms in EEF2


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0002039p53 binding
MFHDAGO:0003723RNA binding
MFIEAGO:0003746translation elongation factor activity
MFIEAGO:0003924GTPase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005525GTP binding
MFIEAGO:00080975S rRNA binding
MFIPIGO:0019901protein kinase binding
MFIEAGO:0043022ribosome binding
MFHDAGO:0045296cadherin binding
MFIEAGO:0051015actin filament binding
CCTASGO:0005576extracellular region
CCHDAGO:0005634nucleus
CCIDAGO:0005737cytoplasm
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIDAGO:0005886plasma membrane
CCHDAGO:0016020membrane
CCIDAGO:0016235aggresome
CCTASGO:0034774secretory granule lumen
CCIEAGO:0042788polysomal ribosome
CCIEAGO:0045121membrane raft
CCHDAGO:0070062extracellular exosome
CCTASGO:1904813ficolin-1-rich granule lumen
CCIDAGO:1990904ribonucleoprotein complex
BPIEAGO:0002244hematopoietic progenitor cell differentiation
BPIEAGO:0002931response to ischemia
BPIEAGO:0003009skeletal muscle contraction
BPIBAGO:0006414translational elongation
BPTASGO:0006414translational elongation
BPIEAGO:0007568aging
BPIEAGO:0014009glial cell proliferation
BPIEAGO:0032355response to estradiol
BPIEAGO:0034976response to endoplasmic reticulum stress
BPIEAGO:0035914skeletal muscle cell differentiation
BPIEAGO:0042542response to hydrogen peroxide
BPTASGO:0043312neutrophil degranulation
BPIEAGO:0045471response to ethanol
BPIMPGO:0045727positive regulation of translation
BPIEAGO:0051593response to folic acid
BPIEAGO:1990416cellular response to brain-derived neurotrophic factor stimulus
BPIEAGO:2000767positive regulation of cytoplasmic translation

Gene expression in normal tissue: EEF2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in EEF2


DatabasePathway IDPathway Des.
reactomeR-HSA-156842Eukaryotic Translation Elongation
reactomeR-HSA-156842Eukaryotic Translation Elongation
reactomeR-HSA-156902Peptide chain elongation
reactomeR-HSA-156902Peptide chain elongation
reactomeR-HSA-163841Gamma carboxylation, hypusine formation and arylsulfatase activation
reactomeR-HSA-163841Gamma carboxylation, hypusine formation and arylsulfatase activation
reactomeR-HSA-1643685Disease
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-5336415Uptake and function of diphtheria toxin
reactomeR-HSA-5339562Uptake and actions of bacterial toxins
reactomeR-HSA-5358493Synthesis of diphthamide-EEF2
reactomeR-HSA-5358493Synthesis of diphthamide-EEF2
reactomeR-HSA-5663205Infectious disease
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-6798695Neutrophil degranulation
reactomeR-HSA-72766Translation
reactomeR-HSA-72766Translation
reactomeR-HSA-8876725Protein methylation
pidmtor_4pathwaymTOR signaling pathway
kegghsa04152AMPK signaling pathway - Homo sapiens (human)
kegghsa04921Oxytocin signaling pathway - Homo sapiens (human)
wikipathwaysWP107Translation Factors
wikipathwaysWP1403AMP-activated Protein Kinase (AMPK) Signaling
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD284Palbociclib1
iGMDRD117Docetaxel1
iGMDRD481Dactolisib1
iGMDRD459RO-33061
iGMDRD551Ponatinib1
iGMDRD206SJ-1725501
iGMDRD467Motesanib1
iGMDRD493GSK269962A1
iGMDRD96S-Trityl-L-cysteine1
iGMDRD291AC1NS4S01
iGMDRD431NU-74411
iGMDRD131Erlotinib1
iGMDRD421AZD77621
iGMDRD87Epigallocatechin-3-monogallate1
iGMDRD119Temsirolimus1
iGMDRD185DMOG1
iGMDRD63Camptothecin1
iGMDRD125BIRB-7961
iGMDRD587CHEMBL5859511
iGMDRD79Gemcitabine1
iGMDRD382CEP-7011
iGMDRD262KU-559331
iGMDRD401Afatinib1
iGMDRD281Vinorelbine base1
iGMDRD253Vincaleukoblastine1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in EEF2

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