ARID4B
Summary: This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:609696 Ensembl IDEnsembl:ENSG00000054267 HGNC IDHGNC:HGNC:15550 PHARMGKB IDPA134940494 Map Location1q42.3 | |||||
Gene Categories:
HISTONE MODIFICATIONGO terms in ARID4B
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ND | GO:0003674 | molecular_function |
| MF | TAS | GO:0004407 | histone deacetylase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0044212 | transcription regulatory region DNA binding |
| BP | IEA | GO:0006349 | regulation of gene expression by genetic imprinting |
Gene expression in normal tissue: ARID4B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ARID4B
Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2003 | miR-targeted genes in leukocytes - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP3651 | Pathways Affected in Adenoid Cystic Carcinoma |
| reactome | R-HSA-212165 | Epigenetic regulation of gene expression |
| reactome | R-HSA-3214815 | HDACs deacetylate histones |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD284 | Palbociclib | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ARID4B
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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