SP110
Summary: The nuclear body is a multiprotein complex that may have a role in the regulation of gene transcription. This gene is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. In addition, it has been suggested that the protein may play a role in ribosome biogenesis and in the induction of myeloid cell differentiation. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| SP110 nuclear body protein | MIM:604457 | Ensembl:ENSG00000135899 | HGNC:HGNC:5401 | PA35104 | 2q37.1 |
GO terms in SP110
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0016032 | viral process |
| CC | IDA | GO:0005634 | nucleus |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IEA | GO:0003677 | DNA binding |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: SP110
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SP110
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD61 | Kinetin riboside | 4 |
| iGMDRD679 | Bistramide A | 1 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD188 | Piperlongumine | 5 |
| iGMDRD100 | Zebularine | 4 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD562 | Navitoclax | 4 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD451 | Serdemetan | 4 |
| iGMDRD513 | BML-259 | 1 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD284 | Palbociclib | 1 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD318 | PAC-1 | 4 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD85 | Ursolic acid | 1 |
| iGMDRD351 | GW843682X | 6 |
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD872 | BRD7137 | 4 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD300 | Tozasertib | 8 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD158 | NSC141540 | 6 |
| iGMDRD271 | Brefeldin A | 1 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD434 | BMS-536924 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SP110
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