iGMDRD610

Canonical SMILES: COC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=NN3C4CCN(CC4)C(=O)OC)C(=N2)N5CCOCC5

InChI: InChI=1S/C24H29N7O5/c1-34-23(32)26-17-5-3-16(4-6-17)20-27-21(29-11-13-36-14-12-29)19-15-25-31(22(19)28-20)18-7-9-30(10-8-18)24(33)35-2/h3-6,15,18H,7-14H2,1-2H3,(H,26,32)

InChI Key: IMXHGCRIEAKIBU-UHFFFAOYSA-N

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Standard Name
Pubchem CID
Drug Status
Drug Type
Standard NameWYE-354
Pubchem CID44219700
Drug StatusAlone
Drug TypeSmall Molecule

Drug-model tissue-cancer distribution: Bubble Plot

BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: Colorectal Cancer model num: 1

Drug-gene pathway enrichments

1kegg: mTOR signaling pathway - Homo sapiens (human)1kegg: HIF-1 signaling pathway - Homo sapiens (human)1kegg: PI3K-Akt signaling pathway - Homo sapiens (human)1kegg: AMPK signaling pathway - Homo sapiens (human)1kegg: Cellular senescence - Homo sapiens (human)1kegg: Longevity regulating pathway - Homo sapiens (human)1kegg: ErbB signaling pathway - Homo sapiens (human)1kegg: RNA transport - Homo sapiens (human)1pid: Insulin Pathway1netpath: Leptin

Drug-gene GO enrichments

2MF: eukaryotic initiation factor 4E binding2BP: negative regulation of translational initiation2CC: cytosol1BP: cellular response to dexamethasone stimulus1MF: translation repressor activity1MF: protein binding1BP: TOR signaling1BP: G1/S transition of mitotic cell cycle1BP: IRES-dependent translational initiation of linear mRNA1BP: insulin receptor signaling pathway

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
1978 EIF4EBP1 1
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Gene in drug-gene network: Network Plot

Models in WYE-354

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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