ULK2


Summary: This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Dec 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
unc-51 like autophagy activating kinase 2MIM:608650Ensembl:ENSG00000083290HGNC:HGNC:13480PA3778017p11.2

GO terms in ULK2


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0004674protein serine/threonine kinase activity
MFIDAGO:0004674protein serine/threonine kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
CCIBAGO:0000407phagophore assembly site
CCIBAGO:0005829cytosol
CCIBAGO:0016020membrane
CCIEAGO:0030659cytoplasmic vesicle membrane
CCIDAGO:0034045phagophore assembly site membrane
BPIBAGO:0000045autophagosome assembly
BPIDAGO:0006914autophagy
BPIEAGO:0007165signal transduction
BPIBAGO:0010506regulation of autophagy
BPISSGO:0042594response to starvation
BPIBAGO:0046777protein autophosphorylation
BPIDAGO:0046777protein autophosphorylation
BPIEAGO:0048671negative regulation of collateral sprouting
BPIBAGO:0048675axon extension
BPIGIGO:0075044autophagy of host cells involved in interaction with symbiont

Gene expression in normal tissue: ULK2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ULK2


DatabasePathway IDPathway Des.
kegghsa04136Autophagy - other - Homo sapiens (human)
kegghsa04140Autophagy - animal - Homo sapiens (human)
kegghsa04150mTOR signaling pathway - Homo sapiens (human)
pidmtor_4pathwaymTOR signaling pathway
wikipathwaysWP1471Target Of Rapamycin (TOR) Signaling
wikipathwaysWP2509Nanoparticle triggered autophagic cell death

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD772BRD47703
iGMDRD425ERASTIN1
iGMDRD151CHM-13
iGMDRD126Tipifarnib2
iGMDRD781Sirolimus2
iGMDRD494Neopeltolide1
iGMDRD427ABT7372
iGMDRD193Fqi13
iGMDRD152179324-69-71
iGMDRD61Kinetin riboside2
iGMDRD201SKI II3
iGMDRD446LY 21832401
iGMDRD466Chaetocin1
iGMDRD679Bistramide A1
iGMDRD260FQI-23
iGMDRD138PX 123
iGMDRD270Ciclosporin1
iGMDRD52Rotenone3
iGMDRD187BRD98763
iGMDRD171Pemetrexed1
iGMDRD562Navitoclax2
iGMDRD888Compound 443
iGMDRD887Compound 23 citrate1
iGMDRD100Zebularine1
iGMDRD188Piperlongumine2
iGMDRD451Serdemetan3
iGMDRD268Cerulenin1
iGMDRD64Parbendazole1
iGMDRD512nutlin 34
iGMDRD307Manumycin A6
iGMDRD48Dexamethasone3
iGMDRD532Olaparib3
iGMDRD351GW843682X3
iGMDRD85Ursolic acid4
iGMDRD901ELCPK3
iGMDRD5Tyrphostin AG 14784
iGMDRD121GMX17782
iGMDRD137Indisulam2
iGMDRD271Brefeldin A3
iGMDRD213SMR0000686503
iGMDRD705Nakiterpiosin3
iGMDRD289Parthenolide3
iGMDRD662JQ-13
iGMDRD286Nsc 6328392
iGMDRD871BRD63682
iGMDRD42Vorinostat1
iGMDRD147Prima-13

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ULK2

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