ULK2
Summary: This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Dec 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| unc-51 like autophagy activating kinase 2 | MIM:608650 | Ensembl:ENSG00000083290 | HGNC:HGNC:13480 | PA37780 | 17p11.2 |
GO terms in ULK2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| CC | IBA | GO:0000407 | phagophore assembly site |
| CC | IBA | GO:0005829 | cytosol |
| CC | IBA | GO:0016020 | membrane |
| CC | IEA | GO:0030659 | cytoplasmic vesicle membrane |
| CC | IDA | GO:0034045 | phagophore assembly site membrane |
| BP | IBA | GO:0000045 | autophagosome assembly |
| BP | IDA | GO:0006914 | autophagy |
| BP | IEA | GO:0007165 | signal transduction |
| BP | IBA | GO:0010506 | regulation of autophagy |
| BP | ISS | GO:0042594 | response to starvation |
| BP | IBA | GO:0046777 | protein autophosphorylation |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | IEA | GO:0048671 | negative regulation of collateral sprouting |
| BP | IBA | GO:0048675 | axon extension |
| BP | IGI | GO:0075044 | autophagy of host cells involved in interaction with symbiont |
Gene expression in normal tissue: ULK2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ULK2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04136 | Autophagy - other - Homo sapiens (human) |
| kegg | hsa04140 | Autophagy - animal - Homo sapiens (human) |
| kegg | hsa04150 | mTOR signaling pathway - Homo sapiens (human) |
| pid | mtor_4pathway | mTOR signaling pathway |
| wikipathways | WP1471 | Target Of Rapamycin (TOR) Signaling |
| wikipathways | WP2509 | Nanoparticle triggered autophagic cell death |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD425 | ERASTIN | 1 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD494 | Neopeltolide | 1 |
| iGMDRD427 | ABT737 | 2 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD152 | 179324-69-7 | 1 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD201 | SKI II | 3 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD466 | Chaetocin | 1 |
| iGMDRD679 | Bistramide A | 1 |
| iGMDRD260 | FQI-2 | 3 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD270 | Ciclosporin | 1 |
| iGMDRD52 | Rotenone | 3 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD171 | Pemetrexed | 1 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD887 | Compound 23 citrate | 1 |
| iGMDRD100 | Zebularine | 1 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD268 | Cerulenin | 1 |
| iGMDRD64 | Parbendazole | 1 |
| iGMDRD512 | nutlin 3 | 4 |
| iGMDRD307 | Manumycin A | 6 |
| iGMDRD48 | Dexamethasone | 3 |
| iGMDRD532 | Olaparib | 3 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD85 | Ursolic acid | 4 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD5 | Tyrphostin AG 1478 | 4 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD271 | Brefeldin A | 3 |
| iGMDRD213 | SMR000068650 | 3 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD662 | JQ-1 | 3 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD42 | Vorinostat | 1 |
| iGMDRD147 | Prima-1 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ULK2
CLASSFICATION
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