iGMDRD75

Canonical SMILES: CCC(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC3CC(CC(=O)O3)O)C

InChI: InChI=1S/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14-,15-,16-,18+,19+,20-,21-,23-/m0/s1

InChI Key: PCZOHLXUXFIOCF-BXMDZJJMSA-N

Standard NameCHEMBLPubchem CIDKEGG Drug IDDRUGBANK IDDrug StatusDrug targets (TTD)Drug Type
LovastatinCHEMBL503 53232D00359DB00227AloneDAP000551Small Molecule

Drug Class:

Anticholesteremic AgentsCardiovascular SystemCombined Inhibitors of CYP3A4 and P-glycoproteinCombined Inhibitors of CYP3A4 and P-glycoprotein (Moderate)CYP3A Substrates (Sensitive)Cytochrome P-450 CYP3A InhibitorsCytochrome P-450 CYP3A SubstratesCytochrome P-450 CYP3A4 InhibitorsCytochrome P-450 CYP3A4 Inhibitors (moderate)Cytochrome P-450 CYP3A4 SubstratesCytochrome P-450 CYP3A5 SubstratesCytochrome P-450 CYP3A7 SubstratesCytochrome P-450 Enzyme InducersCytochrome P-450 Enzyme InhibitorsEnzyme InhibitorsHydrocarbonsHydrocarbons, AromaticHydrocarbons, CyclicHydroxymethylglutaryl-CoA Reductase InhibitorsHypolipidemic AgentsLipid Modifying AgentsLipid Modifying Agents, PlainLipid Regulating AgentsNaphthalenesNoxaeOATP1B1/SLCO1B1 SubstratesP-glycoprotein/ABCB1 InhibitorsP-glycoprotein/ABCB1 SubstratesPolycyclic CompoundsPolycyclic Hydrocarbons, AromaticToxic ActionsUGT1A1 Substrates



Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot


Gene IDGene NameModel Num.
7514XPO11
10987COPS51
4771NF21
2625GATA31
5159PDGFRB1
5605MAP2K21
25937WWTR11
10018BCL2L111
57111RAB251
2194FASN1
2065ERBB31

Gene in drug-gene network: Network Plot

Models in Lovastatin

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