BCL2L11
Summary: The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
NameBCL2 like 11 OMIM IDMIM:603827 Ensembl IDEnsembl:ENSG00000153094 HGNC IDHGNC:HGNC:994 PHARMGKB IDPA25305 Map Location2q13 | |||||
GO terms in BCL2L11
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005739 | mitochondrion |
| CC | TAS | GO:0005741 | mitochondrial outer membrane |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0005868 | cytoplasmic dynein complex |
| CC | IEA | GO:0012505 | endomembrane system |
| CC | IEA | GO:0019898 | extrinsic component of membrane |
Gene expression in normal tissue: BCL2L11
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BCL2L11
Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109581 | Apoptosis |
| reactome | R-HSA-109606 | Intrinsic Pathway for Apoptosis |
| reactome | R-HSA-111446 | Activation of BIM and translocation to mitochondria |
| reactome | R-HSA-111453 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members |
| reactome | R-HSA-114452 | Activation of BH3-only proteins |
| reactome | R-HSA-162582 | Signal Transduction |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BCL2L11
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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