BCL2L11


Summary: The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
BCL2 like 11MIM:603827Ensembl:ENSG00000153094HGNC:HGNC:994PA253052q13

GO terms in BCL2L11


Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0005739mitochondrion
CCTASGO:0005741mitochondrial outer membrane
CCTASGO:0005829cytosol
CCIEAGO:0005868cytoplasmic dynein complex
CCIEAGO:0012505endomembrane system
CCIEAGO:0019898extrinsic component of membrane
CCIEAGO:0097136Bcl-2 family protein complex
BPIEAGO:0001701in utero embryonic development
BPIEAGO:0001782B cell homeostasis
BPIEAGO:0001783B cell apoptotic process
BPIEAGO:0001822kidney development
BPTASGO:0001844protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
BPIEAGO:0002262myeloid cell homeostasis
BPTASGO:0006915apoptotic process
BPIBAGO:0007127meiosis I
BPIEAGO:0007160cell-matrix adhesion
BPIEAGO:0007283spermatogenesis
BPIEAGO:0007420brain development
BPIEAGO:0008584male gonad development
BPIDAGO:0008630intrinsic apoptotic signaling pathway in response to DNA damage
BPIEAGO:0030879mammary gland development
BPIDAGO:0032464positive regulation of protein homooligomerization
BPIDAGO:0034976response to endoplasmic reticulum stress
BPIEAGO:0035148tube formation
BPIEAGO:0042475odontogenesis of dentin-containing tooth
BPTASGO:0042981regulation of apoptotic process
BPIEAGO:0043029T cell homeostasis
BPIBAGO:0043065positive regulation of apoptotic process
BPIMPGO:0043065positive regulation of apoptotic process
BPIEAGO:0043280positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
BPIEAGO:0043525positive regulation of neuron apoptotic process
BPIEAGO:0043583ear development
BPIEAGO:0045787positive regulation of cell cycle
BPIEAGO:0046620regulation of organ growth
BPIEAGO:0048066developmental pigmentation
BPIEAGO:0048070regulation of developmental pigmentation
BPIEAGO:0048536spleen development
BPIEAGO:0048538thymus development
BPIEAGO:0048563post-embryonic animal organ morphogenesis
BPIEAGO:0060139positive regulation of apoptotic process by virus
BPIEAGO:0060154cellular process regulating host cell cycle in response to virus
BPIEAGO:0070242thymocyte apoptotic process
BPTASGO:0071385cellular response to glucocorticoid stimulus
BPIGIGO:0090200positive regulation of release of cytochrome c from mitochondria
BPIMPGO:0090200positive regulation of release of cytochrome c from mitochondria
BPIEAGO:0097192extrinsic apoptotic signaling pathway in absence of ligand
BPTASGO:1902237positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
BPIEAGO:1902263apoptotic process involved in embryonic digit morphogenesis
BPTASGO:1903896positive regulation of IRE1-mediated unfolded protein response
BPIDAGO:2000271positive regulation of fibroblast apoptotic process
BPTASGO:2001244positive regulation of intrinsic apoptotic signaling pathway
MFIPIGO:0005515protein binding
MFIBAGO:0008017microtubule binding
MFIEAGO:0019901protein kinase binding
MFIEAGO:0046982protein heterodimerization activity
MFIEAGO:0070840dynein complex binding

Gene expression in normal tissue: BCL2L11

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in BCL2L11


DatabasePathway IDPathway Des.
reactomeR-HSA-109581Apoptosis
reactomeR-HSA-109606Intrinsic Pathway for Apoptosis
reactomeR-HSA-111446Activation of BIM and translocation to mitochondria
reactomeR-HSA-111453BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
reactomeR-HSA-114452Activation of BH3-only proteins
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-193648NRAGE signals death through JNK
reactomeR-HSA-193704p75 NTR receptor-mediated signalling
reactomeR-HSA-204998Cell death signalling via NRAGE, NRIF and NADE
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-5357801Programmed Cell Death
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-6802952Signaling by BRAF and RAF fusions
reactomeR-HSA-6802957Oncogenic MAPK signaling
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-73887Death Receptor Signalling
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8862803Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
reactomeR-HSA-8863678Neurodegenerative Diseases
reactomeR-HSA-8878159Transcriptional regulation by RUNX3
reactomeR-HSA-8952158RUNX3 regulates BCL2L11 (BIM) transcription
wikipathwaysWP1772Apoptosis Modulation and Signaling
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathwaysWP254Apoptosis
wikipathwaysWP3611Photodynamic therapy-induced AP-1 survival signaling.
wikipathwaysWP3613Photodynamic therapy-induced unfolded protein response
wikipathwaysWP3639Apoptotic Signaling Pathway
wikipathwaysWP3876BMP2-WNT4-FOXO1 Pathway in Human Primary Endometrial Stromal Cell Differentiation
wikipathwaysWP4107Transcriptional regulation by RUNX3
wikipathwaysWP4115Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer,s disease models
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP4216Chromosomal and microsatellite instability in colorectal cancer
wikipathwaysWP673ErbB Signaling Pathway
wikipathwaysWP710DNA Damage Response (only ATM dependent)
pidap1_pathwayAP-1 transcription factor network
pidfoxopathwayFoxO family signaling
pidp73pathwayp73 transcription factor network
pidp75ntrpathwayp75(NTR)-mediated signaling
netpathPathway_IL3IL3
kegghsa04068FoxO signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04210Apoptosis - Homo sapiens (human)
kegghsa04215Apoptosis - multiple species - Homo sapiens (human)
kegghsa04932Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)
kegghsa05210Colorectal cancer - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD210AC556493
iGMDRD409Saracatinib1
iGMDRD116CD4377
iGMDRD125BIRB-7961
iGMDRD614Dabrafenib1
iGMDRD160Cis-Platin1
iGMDRD462OSI-906 (Linsitinib)1
iGMDRD652UNC06381
iGMDRD75Lovastatin1
iGMDRD781Sirolimus5
iGMDRD446LY 21832402
iGMDRD201SKI II5
iGMDRD352PD-03259011
iGMDRD536PLX-47201
iGMDRD595PLX40321
iGMDRD154NSC237661
iGMDRD945ML2146
iGMDRD467Motesanib1
iGMDRD105Triptolide1
iGMDRD289Parthenolide1
iGMDRD318PAC-11
iGMDRD871BRD63685
iGMDRD473GDC-08791
iGMDRD329Merck605
iGMDRD140NSC196301
iGMDRD577BIX012942
iGMDRD780PP-303
iGMDRD561ABT-2631
iGMDRD894EGFR inhibitor1
iGMDRD82Quiflapon5
iGMDRD41Imatinib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BCL2L11

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