BCL2L11
Summary: The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| BCL2 like 11 | MIM:603827 | Ensembl:ENSG00000153094 | HGNC:HGNC:994 | PA25305 | 2q13 |
GO terms in BCL2L11
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005739 | mitochondrion |
| CC | TAS | GO:0005741 | mitochondrial outer membrane |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0005868 | cytoplasmic dynein complex |
| CC | IEA | GO:0012505 | endomembrane system |
| CC | IEA | GO:0019898 | extrinsic component of membrane |
| CC | IEA | GO:0097136 | Bcl-2 family protein complex |
| BP | IEA | GO:0001701 | in utero embryonic development |
| BP | IEA | GO:0001782 | B cell homeostasis |
| BP | IEA | GO:0001783 | B cell apoptotic process |
| BP | IEA | GO:0001822 | kidney development |
| BP | TAS | GO:0001844 | protein insertion into mitochondrial membrane involved in apoptotic signaling pathway |
| BP | IEA | GO:0002262 | myeloid cell homeostasis |
| BP | TAS | GO:0006915 | apoptotic process |
| BP | IBA | GO:0007127 | meiosis I |
| BP | IEA | GO:0007160 | cell-matrix adhesion |
| BP | IEA | GO:0007283 | spermatogenesis |
| BP | IEA | GO:0007420 | brain development |
| BP | IEA | GO:0008584 | male gonad development |
| BP | IDA | GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage |
| BP | IEA | GO:0030879 | mammary gland development |
| BP | IDA | GO:0032464 | positive regulation of protein homooligomerization |
| BP | IDA | GO:0034976 | response to endoplasmic reticulum stress |
| BP | IEA | GO:0035148 | tube formation |
| BP | IEA | GO:0042475 | odontogenesis of dentin-containing tooth |
| BP | TAS | GO:0042981 | regulation of apoptotic process |
| BP | IEA | GO:0043029 | T cell homeostasis |
| BP | IBA | GO:0043065 | positive regulation of apoptotic process |
| BP | IMP | GO:0043065 | positive regulation of apoptotic process |
| BP | IEA | GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | IEA | GO:0043525 | positive regulation of neuron apoptotic process |
| BP | IEA | GO:0043583 | ear development |
| BP | IEA | GO:0045787 | positive regulation of cell cycle |
| BP | IEA | GO:0046620 | regulation of organ growth |
| BP | IEA | GO:0048066 | developmental pigmentation |
| BP | IEA | GO:0048070 | regulation of developmental pigmentation |
| BP | IEA | GO:0048536 | spleen development |
| BP | IEA | GO:0048538 | thymus development |
| BP | IEA | GO:0048563 | post-embryonic animal organ morphogenesis |
| BP | IEA | GO:0060139 | positive regulation of apoptotic process by virus |
| BP | IEA | GO:0060154 | cellular process regulating host cell cycle in response to virus |
| BP | IEA | GO:0070242 | thymocyte apoptotic process |
| BP | TAS | GO:0071385 | cellular response to glucocorticoid stimulus |
| BP | IGI | GO:0090200 | positive regulation of release of cytochrome c from mitochondria |
| BP | IMP | GO:0090200 | positive regulation of release of cytochrome c from mitochondria |
| BP | IEA | GO:0097192 | extrinsic apoptotic signaling pathway in absence of ligand |
| BP | TAS | GO:1902237 | positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway |
| BP | IEA | GO:1902263 | apoptotic process involved in embryonic digit morphogenesis |
| BP | TAS | GO:1903896 | positive regulation of IRE1-mediated unfolded protein response |
| BP | IDA | GO:2000271 | positive regulation of fibroblast apoptotic process |
| BP | TAS | GO:2001244 | positive regulation of intrinsic apoptotic signaling pathway |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008017 | microtubule binding |
| MF | IEA | GO:0019901 | protein kinase binding |
| MF | IEA | GO:0046982 | protein heterodimerization activity |
| MF | IEA | GO:0070840 | dynein complex binding |
Gene expression in normal tissue: BCL2L11
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BCL2L11
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109581 | Apoptosis |
| reactome | R-HSA-109606 | Intrinsic Pathway for Apoptosis |
| reactome | R-HSA-111446 | Activation of BIM and translocation to mitochondria |
| reactome | R-HSA-111453 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members |
| reactome | R-HSA-114452 | Activation of BH3-only proteins |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-193648 | NRAGE signals death through JNK |
| reactome | R-HSA-193704 | p75 NTR receptor-mediated signalling |
| reactome | R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-5357801 | Programmed Cell Death |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-6802952 | Signaling by BRAF and RAF fusions |
| reactome | R-HSA-6802957 | Oncogenic MAPK signaling |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73887 | Death Receptor Signalling |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
| reactome | R-HSA-8863678 | Neurodegenerative Diseases |
| reactome | R-HSA-8878159 | Transcriptional regulation by RUNX3 |
| reactome | R-HSA-8952158 | RUNX3 regulates BCL2L11 (BIM) transcription |
| wikipathways | WP1772 | Apoptosis Modulation and Signaling |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP254 | Apoptosis |
| wikipathways | WP3611 | Photodynamic therapy-induced AP-1 survival signaling. |
| wikipathways | WP3613 | Photodynamic therapy-induced unfolded protein response |
| wikipathways | WP3639 | Apoptotic Signaling Pathway |
| wikipathways | WP3876 | BMP2-WNT4-FOXO1 Pathway in Human Primary Endometrial Stromal Cell Differentiation |
| wikipathways | WP4107 | Transcriptional regulation by RUNX3 |
| wikipathways | WP4115 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer,s disease models |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP4216 | Chromosomal and microsatellite instability in colorectal cancer |
| wikipathways | WP673 | ErbB Signaling Pathway |
| wikipathways | WP710 | DNA Damage Response (only ATM dependent) |
| pid | ap1_pathway | AP-1 transcription factor network |
| pid | foxopathway | FoxO family signaling |
| pid | p73pathway | p73 transcription factor network |
| pid | p75ntrpathway | p75(NTR)-mediated signaling |
| netpath | Pathway_IL3 | IL3 |
| kegg | hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| kegg | hsa04215 | Apoptosis - multiple species - Homo sapiens (human) |
| kegg | hsa04932 | Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| kegg | hsa05210 | Colorectal cancer - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD210 | AC55649 | 3 |
| iGMDRD409 | Saracatinib | 1 |
| iGMDRD116 | CD437 | 7 |
| iGMDRD125 | BIRB-796 | 1 |
| iGMDRD614 | Dabrafenib | 1 |
| iGMDRD160 | Cis-Platin | 1 |
| iGMDRD462 | OSI-906 (Linsitinib) | 1 |
| iGMDRD652 | UNC0638 | 1 |
| iGMDRD75 | Lovastatin | 1 |
| iGMDRD781 | Sirolimus | 5 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD201 | SKI II | 5 |
| iGMDRD352 | PD-0325901 | 1 |
| iGMDRD536 | PLX-4720 | 1 |
| iGMDRD595 | PLX4032 | 1 |
| iGMDRD154 | NSC23766 | 1 |
| iGMDRD945 | ML214 | 6 |
| iGMDRD467 | Motesanib | 1 |
| iGMDRD105 | Triptolide | 1 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD871 | BRD6368 | 5 |
| iGMDRD473 | GDC-0879 | 1 |
| iGMDRD329 | Merck60 | 5 |
| iGMDRD140 | NSC19630 | 1 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD561 | ABT-263 | 1 |
| iGMDRD894 | EGFR inhibitor | 1 |
| iGMDRD82 | Quiflapon | 5 |
| iGMDRD41 | Imatinib | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BCL2L11
CLASSFICATION
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