COPS5


Summary: The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
COP9 signalosome subunit 5MIM:604850Ensembl:ENSG00000121022HGNC:HGNC:2240PA267578q13.1

GO terms in COPS5


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0003713transcription coactivator activity
MFTASGO:0003743translation initiation factor activity
MFIEAGO:0004222metalloendopeptidase activity
MFIDAGO:0004843thiol-dependent ubiquitin-specific protease activity
MFIPIGO:0005515protein binding
MFIBAGO:0008237metallopeptidase activity
MFIMPGO:0008237metallopeptidase activity
MFIBAGO:0019784NEDD8-specific protease activity
MFTASGO:0019784NEDD8-specific protease activity
MFIEAGO:0019899enzyme binding
MFIEAGO:0035718macrophage migration inhibitory factor binding
MFIEAGO:0046872metal ion binding
BPIBAGO:0000338protein deneddylation
BPIDAGO:0000338protein deneddylation
BPIMPGO:0000338protein deneddylation
BPTASGO:0000715nucleotide-excision repair, DNA damage recognition
BPTASGO:0006283transcription-coupled nucleotide-excision repair
BPTASGO:0006366transcription by RNA polymerase II
BPTASGO:0006412translation
BPIEAGO:0006413translational initiation
BPIDAGO:0016579protein deubiquitination
BPIMPGO:0043066negative regulation of apoptotic process
BPTASGO:0043687post-translational protein modification
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0046328regulation of JNK cascade
BPIDAGO:0051091positive regulation of DNA-binding transcription factor activity
BPIEAGO:0051726regulation of cell cycle
BPIMPGO:1903894regulation of IRE1-mediated unfolded protein response
BPIDAGO:1990182exosomal secretion
CCIDAGO:0000785chromatin
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIBAGO:0005737cytoplasm
CCIDAGO:0005737cytoplasm
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCTASGO:0005852eukaryotic translation initiation factor 3 complex
CCIDAGO:0008021synaptic vesicle
CCIBAGO:0008180COP9 signalosome
CCIDAGO:0008180COP9 signalosome
CCIEAGO:0030054cell junction
CCIEAGO:0048471perinuclear region of cytoplasm

Gene expression in normal tissue: COPS5

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in COPS5


DatabasePathway IDPathway Des.
biocartaeponfkbpathwayerythropoietin mediated neuroprotection through nf-kb
biocartahifpathwayhypoxia-inducible factor in the cardivascular system
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-5696394DNA Damage Recognition in GG-NER
reactomeR-HSA-5696398Nucleotide Excision Repair
reactomeR-HSA-5696399Global Genome Nucleotide Excision Repair (GG-NER)
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-6781823Formation of TC-NER Pre-Incision Complex
reactomeR-HSA-6781827Transcription-Coupled Nucleotide Excision Repair (TC-NER)
reactomeR-HSA-73894DNA Repair
reactomeR-HSA-8856825Cargo recognition for clathrin-mediated endocytosis
reactomeR-HSA-8856828Clathrin-mediated endocytosis
reactomeR-HSA-8951664Neddylation
wikipathwaysWP366TGF-beta Signaling Pathway
netpathPathway_TGF_beta_ReceptorTGF_beta_Receptor
pidap1_pathwayAP-1 transcription factor network
pidhif1_tfpathwayHIF-1-alpha transcription factor network
pidhif1apathwayHypoxic and oxygen homeostasis regulation of HIF-1-alpha

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD446LY 21832404
iGMDRD152179324-69-73
iGMDRD61Kinetin riboside4
iGMDRD394BX-7953
iGMDRD297Austocystin D4
iGMDRD126Tipifarnib1
iGMDRD76Simvastatin1
iGMDRD387CHIR-990211
iGMDRD599Salermide3
iGMDRD779PRL-3 Inhibitor I1
iGMDRD144NSC953976
iGMDRD1Nicotin-Amide1
iGMDRD75Lovastatin1
iGMDRD489GSK-4613641
iGMDRD188Piperlongumine9
iGMDRD100Zebularine6
iGMDRD451Serdemetan3
iGMDRD86Betulinic acid1
iGMDRD138PX 123
iGMDRD613CHEMBL2581481
iGMDRD255SB2250024
iGMDRD574Ruxolitinib1
iGMDRD187BRD98763
iGMDRD870BRD636103
iGMDRD85Ursolic acid3
iGMDRD170Fluvastatin1
iGMDRD676Birinapant1
iGMDRD211(1S,3R)-RSL33
iGMDRD116CD4373
iGMDRD532Olaparib1
iGMDRD414MST-3127
iGMDRD286Nsc 6328396
iGMDRD662JQ-13
iGMDRD263AACOCF31
iGMDRD322FK 8663
iGMDRD946ML3201
iGMDRD556Quizartinib1
iGMDRD251ML1623
iGMDRD121GMX17781
iGMDRD103SN-386
iGMDRD787PF 1841
iGMDRD434BMS-5369241
iGMDRD289Parthenolide3
iGMDRD504Obatoclax1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in COPS5

​​​​