COPS5
Summary: The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| COP9 signalosome subunit 5 | MIM:604850 | Ensembl:ENSG00000121022 | HGNC:HGNC:2240 | PA26757 | 8q13.1 |
GO terms in COPS5
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0003713 | transcription coactivator activity |
| MF | TAS | GO:0003743 | translation initiation factor activity |
| MF | IEA | GO:0004222 | metalloendopeptidase activity |
| MF | IDA | GO:0004843 | thiol-dependent ubiquitin-specific protease activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008237 | metallopeptidase activity |
| MF | IMP | GO:0008237 | metallopeptidase activity |
| MF | IBA | GO:0019784 | NEDD8-specific protease activity |
| MF | TAS | GO:0019784 | NEDD8-specific protease activity |
| MF | IEA | GO:0019899 | enzyme binding |
| MF | IEA | GO:0035718 | macrophage migration inhibitory factor binding |
| MF | IEA | GO:0046872 | metal ion binding |
| BP | IBA | GO:0000338 | protein deneddylation |
| BP | IDA | GO:0000338 | protein deneddylation |
| BP | IMP | GO:0000338 | protein deneddylation |
| BP | TAS | GO:0000715 | nucleotide-excision repair, DNA damage recognition |
| BP | TAS | GO:0006283 | transcription-coupled nucleotide-excision repair |
| BP | TAS | GO:0006366 | transcription by RNA polymerase II |
| BP | TAS | GO:0006412 | translation |
| BP | IEA | GO:0006413 | translational initiation |
| BP | IDA | GO:0016579 | protein deubiquitination |
| BP | IMP | GO:0043066 | negative regulation of apoptotic process |
| BP | TAS | GO:0043687 | post-translational protein modification |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0046328 | regulation of JNK cascade |
| BP | IDA | GO:0051091 | positive regulation of DNA-binding transcription factor activity |
| BP | IEA | GO:0051726 | regulation of cell cycle |
| BP | IMP | GO:1903894 | regulation of IRE1-mediated unfolded protein response |
| BP | IDA | GO:1990182 | exosomal secretion |
| CC | IDA | GO:0000785 | chromatin |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | TAS | GO:0005852 | eukaryotic translation initiation factor 3 complex |
| CC | IDA | GO:0008021 | synaptic vesicle |
| CC | IBA | GO:0008180 | COP9 signalosome |
| CC | IDA | GO:0008180 | COP9 signalosome |
| CC | IEA | GO:0030054 | cell junction |
| CC | IEA | GO:0048471 | perinuclear region of cytoplasm |
Gene expression in normal tissue: COPS5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in COPS5
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | eponfkbpathway | erythropoietin mediated neuroprotection through nf-kb |
| biocarta | hifpathway | hypoxia-inducible factor in the cardivascular system |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-5696394 | DNA Damage Recognition in GG-NER |
| reactome | R-HSA-5696398 | Nucleotide Excision Repair |
| reactome | R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex |
| reactome | R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| reactome | R-HSA-73894 | DNA Repair |
| reactome | R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis |
| reactome | R-HSA-8856828 | Clathrin-mediated endocytosis |
| reactome | R-HSA-8951664 | Neddylation |
| wikipathways | WP366 | TGF-beta Signaling Pathway |
| netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
| pid | ap1_pathway | AP-1 transcription factor network |
| pid | hif1_tfpathway | HIF-1-alpha transcription factor network |
| pid | hif1apathway | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD152 | 179324-69-7 | 3 |
| iGMDRD61 | Kinetin riboside | 4 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD297 | Austocystin D | 4 |
| iGMDRD126 | Tipifarnib | 1 |
| iGMDRD76 | Simvastatin | 1 |
| iGMDRD387 | CHIR-99021 | 1 |
| iGMDRD599 | Salermide | 3 |
| iGMDRD779 | PRL-3 Inhibitor I | 1 |
| iGMDRD144 | NSC95397 | 6 |
| iGMDRD1 | Nicotin-Amide | 1 |
| iGMDRD75 | Lovastatin | 1 |
| iGMDRD489 | GSK-461364 | 1 |
| iGMDRD188 | Piperlongumine | 9 |
| iGMDRD100 | Zebularine | 6 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD86 | Betulinic acid | 1 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD613 | CHEMBL258148 | 1 |
| iGMDRD255 | SB225002 | 4 |
| iGMDRD574 | Ruxolitinib | 1 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD170 | Fluvastatin | 1 |
| iGMDRD676 | Birinapant | 1 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD532 | Olaparib | 1 |
| iGMDRD414 | MST-312 | 7 |
| iGMDRD286 | Nsc 632839 | 6 |
| iGMDRD662 | JQ-1 | 3 |
| iGMDRD263 | AACOCF3 | 1 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD946 | ML320 | 1 |
| iGMDRD556 | Quizartinib | 1 |
| iGMDRD251 | ML162 | 3 |
| iGMDRD121 | GMX1778 | 1 |
| iGMDRD103 | SN-38 | 6 |
| iGMDRD787 | PF 184 | 1 |
| iGMDRD434 | BMS-536924 | 1 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD504 | Obatoclax | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in COPS5
CLASSFICATION
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